ABSTRACT
Coumarins,
a
group
of
naturally
occurring
compounds,
have
been
reported
to
demonstrate
anticancer
potential.
These
substances,
distinguished
by
their
combined
benzene
and
α‐pyrone
rings,
demonstrated
impact
multiple
cellular
mechanisms
essential
for
the
initiation
advancement
cancer.
agents
work
in
different
ways
that
prevent
tumor
cells
from
growing,
spreading,
increasing.
One
main
coumarin
act
is
killing
cancer
through
apoptosis.
This
includes
changes
pro‐
anti‐apoptotic
proteins
like
Bcl‐2
Bax,
release
cytochrome
c
mitochondria,
activation
caspases.
The
suppressor
protein
p53's
expression
has
discovered
be
upregulated
coumarins
such
as
esculetin
imperatorin,
which
encourage
interrupted
cell
cycle
death.
Additionally,
anti‐angiogenic
qualities,
are
critical
development
spread
tumors.
It
can
slow
new
blood
vessels
feed
tumors
inhibiting
“vascular
endothelial
growth
factor
(VEGF)”
route
signaling.
Coumarins
inhibit
number
signaling
pathways
vital
division.
For
example,
they
suppress
“PI3K/mTOR”
pathway,
usually
impairs
results
decreased
viability
growth.
Finally,
could
modulate
response
immune
system
cancerous
cells.
They
ability
boost
activity
natural
killer
cytotoxic
T
lymphocytes,
aid
identifying
eliminating
Through
variety
mechanisms,
regulation,
angiogenesis
reduction,
inhibition,
apoptosis
activation,
exhibit
effects.
molecular
coumarins'
potential
an
interesting
option
novel
treatments.
More
studies
needed
completely
understand
modes
action
maximize
therapeutic
efficacy.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(12), P. 2673 - 2673
Published: Nov. 25, 2023
The
increasing
cases
of
drug
resistance
and
high
toxicity
associated
with
the
currently
used
antifungal
agents
are
a
worldwide
public
health
concern.
There
is
an
urgent
need
to
develop
new
drugs
unique
target
mechanisms.
Plant-based
compounds,
such
as
carvacrol,
eugenol,
coumarin,
cinnamaldehyde,
curcumin,
thymol,
etc.,
have
been
explored
for
development
promising
due
their
diverse
biological
activities,
lack
toxicity,
availability.
However,
researchers
around
world
unable
fully
utilize
potential
natural
products
limitations,
poor
bioavailability
aqueous
solubility.
hybrid
molecules
containing
synthetic
approach
overcome
these
limitations
control
microbes'
capability
resistance.
Based
on
advantages
compounds
improve
activity,
there
different
reported
synthesized
compounds.
This
paper
reviews
literature
report
activities
products.
Journal of Biomolecular Structure and Dynamics,
Journal Year:
2023,
Volume and Issue:
42(3), P. 1392 - 1403
Published: April 10, 2023
The
biological
activity
of
drugs
is
exhibited
due
to
their
interactions
with
bio-receptors.
Dicoumarol
(DIC)
a
natural
hydroxycoumarin
and
well-known
anticoagulant.
DNA
the
genetic
material
one
targets
numerous
drugs.
interaction
DIC
calf-thymus
(ct-DNA)
has
been
studied
using
different
biophysical
techniques
docking
studies.
binding
constant
in
order
103
104
M−1
was
observed
from
spectroscopic
Thermodynamic
studies
at
4
temperatures
revealed
spontaneity
entropy-driven
process.
Marker
displacement
competitive
markers
intercalators
(ethidium
bromide)
groove
binders
(Hoechst
33258)
confirmed
groove-binding
nature
DNA.
mode
complemented
by
like
viscosity
measurements,
melting,
effect
KI
on
binding.
A
minor
perturbation
no
significant
change
melting
temperature
(Tm)
after
further
confirms
mode.
DIC-DNA
system
suggested
absence
intercalation.
electrostatic
force
ionic-strength
study.
Binding-induced
conformational
variation
ct-DNA
absent
circular
dichroism
Molecular
position
within
ct-DNA,
covering
three
base
pairs
long.
outcome
this
report
may
help
understanding
pharmacodynamics
pharmacokinetics
dicoumarol
analogs
related
molecules.Communicated
Ramaswamy
H.
Sarma
Journal of Biomolecular Structure and Dynamics,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 11
Published: Jan. 23, 2024
One
approach
to
accelerate
the
availability
of
new
cancer
drugs
is
test
approved
for
other
conditions
as
anticancer
agents.
