Accelerated biological aging mediates the association between inflammatory markers with Helicobacter pylori infection and mortality

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 10, 2025

The aim of this study was to explore the systemic inflammation response in relation mortality Helicobacter pylori (H. pylori) infection, and whether relationship mediated by accelerated biological aging. This cross-sectional encompassed U.S. participants from National Health Nutrition Examination Survey (NHANES) 1999–2000. Kaplan-Meier survival curve, Cox regression analysis, K-means clustering, mediation analysis restricted cubic spline (RCS) were used relationships between inflammatory markers, aging, H. infection all-cause mortality. A total 3509 enrolled form NHANES Compared with seronegative participants, seropositive had significantly higher (P < 0.001). Among these both phenotypic age acceleration (PhenoAgeAccel) positively associated increased levels significant indirect effect markers (neutrophil count index (SIRI)) on through PhenoageAccel found, proportions 50.0% 49.1%, respectively. elevation blood is an risk among population, aging might be one its mechanisms.

Language: Английский

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Biological age prediction and NAFLD risk assessment: a machine learning model based on a multicenter population in Nanchang, Jiangxi, China

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 13, 2025

Language: Английский

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Joint association of frailty index and biological aging with all-cause and cause-specific mortality: a population-based longitudinal cohort study

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: unknown, P. 105856 - 105856

Published: April 1, 2025

The role of frailty in all-cause, cardiovascular, and cancer mortality is debatable, the modification effect biological aging remains unclear. Therefore, we aimed to evaluate joint association index with all-cause cause-specific mortality. In this population-based cohort study, data were obtained from National Health Nutrition Examination Survey (NHANES) Death Index (NDI). Demographic variables extracted, was constructed, calculated. All-cause deaths, cardiovascular disease (CVD) deaths extracted as outcomes. Cox proportional hazards regression models used estimate correlations, stratified subgroup analyses figure out modifiers, sensitivity confirm robustness. A total 22,729 NHANES participants included 6786 1830 CVD 1396 occurred during an average follow-up 8.5 years over a 192,601 person-years. hazard ratios (HRs) delayed group for mortality, 0.45 (95 % CI: 0.41-0.49), 0.39 0.34-0.45), 0.54 0.46-0.63), respectively, compared accelerated (P all comparisons < 0.001). Likewise, score positively associated (HR, 1.06 [95 CI, 1.06-1.06] per 0.01 increase index), 1.07 1.06-1.07] 1.04 1.03-1.04] index). associations modified by interaction = 0.044), but not 0.482). Accelerated higher index, whereas inversely risk Biological among These findings suggest that people high acceleration aging, lower degree decrease approaches such lifestyle modifications might be beneficial individual's longevity lifespan.

Language: Английский

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Association of advanced lung cancer inflammation index with all-cause and cardiovascular mortality in metabolic dysfunction associated steatotic liver disease

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 29, 2025

Language: Английский

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