Stomatology,
Journal Year:
2024,
Volume and Issue:
103(6), P. 58 - 58
Published: Jan. 1, 2024
The
review
considers
methods
of
manufacturing
photopolymerizable
compositions
for
bone
tissue
repair,
as
well
polymers
and
photoinitiators
used
this
purpose.
Their
physical
biological
properties
are
described.
Examples
light-curing
in
biomedicine
engineering
given.
prospects
photopolymerization
development
the
production
materials
regeneration
a
promising
technology
application
dentistry,
maxillofacial
surgery
orthopedics
considered.
Caderno Pedagógico,
Journal Year:
2025,
Volume and Issue:
22(1), P. e13127 - e13127
Published: Jan. 8, 2025
Os
custos
elevados
do
tratamento
de
lesões
epiteliais,
a
crescente
resistência
microbiana
e
os
efeitos
colaterais
terapias
convencionais
destacam
necessidade
novas
abordagens
terapêuticas.
Nesse
cenário,
bioprospecção
compostos
bioativos
produtos
biotecnológicos
ganham
relevância.
Biomateriais
como
polissacarídeos
têm
apresentado
excelente
destaque.
E
formulações
hidrogéis,
que
podem
funcionar
sistemas
administração
medicamentos
curativos
inteligentes
respondem
estímulos
pH,
temperatura
luz,
revelam
ser
aplicações
importantes,
mundialmente.
Entre
suas
possíveis
combinações
promissoras
estão
probióticos,
principalmente
as
bactérias
ácido-láticas,
apresentam
potencial
para
estimular
o
sistema
imunológico
combater
vírus,
fungos.
Um
exemplo
interessante
polímero
desenvolvimento
probióticos
tópicos
é
goma
guar,
derivada
da
semente
leguminosa
Cyamopsis
tetragonolobus,
se
destaca
por
um
polissacarídeo
hidrofílico
com
propriedades
gelificantes
espessantes.
Tais
necessitam
apresentar
efetivo
controle
segurança
seus
usos,
qualidade
avaliada
pela
análise
toxicidade
dérmica,
partir
dos
resultados
testes
in
vivo,
em
camundongos,
exemplo.
O
presente
estudo
buscou
avaliar
dérmica
uma
formulação
desenvolvida
hidrogel
à
base
guar
contendo
Lactiplantibacillus
plantarum
M2.
A
metodologia
empregada,
envolveu
avaliação
formulação,
dose
repetida,
análises
parâmetros
hematológicos
bioquímicos
ainda
histopatológicas
pele
tratada
camundongos.
indicaram
ausência
irritação,
ou
alterações
hematológicas
histopatológicas,
reforçando
eficácia
formulação.
Advanced Materials Interfaces,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 2, 2025
Abstract
Radiation
combined
wound
injury
(RCWI)
presents
significant
healing
challenges
due
to
radiation‐induced
immune
suppression,
organ
dysfunction,
and
disruption
of
growth
factors
extracellular
matrix
dynamics.
Conventional
dressings
like
gauze
are
inadequate
for
these
complex
injuries.
Hydrogels
have
emerged
as
a
promising
solution
skin
mucosal
injuries,
offering
superior
mechanical
strength,
cell‐regeneration
support,
multifunctional
biochemical
properties,
including
antimicrobial,
antioxidant,
adhesive
capabilities.
They
create
moist,
biocompatible
environment
that
promotes
cell
proliferation,
migration,
tissue
repair,
while
enabling
sustained
drug
delivery,
free
radical
scavenging,
inflammation
Deoxyribonucleic
acid
(DNA）
repair.
Despite
their
potential,
systematic
comparison
radiation
injuries
remains
lacking.
This
review
addresses
this
gap
by
focusing
on
hydrogels
supportive
matrices
therapeutic
enhancers,
exploring
radiation‐impaired
mechanisms,
highlighting
hydrogel
advancements,
comparing
efficacy
in
common
versus
wounds.
It
also
provides
future
research
directions
clinical
practice
insights,
emphasizing
the
potential
RCWI
treatment.
By
bridging
current
knowledge
gaps,
aims
guide
improve
practices
radiology
trauma
medicine.
Biomacromolecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
Bioactive
hydrogels
are
garnering
increasing
interest
in
wound
management
due
to
their
porous
structural
features
and
versatile
intrinsic
biological
activities.
Importantly,
the
antibacterial
capacity
is
a
crucial
requirement
for
hydrogel
dressings
chronically
infected
wounds.
In
this
study,
we
report
an
constructed
from
silk
sericin
(SS)
cross-linked
with
glycyrrhizic
acid
(GA)
integrated
silver
ions
(Ag+)
accelerate
healing
of
bacterial-infected
The
resultant
sericin-glycyrrhizic
acid-Ag+
(SGA)
demonstrates
favorable
mechanical
properties,
effectively
preventing
secondary
injury
Moreover,
vitro
studies
indicated
that
SGA
possesses
excellent
swelling
ratios,
degradability,
cytocompatibility,
promoting
cell
growth
proliferation.
Notably,
exhibited
effective
activity
against
both
Gram-positive
Gram-negative
bacteria
through
release
Ag+.
Staphylococcus
aureus-infected
model,
efficiently
eradicated
bacteria,
thus
repair.
Overall,
our
work
establishes
novel
strategy
developing
multifunctional
based
on
natural
materials
managing
bacteria-infected
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Abstract
Herpes
simplex
virus
type
1
(HSV‐1)
is
a
prevalent
human
pathogen
primarily
transmitted
through
skin‐to‐skin
contact.
Traditional
antiviral
drugs
like
acyclovir
(ACV)
have
limitations
due
to
viral
resistance
and
side
effects,
necessitating
the
development
of
alternative
therapeutic
strategies.
Drug‐loaded
hydrogels
emerged
as
promising
approach
for
managing
various
skin
infections.
Considering
low‐pH
microenvironment
following
HSV‐1
infection,
pH‐responsive
baicalein@chitosan
(B@C)
hydrogel
developed
topical
treatment
This
synthesized
by
incorporating
baicalein,
natural
flavonoid,
into
chitosan
matrix
modified
with
4‐formylphenylboronic
acid
protocatechualdehyde
achieve
potent
anti‐HSV‐1
activity
pH‐responsiveness.
In
vitro
results
demonstrated
hydrogel's
pH‐dependent
inhibitory
effect
on
infections,
including
ACV‐resistant
strains.
Subsequent
investigations
confirmed
its
efficacy
in
multiple
murine
infection
models.
Mechanistically,
B@C
inhibited
replication
modulating
phosphorylation
inhibitor
nuclear
factor
kappa‐B
kinase
subunit
beta,
promoted
collagen
synthesis,
decreased
reactive
oxygen
species
generation.
Ultra‐high‐performance
liquid
chromatography‐tandem
mass
spectrometry
analysis
revealed
sustained
release
baicalein
from
hydrogel,
ensuring
long‐term
drug
retention
HSV‐1‐infected
tissues.
Collectively,
these
findings
suggest
that
holds
significant
potential
management
