The Invertebrate Immunocyte: A Complex and Versatile Model for Immunological, Developmental, and Environmental Research DOI Creative Commons

Sandro Sacchi,

Davide Malagoli, Nicola Franchi

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2106 - 2106

Published: Dec. 19, 2024

The knowledge of comparative and developmental immunobiology has grown over the years been strengthened by contributions multi-omics research. High-performance microscopy, flow cytometry, scRNA sequencing, increased capacity to handle complex data introduced machine learning have allowed uncovering aspects great complexity diversity in invertebrate immunocytes, i.e., immune-related circulating cells, which until a few ago could only be described terms morphology basic cellular functions, such as phagocytosis or enzymatic activity. Today, immunocytes are recognized sophisticated biological entities, involved host defense, stress response, wound healing, organ regeneration, but also numerous functional organismal life not directly related embryonic development, metamorphosis, tissue homeostasis. multiple functions do always fit description organisms simplified systems compared those represented vertebrates. However, precisely increasing revealed makes increasingly suitable models for addressing biologically significant specific questions, while continuing present undeniable advantages associated with their ethical economic sustainability.

Language: Английский

A Multilevel Risk Assessment Framework for Nanoplastics in Aquatic Ecosystems DOI Open Access
Cátia Venâncio, Miguel Oliveira

Water, Journal Year: 2025, Volume and Issue: 17(2), P. 180 - 180

Published: Jan. 10, 2025

To date, the assessment of risks related to nanoplastics (NPLs) has been incipient. Attempts establish safety levels support decisions regarding restrictions on use or reuse materials derived from petrochemicals are critical, but complexity datasets makes it difficult communicate potential NPLs-related environmental risks. Therefore, seems essential reduce relevant data a factor/number that easier clarify whether there is risk and, above all, easily report information legislators so prohibition, reductions, and/or readjustments monitoring programs can be implemented accordingly. Accordingly, this study aimed propose an improved and tiered for NPLs following NORMAN network, which may outlined as follows: (i) conducting screenings assess level through deterministic methodologies (involving collection effective concentrations or, in their absence, no-effect lowest-effect concentrations, also known NOEC LOEC, respectively); (ii) comparing exceedance values obtained previously relation predicted non-environmental (PNECs); (iii) ranking different NPL types based prioritization indeces facilitate future decision-making. Of total six polymers available, was only possible deliver indices three (two freshwater one saltwater) due lack PNEC (PECs). The majority research topic focused PS. PS classified high-priority polymer, since its estimated index ≥65 (the base value 1). Furthermore, freshwater, PE indicated priority polymer (with exceeding 1000). It should noted other widely used (such PMMA PVC), insufficient data. therefore clear current management control measures products containing must reconsidered NPLs’ impacts.

Language: Английский

Citations

0
Unraveling the Impact of Micro- and Nano-sized Polymethyl methacrylate on Gut Microbiota and Liver Lipid Metabolism: Insights from Oral Exposure Studies DOI

Peng Chen Zheng,

Xin Pan, Yi Zhou

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126157 - 126157

Published: March 1, 2025

Language: Английский

Citations

0
The Role of Life Stages in the Sensitivity of Hediste diversicolor to Nanoplastics: A Case Study with Poly(Methyl)Methacrylate (PMMA) DOI Creative Commons

