Toxics,
Journal Year:
2025,
Volume and Issue:
13(3), P. 165 - 165
Published: Feb. 26, 2025
Microplastic
(MP)
pollution
is
a
major
environmental
problem,
but
comparative
study
of
the
toxicological
effects
different
MPs
remains
lacking.
To
explore
three
microplastics,
namely,
polypropylene
(PP),
polystyrene
(PS)
and
polyethylene
(PE),
Zhenhai
brown
frog
(Rana
zhenhaiensis)
tadpoles
were
used
as
model
animal.
The
results
showed
that
exposure
to
PE
PS
significantly
reduced
metamorphosis
rate
tadpoles.
Compared
with
control
group,
body
weight
in
all
MP
treatments
was
compared
group.
In
addition,
length
hind
limb
number
pigment
cells
increased
intercellular
spaces
expanded
liver
tissues
receiving
treatments.
composition
function
intestinal
microbiota
PP
treatment
groups
similar,
whereas
between
control,
they
differed.
Liver
transcriptome
sequencing
revealed
significant
alterations
key
genes
associated
oxidative
stress,
energy
metabolism,
immune
response,
apoptosis
signaling
pathways
treatment.
summary,
may
have
harmed
varying
degrees
by
interfering
related
pathways.
negative
greater
than
those
PP.
Environment International,
Journal Year:
2025,
Volume and Issue:
197, P. 109358 - 109358
Published: March 1, 2025
This
study
examined
the
effects
of
hot
high-fat
simulants
on
physicochemical
properties
microplastics
(MPs)
from
polypropylene
(PP)-,
low-density
polyethylene
(LDPE)-,
and
polylactic
acid
(PLA)-based
single-use
food
container
(SUFC)
leachates
those
aging
their
immunomodulatory
effectors.
Scenario
studies
have
demonstrated
that
MPs
were
released
these
three
types
SUFCs.
LDPE-
PLA-based
SUFCs
also
cellulose.
Among
SUFCs,
only
PP
particles
exhibited
a
new
absorption
peak
at
1725
cm-1,
which
phenomenon
may
be
attributed
to
presence
unstable
tertiary
carbon
atoms.
Subsequently,
we
investigated
removing
additive
both
thermal-aged
with
polystyrene
(PS)
carboxyl-modified
PS
(PS-COOH)
polymer
backbones
as
reference
materials.
The
findings
indicated
PS-COOH
induced
comparable
innate
immune
responses,
exhibiting
similar
size
SUFC
percolates.
Consequently,
selected
original
MPs,
respectively,
evaluate
immunity.
results
revealed
thata
protein
corona
formed
particle
types,
more
adsorption
observed
particles.
complex
enhanced
phagocytosis
RAW264.7
macrophages
increased
expression
pro-inflammatory
genes
NOS2
TNF-α
through
an
actin
polymerization
cross-linking
mechanism.
In
this
study,
how
affect
responses
using
model
system,
emphasizing
importance
comprehensive
safety
evaluations
MPs.