During
recent
decades,
penciclovir
(PNV)
has
been
frequently
utilized
a
potent
antiviral
drug,
in
particular
against
infections
caused
by
herpes
viruses.
Many
antivirals
interact
with
DNA
and
change
their
expression
level,
so
determining
binding
mode
great
importance.
In
our
laboratory,
we
have
focused
attention
design
improved
that
target
cellular
DNA,
understand
mechanism
action
at
molecular
also
investigate
effect
The
results
ct-DNA-PNV
interactions
physiological
pH
using
fluorescence
spectroscopy,
UV–visible
absorption
modeling
reveal
this
drug
binds
well
ct-DNA
through
groove
binding.
circular
dichroism
measurements
displayed
PNV
slight
structure
which
affirmed
occurs
mode.
Besides,
multi-spectroscopic
docking
were
used
evaluate
how
interacts
human
serum
albumin
under
conditions.
findings
quenching
suggested
static
was
involved
spontaneous
development
HSA-PNV
complex
hydrophobic
force.
simulation
validated
spectroscopic
techniques.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(2), P. 269 - 269
Published: Feb. 14, 2024
Therapies
for
the
treatment
of
pain
and
inflammation
continue
to
pose
a
global
challenge,
emphasizing
significant
impact
on
patients’
quality
life.
Therefore,
this
study
aimed
investigate
effects
4-(Phenylselanyl)-2H-chromen-2-one
(4-PSCO)
pain-associated
proteins
through
computational
molecular
docking
tests.
A
new
pharmaceutical
formulation
based
polymeric
nanocapsules
was
developed
characterized.
The
potential
toxicity
4-PSCO
assessed
using
Caenorhabditis
elegans
Swiss
mice,
its
pharmacological
actions
acute
nociception
tests
were
also
assessed.
Our
results
demonstrated
that
4-PSCO,
in
free
form,
exhibited
high
affinity
selected
receptors,
including
p38
MAP
kinase,
peptidyl
arginine
deiminase
type
4,
phosphoinositide
3-kinase,
Janus
kinase
2,
toll-like
receptor
nuclear
factor-kappa
β.
Both
nanoencapsulated
showed
no
nematodes
mice.
Parameters
related
oxidative
stress
plasma
markers
change.
treatments
antinociceptive
anti-edematogenic
glutamate
hot
plate
form
more
prolonged
effect,
reducing
mechanical
hypersensitivity
an
inflammatory
model.
These
findings
underscore
promising
as
alternative
development
effective
safer
drugs
inflammation.
Chemistry & Biodiversity,
Journal Year:
2023,
Volume and Issue:
21(3)
Published: Dec. 25, 2023
Abstract
Coumarins,
widely
abundant
natural
heterocyclic
compounds,
are
extensively
employed
in
creating
various
biologically
and
pharmacologically
potent
substances.
The
hybridization
of
heterocycles
presents
a
key
opportunity
to
craft
innovative
multicyclic
compounds
with
enhanced
biological
activity.
Fusing
different
rings
the
coumarin
structure
an
intriguing
method
for
crafting
fresh
hybrid
possessing
remarkable
effects.
In
pursuit
heterocyclic‐fused
coumarins,
wide
range
annulated
heterocyclic[
g
]coumarin
composites
has
been
introduced,
displaying
impressive
potency.
influence
linear
attachment
on
performance
resulting
investigated.
This
review
centers
synthetic
methodologies,
structural
activity
relationship
investigation,
potentials
composites.
We
conducted
searches
across
several
databases,
including
Web
Science,
Google
Scholar,
PubMed,
Scopus.
After
sieving,
we
ultimately
identified
included
71
pertinent
studies
published
between
2000
middle
2023.
will
provide
valuable
perspectives
medicinal
chemists
prospective
design
synthesis
lead
significant
therapeutic
effects,
centered
around
heterocycle‐fused
frameworks.
Polycyclic aromatic compounds,
Journal Year:
2023,
Volume and Issue:
44(5), P. 3576 - 3600
Published: July 21, 2023
Coumarin
and
its
derivatives
are
extensively
used
as
scaffolds
in
the
synthesis
of
novel
heterocyclic
motifs.
In
literature,
several
approaches
especially
involving
metal
metal-free
catalysts
have
been
developed
to
get
biological
potential
coumarin
analogs.
This
review
spotlights
recent
advancements
associated
molecules
recounting
literature
articles
from
2015
middle
2022.
Further,
this
review,
we
focused
on
contents
based
classical
non-classical
methods
for
synthesis.
