Longitudinal patterns of cognitive function and depression: insights from the China Health and Retirement Longitudinal Study

Journal of Global Health, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 28, 2025

Abstract Background With the acceleration of population aging, cognitive impairment and depression have become serious public health challenges in countries around world. The influencing factors trajectory, dual trajectories middle-aged elderly adults not been fully studied. Methods This study used data from China Health Retirement Longitudinal Study database spanning 2011–2018. Group-based trajectory modelling group-based were employed to examine different trajectories. Restricted cubic spline multivariate logistic regression analysis elucidate relationship between sleep duration grip strength with these Mediation was conducted explore mediating roles activities daily living (ADLs) their impact on Results Trajectory identified two longitudinal patterns function scores: low high group, respectively, states cognition depression: stable state group decline group. Sleep associated has an inverted U-shaped trajectory. Grip nonlinearly above mediation effects association ADLs cognitive, 3.14, 6.14, 2.70%. While 7.21, 1.67 6.24%, respectively (P < 0.05). Conclusions only depression, trajectories, but also partially mediate will provide a basis for how intervene mental adults.

Language: Английский

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Association of combined left and right handgrip strength with new-onset chronic kidney disease in middle-aged and older adults: a nationwide multicenter cohort study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 13, 2025

The role of multi-site muscle strength in the incidence chronic kidney disease (CKD) remains largely unknown. This study aims to investigate association combined left and right handgrip (CHS) with new-onset CKD middle-aged older adults. observational multicenter included 4618 community-dwelling adults without at baseline 2011. CHS (kg) was assessed participants were followed 2013, 2015, 2018 track incidents. Sex-specific thresholds for low determined using receiver operating characteristic (ROC) analysis. Restricted cubic spline analysis, survival analysis multivariable-adjusted Cox regression models used analyze between CKD. 2526 women 2092 men (median age = 58.87 years). During seven-year follow-up, 503 (10.89%) new cases occurred. associated both (P 0.021) 0.009) a linear-like manner (both P nonlinearity > 0.05). optimal predict incidents 96.15 kg 57.90 women. Kaplan-Meier curves demonstrated that prolonged positively < 0.001) 0.001). Low CHS, defined thresholds, independently an increased risk (HR 1.824, 95% CI 1.379 2.413). relationship strengthened BMI classification normal 2.878, 1.732 4.782, interaction 0.032) baseline, as well those diabetes 2.048, 1.514 2.771, 0.019). longitudinal Chinese These findings highlight potential early-life interventions prevention

Language: Английский

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Handgrip weakness and overall life satisfaction decline: derivation of cutoff values and analysis of sex differences in older Chinese adults

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 18, 2025

Handgrip strength (HGS) is a cost-effective indicator of skeletal muscle function. However, the sex-specific association between HGS and life satisfaction decline among older Chinese adults remains largely unknown. This observational, cross-sectional multicenter study included 3,649 (age range: 60-101 years) from nationally representative survey in China. Overall was determined using score (LSS). Correlations variables were examined Spearman's correlation analysis. Receiver operating characteristic (ROC) curves utilized to determine cutoffs for predicting LSS. Restricted cubic spline (RCS) analysis multivariate logistic regression employed investigate associations low 1,762 women 1,887 men (median age = 68.3 years). LSS observed 485 (13.3%) participants. positively correlated with both (both P < 0.05). Individuals associated higher rate (16.2% vs. 10.8%, 0.001). RCS demonstrated linear-like (P 0.001, nonlinear 0.099), but not 0.110, 0.329). ROC revealed that optimal cutoff indicating presence 27.5 kg 22.3 women. Multivariable showed participants had odds experiencing [odds ratios (OR) 1.509, 95% confidence interval (CI) 1.218-1.867]. only (OR 1.871, CI 1.358-2.562, 0.001), while it attenuated 1.281, 0.964-1.701, 0.087). establishes identifying adults. Low manner, These findings might facilitate development strategies promote healthy aging.

Language: Английский

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