Integrated Analysis of Ginsenoside Content and Biomarker Changes in Processed Ginseng: Implications for Anti-Cancer Mechanisms

Foods, Journal Year: 2024, Volume and Issue: 13(16), P. 2497 - 2497

Published: Aug. 8, 2024

Black ginseng is the processed product of ginseng, and it has been found that content types rare ginsenosides increased after processing. However, there limited research on ginsenoside differences between cultivated forest before processing among various plant parts. This study investigated effects in different parts ginseng. After processing, contents Re, Rg1, S-Rg3, Rg5, R-Rh1, Rk1, Rk3, F4 were significantly or decreased, growth age was not proportional to ginsenosides, from cultivation methods relatively small. Chemometric analysis identified biomarkers showing varying percentage changes Network pharmacology predicted EGFR/PI3K/Akt/mTOR pathway as a potential key for anti-cancer effect black

Language: Английский

Comparative untargeted metabolomics analysis of serum metabolic alterations in patients infected with hepatitis B virus genotypes B and C

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(10), P. 105155 - 105155

Published: July 11, 2023

The clinicopathological characteristics and outcomes of patients infected with hepatitis B virus (HBV) differ between genotypes C. However, the potential metabolic mechanisms differences in certain biological pathways associated different HBV remain unclear to date. To obtain a better understanding effects liver diseases caused by C on host metabolism, an untargeted metabolomics analysis was performed assess among serum profiles healthy controls or Here, total 54 samples were obtained from chronic infections C, subjected analysis. metabolite analyzed using ultrahigh-performance liquid chromatography-quadrupole-time-of-flight/mass spectrometry (UHPLC-Q-TOF/MS)-based approach for identifying differentially expressed metabolites that upregulated downregulated at least 1.5-foldin A 63 found be genotype B, while 57 majority these involved regulating bile acid (BA) metabolism pathways. results also indicated 8 can serve as biomarkers distinguishing individuals Altogether, revealed infection is profiles, study provided fundamental information further detailed investigations mechanism underlying dysregulation infections.

Language: Английский

Effects of Low-Salinity Stress on Histology and Metabolomics in the Intestine of Fenneropenaeus chinensis

Animals, Journal Year: 2024, Volume and Issue: 14(13), P. 1880 - 1880

Published: June 26, 2024

Metabolomics has been used extensively to identify crucial molecules and biochemical effects induced by environmental factors. To understand the of acute low-salinity stress on

Language: Английский