Curcumin as a protective agent against chromium and ammonia toxicity using molecular and biochemical approaches in fish DOI Creative Commons
Abeda Mulla,

Supriya Tukaram Thorat,

Kalpana Chandramore

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 8, 2025

In aquatic ecosystems, metal and ammonia pollution pose major concern as they contaminate the environment induces toxicity in fish. The present study addresses induced by chromium (Cr) (NH3) fish investigates potential of dietary curcumin mitigating effects concurrent exposure to theses stressors Pangasianodon hypophthalmus. Three isonitrogenous isocaloric diets were formulated: a control diet (0% curcumin) two curcumin-supplemented containing 0.1% 0.2% curcumin. Four experimental groups designed completely randomized design: (1) control, (2) Cr NH3 fed with diet, (3) exposure, (4) exposure. Fish followed under stress, exhibited significantly reduced cortisol levels compared + groups. Similarly, expression HSP70 iNOS genes liver tissue was downregulated curcumin-fed other Concurrent led considerable increase oxidative stress enzyme kidney tissues, including glutathione S-transferase (GST), catalase (CAT), superoxide dismutase (SOD). However, supplementation activities. markedly acetylcholinesterase (AChE) activity, but restored AChE activity. stress-related such cytochrome P450 (CYP450), caspase-3a (Cas3a), tumor necrosis factor-alpha (TNF-α) noticeably groups, reducing impact stress. Furthermore, total immunoglobulin (Ig) growth-related gene expression, growth hormone (GH) receptor 1 (GHR1), upregulated group all Additionally, myostatin (MYST) group. Activities cellular metabolic digestive enzymes improved supplementation, adverse Moreover, bioaccumulation different tissues This highlights through regulation, thereby improving physiological productive performance

Language: Английский

Curcumin as a protective agent against chromium and ammonia toxicity using molecular and biochemical approaches in fish DOI Creative Commons
Abeda Mulla,

Supriya Tukaram Thorat,

Kalpana Chandramore

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 8, 2025

In aquatic ecosystems, metal and ammonia pollution pose major concern as they contaminate the environment induces toxicity in fish. The present study addresses induced by chromium (Cr) (NH3) fish investigates potential of dietary curcumin mitigating effects concurrent exposure to theses stressors Pangasianodon hypophthalmus. Three isonitrogenous isocaloric diets were formulated: a control diet (0% curcumin) two curcumin-supplemented containing 0.1% 0.2% curcumin. Four experimental groups designed completely randomized design: (1) control, (2) Cr NH3 fed with diet, (3) exposure, (4) exposure. Fish followed under stress, exhibited significantly reduced cortisol levels compared + groups. Similarly, expression HSP70 iNOS genes liver tissue was downregulated curcumin-fed other Concurrent led considerable increase oxidative stress enzyme kidney tissues, including glutathione S-transferase (GST), catalase (CAT), superoxide dismutase (SOD). However, supplementation activities. markedly acetylcholinesterase (AChE) activity, but restored AChE activity. stress-related such cytochrome P450 (CYP450), caspase-3a (Cas3a), tumor necrosis factor-alpha (TNF-α) noticeably groups, reducing impact stress. Furthermore, total immunoglobulin (Ig) growth-related gene expression, growth hormone (GH) receptor 1 (GHR1), upregulated group all Additionally, myostatin (MYST) group. Activities cellular metabolic digestive enzymes improved supplementation, adverse Moreover, bioaccumulation different tissues This highlights through regulation, thereby improving physiological productive performance

Language: Английский

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