Association between complete blood count-derived inflammatory markers and the risk of frailty and mortality in middle-aged and older adults

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: July 31, 2024

Objective This study aimed to evaluate the association between six complete blood count (CBC)-derived inflammatory markers [neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), systemic immune-inflammatory index (SII), response (SIRI), and pan-immune inflammation value (PIV)] risk of frailty mortality. Methods Data were obtained from National Health Nutrition Examination Survey (NHANES) 1999–2018. Mortality was identified using Death Index until December 31, 2019. Multiple logistic regression analysis conducted CBC-derived frailty. The Cox model assessed mortality in frail populations. Restricted cubic spline (RCS) used visualize with risk. predictive for further a random survival forest (RSF) approach. Results analyzed data total 16,705 middle-aged older participants. Among them, 6,503 participants frail, rate 41.47%. showed that NLR, MLR, PLR, SII, SIRI, PIV positively associated revealed highest quartile had significantly increased death compared those lowest quartile: NLR (HR = 1.73, 95% CI:1.54, 1.94), MLR 1.71, CI:1.51, 1.93), PLR 1.28, 95%CI: 1.15, 1.43), SII 1.50, 95%CI:1.34, 1.68), SIRI 1.88, CI 95%:1.67, 2.12), 1.55, 95%CI:1.38, 1.73). Random analyses demonstrated adult Conclusion results suggest are higher as well middle old-aged population United States.

Language: Английский

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The association of urinary heavy metal exposure with frailty susceptibility and mortality in middle-aged and older adults: a population-based study

Archives of Public Health, Journal Year: 2024, Volume and Issue: 82(1)

Published: March 27, 2024

Abstract Heavy metals’ presence as environmental pollutants has a close link to adverse health effects. Frailty, clinical syndrome hallmarked by elevated vulnerability stressors, presents substantial challenge in healthcare. However, the association between exposure heavy metals and frailty largely remains unexplored. Utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 2003–2018 correlated with U.S. Death Index (NDI) 2019, we investigated mortality outcomes. Logistic regression, Cox Kaplan-Meier survival curves, weighted quantile-sum (WQS) Bayesian kernel machine regression (BKMR) were employed assess metal incidence frail population. Eight measured urine using inductively coupled plasma mass spectrometry values adjusted for urinary creatinine, which was used reflect exposure. The cohort incorporated 5370 female participants aged 45 above, 1518 diagnosed frailty. findings indicated correlation specific metals, namely tungsten (odds ratio [OR]: 1.94, 95% confidence interval [CI]: 1.31–2.89), cobalt (OR: 1.64, CI: 1.40–1.93), cadmium 1.93, 1.52–2.43), uranium 7.36, 1.53–35.28), an risk of WQS BKMR models identified cadmium, cobalt, main contributors analysis, after adjustment covariates, suggested that higher levels lead, death patients, associated hazard ratios (HR) 1.96 (1.53, 2.52) 1.30 (1.13, 1.49), respectively. Our study revealed significant positive mixtures onset middle-aged older adults, along increased patients. Cobalt, emerged prominent frailty, directly impacting long-term life expectancy

Language: Английский

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Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(12), P. 2199 - 2216

Published: Oct. 14, 2024

Language: Английский

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Association of systemic immune-inflammatory index with all-cause and cancer mortality in Americans aged 60 years and older

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: March 10, 2025

Background This research delved into the association between systemic immune-inflammatory index (SII) and both all-cause cancer-specific mortality among individuals aged 60 years above in United States during period from 1999 to 2018, with follow-up extending until 31 December 2019. The data utilized was sourced 4295 population-based participants National Health Nutrition Examination Survey (NHANES). Methods To analyze relationship SII mortality, study employed Cox proportional-risk models, restricted cubic spline curves, survival subgroup analyses. Results average age of 70.7 (±7.6) years, median duration 131.7 (±59.8) months, rate stood at 50.5%. Findings regression model indicated that, after adjusting for covariates, significantly linearly related (hazard ratio HR = 1.31, 95% confidence interval CI 1.15–1.48). Moreover, cancer exhibited a U-shaped pattern. curves suggested that higher associated an augmented risk mortality. Conclusion There is significant levels increased US population older.

Language: Английский

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Inverse L-shaped association of triglyceride glucose index with all-cause and cerebral cardiovascular-related mortality in osteoarthritis patients: a cohort of 4145 patients

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

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Associations between naples prognostic score and stroke and mortality among older adults

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 24, 2025

Language: Английский

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