Homogeneous Oxidation of EE2 by Ozone: Influencing Factors, Degradation Pathway, and Toxicity Assessment DOI

Xiaowan Dong,

Shixin Yu,

Wen Yang

et al.

Published: Jan. 1, 2023

17α-Ethinylestradiol(EE2) is a common hormone drug that plays an essential role in endocrine and reproductive health. However, estrogens are degraded only to limited extent by humans livestock themselves, most of them excreted undegraded or partially form urine into water bodies, posing serious ecological risk. Among the known degradation methods wastewater treatment plants, ozone-induced advanced oxidation shows great potential. in-depth study mechanism difficult due limitations testing methods. In this study, influencing factors, including ozone dose, initial concentration, pH were investigated. The pathways EE2 analyzed combing with quantum chemical calculations HPLC-Q-TOF-MS. toxicity its intermediates evaluated Toxicity Estimation Software Tool. results showed reactions such as oxidative hydroxylation benzene ring opening aliphatic mainly occurred during estrogens. products experimental reflect active site, e.g., product P1 reflects C5 site easy reaction, which consistent previous theoretical predictions, suggesting studies can provide complementary information on oxidation. obtained from partial improved compared EE2, mutagenicity was elevated greatly. single ozonation significantly diminished bioaccumulation factor developmental intermediates. This work may basis for practical application environmental

Language: Английский

Homogeneous oxidation of EE2 by ozone: Influencing factors, degradation pathway, and toxicity assessment DOI

Xiaowan Dong,

Shixin Yu,

Wen Yang

et al.

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(2), P. 112360 - 112360

Published: March 2, 2024

Language: Английский

Citations

7
Dietary exposure to 17α‐ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio) DOI Open Access
Aneta Hollerová,

Nikola Peskova,

Zuzana Weiserova

et al.

Journal of Fish Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Abstract Pollution of the aquatic ecosystem by hormone‐active substances is a frequently discussed topic these days. Such can pass through sewage treatment plant system and affect life. This study tested effect 17α‐ethinylestradiol (EE2) on individual zebrafish ( Danio rerio ) at an environmentally relevant concentration in fish food (10 μg/kg) 100 times higher (1000 μg/kg). experiment revealed significant changes expression reproductive genes, increase vitellogenin levels histopathological lesions testes after EE2 exposure. Additionally, lipid peroxidation antioxidant enzyme activities were observed both concentrations, along with morphological increased mortality concentration. Even poses danger to organisms as it D. 's health parameters, indicating toxicity molecular, cell, tissue, organism levels.

Language: Английский

Citations

0
Anthropogenic stressors and the marine environment: From sources and impacts to solutions and mitigation DOI Creative Commons

Angelina L Hajji,

Kelsey Lucas

Marine Pollution Bulletin, Journal Year: 2024, Volume and Issue: 205, P. 116557 - 116557

Published: June 14, 2024

Human-released contaminants are often poorly understood wholistically in marine ecosystems. This review examines the sources, pathways, impacts on animals, and mitigation strategies of five pollutants (plastics, per- polyfluoroalkyl substances, bisphenol compounds, ethynylestradiol, petroleum hydrocarbons). Both abiotic biotic mechanisms contribute to all contaminants' movement. These cause short- long-term effects many biological processes genetically, molecularly, neurologically, physiologically, reproductively, developmentally. We explore extension adverse outcome pathways ecosystem by considering known inter-generational trophic relations resulting large-scale direct indirect impacts. In doing so, we develop an understanding their roles as environmental stressors environments for targeted future work. Ecosystems interconnected so international collaboration, standards, measures preceding mass production, citizen involvement required protect conserve life.

Language: Английский

Citations

3
The expression of liver–gonadal axis genes reveals the long–term effects of exogenous estradiol on gonad development and liver function in GIFT tilapia DOI
Ye Yuan, Zexun Zhou, Sheng Chen

et al.

Reproduction and Breeding, Journal Year: 2025, Volume and Issue: 5(2), P. 11 - 20

Published: March 8, 2025

Language: Английский

Citations

0
A review of cumulative toxic effects of environmental endocrine disruptors on the zebrafish immune system: Characterization methods, toxic effects and mechanisms DOI

Zixu Li,

M. Li,

Dan Li

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 246, P. 118010 - 118010

Published: Dec. 27, 2023

Language: Английский

Citations

6
Sex-specific divergent responses of marine medaka (Oryzias melastigma) towards long-term benzo[a]pyrene exposure revealed stronger resilience and recoverability in female fish DOI

Rabia Zeb,

Xiaohan Yin, Fangyi Chen

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 364, P. 143077 - 143077

Published: Aug. 10, 2024

Language: Английский

Citations

0
Ten-month comprehensive assessment of steroid hormones in the tributaries of Baiyun District, Guangzhou City, China: Spatiotemporal dynamics, source attribution, and environmental implications DOI

Manxin Xu,

Shudong Lu,

Weisong Chen

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 958, P. 177908 - 177908

Published: Dec. 6, 2024

Language: Английский

Citations

0
Homogeneous Oxidation of EE2 by Ozone: Influencing Factors, Degradation Pathway, and Toxicity Assessment DOI

Xiaowan Dong,

Shixin Yu,

Wen Yang

et al.

Published: Jan. 1, 2023

17α-Ethinylestradiol(EE2) is a common hormone drug that plays an essential role in endocrine and reproductive health. However, estrogens are degraded only to limited extent by humans livestock themselves, most of them excreted undegraded or partially form urine into water bodies, posing serious ecological risk. Among the known degradation methods wastewater treatment plants, ozone-induced advanced oxidation shows great potential. in-depth study mechanism difficult due limitations testing methods. In this study, influencing factors, including ozone dose, initial concentration, pH were investigated. The pathways EE2 analyzed combing with quantum chemical calculations HPLC-Q-TOF-MS. toxicity its intermediates evaluated Toxicity Estimation Software Tool. results showed reactions such as oxidative hydroxylation benzene ring opening aliphatic mainly occurred during estrogens. products experimental reflect active site, e.g., product P1 reflects C5 site easy reaction, which consistent previous theoretical predictions, suggesting studies can provide complementary information on oxidation. obtained from partial improved compared EE2, mutagenicity was elevated greatly. single ozonation significantly diminished bioaccumulation factor developmental intermediates. This work may basis for practical application environmental

Language: Английский

Citations

0