Comparative impact of pristine and aged microplastics with triclosan on lipid metabolism in larval zebrafish: Unveiling the regulatory role of miR-217
Xingcheng Liu,
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Qian Pu,
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Ying Cheng
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et al.
The Science of The Total Environment,
Journal Year:
2024,
Volume and Issue:
929, P. 172580 - 172580
Published: April 22, 2024
Language: Английский
Co-Existing Nanoplastics Further Exacerbates the Effects of Triclosan on the Physiological Functions of Human Serum Albumin
Life,
Journal Year:
2025,
Volume and Issue:
15(1), P. 112 - 112
Published: Jan. 16, 2025
The
potential
health
risks
posed
by
the
coexistence
of
nanoplastics
(NPs)
and
triclosan
(TCS)
have
garnered
significant
attention.
However,
effects
underlying
mechanisms
NPs
TCS
on
key
functional
proteins
at
molecular
level
remain
poorly
understood.
This
study
reports
effect
polystyrene
(PSNPs)
binding
to
human
serum
albumin
(HSA)
using
multispectral
methods
simulation
systems.
experimental
results
show
that
significantly
inhibits
HSA
esterase
activity,
with
exacerbating
inhibition
in
presence
PSNPs,
which
is
attributed
alteration
conformation
microenvironment
amino
acid
residues
induced
PSNPs.
Molecular
docking
site
marker
competitive
studies
indicate
predominantly
binds
I
subdomain
Sudlow
II
PSNPs
does
not
affect
sites.
Spectra
analyses
quenching
mechanism
between
belongs
static
type
change
fluorescence
type.
conformational
alterations
are
further
enhanced
indicating
enhance
making
more
accessible
provides
valuable
information
about
toxicity
case
co-exposure.
Language: Английский
6-PPD triggered lipid metabolism disorder and inflammatory response in larval zebrafish (Danio rerio) by regulating PPARγ/NF-κB pathway
Qiuhui Qian,
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Ji Wu,
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Cuizhen Wang
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et al.
Environmental Pollution,
Journal Year:
2025,
Volume and Issue:
unknown, P. 125785 - 125785
Published: Feb. 1, 2025
Language: Английский
Triclosan affects steroidogenesis in mouse primary astrocytes in vitro with engagement of Sirtuin 1 and 3
The Journal of Steroid Biochemistry and Molecular Biology,
Journal Year:
2024,
Volume and Issue:
243, P. 106586 - 106586
Published: July 14, 2024
Triclosan
(TCS)
is
a
widely
used
antimicrobial,
antifungal,
and
antiviral
agent.
To
date,
it
has
been
reported
that
TCS
can
enter
the
human
body
disrupt
hormonal
homeostasis.
Therefore,
aim
of
our
paper
was
to
evaluate
impact
on
astrocytes,
i.e.
crucial
population
cells
responsible
for
steroid
hormone
production.
Our
data
showed
that,
in
mouse
primary
astrocyte
cultures,
act
as
an
endocrine
disrupting
chemical
through
destabilization
production
or
secretion
progesterone
(P
Language: Английский
Lipid Droplets in Aquatic Animals: Diversity, Biogenesis, and Functional Implications
Reviews in Aquaculture,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Nov. 29, 2024
ABSTRACT
Amid
the
aquaculture
boom,
chemical
contaminants,
diseases,
and
improper
nutrition
persist
as
threats
to
sustainability
of
aquaculture.
The
accumulation
lipid
droplets
in
different
tissues
has
emerged
a
hallmark
aquatic
animals
exposed
these
stressors.
While
abundant
knowledge
is
available
on
mammals,
relatively
little
known
animals.
Recently,
interest
grown
parallel
with
recognition
that
they
are
actively
engaged
regulation
stress
responses,
metabolic
modulation,
infections,
immune
response
This
review
first
outlines
diversity
protein
various
discusses
function
maintaining
cellular
homeostasis
by
contacting
other
organelles.
Subsequently,
mechanisms
droplet
biogenesis
contaminants
summarized.
Additionally,
we
describe
complex
roles
host‐pathogen
dynamic
link
between
excessive
unwanted
diseases
several
Finally,
potential
application
presented.
A
better
understanding
dynamics
functions
will
facilitate
development
droplets‐based
therapeutic
strategies,
thereby
improving
Language: Английский