The Indissociable Triad: Vascular Impairment, Muscle Atrophy, and Cognitive Decline

Published: Aug. 12, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating mass reduction seen in sarcopenia the neuronal functions characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review ana-lyzes interrelated mechanisms contribute to these conditions, with a specific focus on ox-idative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting sar-copenia characterized by atrophy weakness. dysfunction have negative physical function quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing oxidative in-flammation, integrated therapies improving muscular well-being. Better links can refine strategies yield better patient out-comes. study emphasizes complex interplay between dysfunction, de-generation, decline, highlighting necessity for multidisciplinary ap-proaches. Advances domain promise improved diagnostic accuracy, more thera-peutic options, enhanced preventive measures, all contributing higher life elderly population.

Language: Английский

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Safeguarding vitality and cognition: The role of sarcopenia in intrinsic capacity decline among octogenarians from multiple cohorts

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(6), P. 100268 - 100268

Published: May 28, 2024

Sarcopenia and intrinsic capacity (IC) declines pose significant challenges to healthy aging, particularly in the rapidly growing octogenarian population. This study aimed elucidate relationship between sarcopenia IC across multiple cohorts of community-dwelling older adults.

Language: Английский

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Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2096 - 2096

Published: Sept. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Language: Английский

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Pathological and Inflammatory Consequences of Aging

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 404 - 404

Published: March 12, 2025

Aging is a complex, progressive, and irreversible biological process that entails numerous structural functional changes in the organism. These affect all bodily systems, reducing their ability to respond adapt environment. Chronic inflammation one of key factors driving development age-related diseases, ultimately causing substantial decline abilities older individuals. This persistent inflammatory state (commonly known as “inflammaging”) characterized by elevated levels pro-inflammatory cytokines, an increase oxidative stress, perturbation immune homeostasis. Several factors, including cellular senescence, contribute this milieu, thereby amplifying conditions such cardiovascular disease, neurodegeneration, metabolic disorders. Exploring mechanisms chronic aging essential for developing targeted interventions aimed at promoting healthy aging. review explains strong connection between inflammation, highlighting potential therapeutic approaches like pharmacological treatments, dietary strategies, lifestyle changes.

Language: Английский

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Circuit training intervention for cognitive function, gut microbiota, and aging control: study protocol for a longitudinal, open-label randomized controlled trial

Trials, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 18, 2025

Abstract Background Long-term exercise is increasingly considered an effective strategy to counteract cognitive decline associated with aging. Previous studies have indicated that circuit training exercises integrating aerobic and resistance modalities positively affect function. Furthermore, a growing body of evidence suggests long-term alters the gut microbiota, leading optimal environment for enhancement. Recent empirical plays significant role in modulating aging-control factors at protein level. Although interaction between function multifaceted, most only examined direct pathway from Therefore, this study aims elucidate effects on through comprehensive analysis such as microbiota proteins related aging control. Methods A total fifty-one participants will be randomly assigned either or waitlist control group. The intervention group participate program developed by Curves Japan Co., Ltd. two three times weekly 16 weeks. continue their usual daily routines without participating any new active lifestyle program. undergo assessments baseline after intervention. Fecal blood samples collected before effect cognition analyzed comparing measured outcomes associations among these assessed using linear mixed model structural equation modeling approaches. Discussion This provide first insights into perspectives findings are expected contribute improving brain health combating age-related decline. may help establish guidelines future relationship

Language: Английский

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GLIS roadmap: the quest for international standardization of sarcopenia diagnosis

Archives of Gerontology and Geriatrics, Journal Year: 2024, Volume and Issue: 123, P. 105464 - 105464

Published: May 1, 2024

Language: Английский

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Differences in lean mass and sarcopenia between individuals with Alzheimer's disease and those without dementia: A systematic review and meta-analysis of observational studies

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Studies have observed that individuals with Alzheimer's disease (AD) tend to lower lean mass and higher rates of sarcopenia.

Language: Английский

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