Beatriz Neves,

Miguel Oliveira, Carolina Frazão

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(5), P. 352 - 352

Published: May 10, 2024

The presence of plastic particles in oceans has been recognized as a major environmental concern. decrease particle size increases their ability to directly interact with biota, the nanometer range (nanoplastics-NPs) displaying higher penetrate biological membranes, which size. This study aimed evaluate role life stages effects poly(methyl)methacrylate (PMMA) NPs on polychaete Hediste diversicolor, key species marine food web and nutrient cycle. Thus, behavioral (burrowing activity clean spiked sediment) biochemical endpoints (neurotransmission, energy reserves, antioxidant defenses, oxidative damage) were assessed juvenile adult organisms after 10 days exposure sediment (between 0.5 128 mg PMMA NPs/Kg sediment). Overall, results show that H. diversicolor is sensitive NPs. In juveniles, exposed took longer burrow sediment, significant differences from controls being observed at all tested concentrations when test was performed whereas NP-spiked only found 8, 32, sediment. Adults displayed lower sensitivity, found, for both types, terms Acetylcholinesterase, used marker neurotransmission, juveniles adults opposite trends, increased (suggesting apoptosis), adults, overall decreased found. Energy-related parameters revealed generally similar pattern (increase organisms) sensitivity (significant even concentrations). also demonstrated increase defenses (higher juveniles), damage protein carbonylation (all conditions) juveniles. data reveal potential affect behavior induce toxic greater

Language: Английский

Citations

2
Potential advantage of invasive estuarine worms over native species under exposure to relevant concentrations of graphene oxide: behavioral and biochemical insights DOI Creative Commons

Maria João Figueiredo,

Cátia Venâncio, Paulo Cardoso

et al.

Marine Environmental Research, Journal Year: 2024, Volume and Issue: 202, P. 106821 - 106821

Published: Oct. 30, 2024

Language: Английский

Citations

1
Trophic transfer effects of PS nanoplastics and field-derived nanoplastics in the freshwater clam Corbicula fluminea DOI Creative Commons
Oïhana Latchere, Isabelle Métais, Hanane Perrein-Ettajani

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 277, P. 107160 - 107160

Published: Nov. 10, 2024

Language: Английский

Citations

0
Oxidative Stress in Mussel Mytilus trossulus Induced by Different-Sized Plastics DOI Creative Commons
Nadezda Vladimirovna Dovzhenko, Valentina Vladimirovna Slobodskova, Andrey Alexandrovich Mazur

et al.

Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(4), P. 1826 - 1835

Published: Nov. 22, 2024

Polyethylene and polystyrene are massively used around the world in various applications most abundant plastic waste. Once marine environment, under influence of physical chemical factors, products degrade, changing from size category macroplastics to microplastics. In order study effect on organisms, we modeled conditions environmental pollution with different-sized plastic—polystyrene microparticles 0.9 µm macro-sized polyethylene fragments 10 cm—and compared their biochemical parameters tissues bivalve mollusk Mytilus trossulus. Using biomarkers, it was found that regardless type polymer, macrofragments induced development oxidative stress mussels. A significant decrease level lysosomal stability mussel hemocytes observed. Increases DNA damage concentration malonic dialdehyde cells gills digestive gland were also shown. The total antiradical activity varied had a tissue-specific character. It shown both ingested particles leachable compounds toxic for

Language: Английский

Citations

0
The Invertebrate Immunocyte: A Complex and Versatile Model for Immunological, Developmental, and Environmental Research DOI Creative Commons

Sandro Sacchi,

Davide Malagoli, Nicola Franchi

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2106 - 2106

Published: Dec. 19, 2024

The knowledge of comparative and developmental immunobiology has grown over the years been strengthened by contributions multi-omics research. High-performance microscopy, flow cytometry, scRNA sequencing, increased capacity to handle complex data introduced machine learning have allowed uncovering aspects great complexity diversity in invertebrate immunocytes, i.e., immune-related circulating cells, which until a few ago could only be described terms morphology basic cellular functions, such as phagocytosis or enzymatic activity. Today, immunocytes are recognized sophisticated biological entities, involved host defense, stress response, wound healing, organ regeneration, but also numerous functional organismal life not directly related embryonic development, metamorphosis, tissue homeostasis. multiple functions do always fit description organisms simplified systems compared those represented vertebrates. However, precisely increasing revealed makes increasingly suitable models for addressing biologically significant specific questions, while continuing present undeniable advantages associated with their ethical economic sustainability.

Language: Английский

Citations

0