Research progress of metalloporphyrin against neurodegen-erative diseases DOI Creative Commons
Jie Chen, Jing Lu,

Qingyi Wang

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Neurodegenerative disorders are a group of diseases caused by the degeneration and apoptosis neurons in brain spinal cord, which seriously affect human ability motion perception, memory cognition. Peroxynitrite can cause oxidative damage exhibiting neurotoxicity, its excussive accumulation is closely related to neurodegenerative diseases. Therefore, effectively scavenging peroxynitrite may become therapeutic strategy for Due their high ability, some water-soluble metalloporphyrins have recently attracted much attention. Metalloporphyrins such as iron porphyrins manganese certain neuroprotective effects, including inhibiting amyloid plaque accumulation, alleviating stress neuroinflammatory damage, improving mitochondrial function reducing neuronal apoptosis. However, there limitations drugs, metal poor blood-brain barrier penetration. To overcome obstacle, addition traditional synthesis processes, also be prepared into nanoparticles improve bioavailability

Language: Английский

Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease DOI
Shivani Chib, Bhaskar Jyoti Dutta, Rishabh Chalotra

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

With the passage of time, people step toward old age and become more prone to several diseases associated with age. One such is Alzheimer's disease (AD) which results into neuronal damage dementia progression The existing therapeutics has been hindered by various enkindles like less eminent between remote populations, affordability issues toxicity profiles. Moreover, lack suitable therapeutic option further worsens quality life in older population. Developing an efficient intervention cure AD still a challenge for medical fraternity. Recently, alternative approaches attain attention researchers focus on plant-based therapy mitigating AD. In this context, flavonoids gained centrality as feasible treatment modifying neurological deficits. This review mainly focuses pathological facets economic burden Furthermore, we have explored possible mechanism preclinical clinical aspects curing Flavonoids being potential therapeutic, target pathogenic factors oxidative stress, inflammation, metal toxicity, Aβ accumulation, modulate neurotransmission insulin signaling. review, emphasized neuroprotective effects pathology, both experimental findings. While studies suggest promising benefits, data remains limited inconclusive. Thus, high-quality trials are necessary validate efficacy study aim promote therapies encourage add regular diet avail beneficial preventive

Language: Английский

Citations

7
Advances in Understanding Biomarkers and Treating Neurological Diseases -Role of the Cerebellar Dysfunction and Emerging Therapies DOI
Azhagu Madhavan Sivalingam

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102519 - 102519

Published: Sept. 1, 2024

Language: Английский

Citations

5
Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer’s Disease, a Potential Therapeutic Target DOI Creative Commons
Nidhi Puranik, Minseok Song

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5744 - 5744

Published: Dec. 5, 2024

Gamma-glutamate is an important excitatory neurotransmitter in the central nervous system (CNS), which plays role transmitting synapses, plasticity, and other brain activities. Nevertheless, alterations glutamatergic signaling pathway are now accepted as a element Alzheimer's disease (AD) pathophysiology. One of most prevalent types dementia older adults AD, progressive neurodegenerative illness brought on by persistent decline cognitive function. Since AD has been shown to be multifactorial, variety pharmaceutical targets may used treat condition. N-methyl-D-aspartic acid receptor (NMDAR) antagonists acetylcholinesterase inhibitors (AChEIs) two drug classes that Food Drug Administration authorized for treatment AD. The AChEIs approved galantamine, donepezil, rivastigmine. However, memantine only non-competitive NMDAR antagonist This review aims outline involvement glutamate (GLU) at molecular level pathways associated with demonstrate target therapeutic potential its receptor. We will also consider opinion leading authorities working this area, drawback existing strategies, direction further investigation.

Language: Английский

Citations

5
Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging DOI Creative Commons
Maggie Pecsok, Heather Robinson,

Ally Atkins

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Introduction Hippocampal glutamate (Glu) dysfunction is a pertinent indicator of neurodegeneration, yet mapping typical age-related changes in Glu has been challenging. Here, we use 7T MRI approach, Glutamate Chemical Exchange Saturation Transfer (GluCEST), to measure bilateral hippocampal healthy old (HOA) and young (HYA) adults. Methods Bilateral GluCEST data was acquired from 27 HOA 22 HYA using MRI. differences by age hemisphere were tested with linear mixed model. asymmetry index also evaluated age. Exploratory analyses examined associations between GluCEST, group, scores on the Montreal Cognitive Assessment (MoCA) Complaints Index (CCI). Results levels showed an group interaction. In HOA, higher left than right hippocampus, but HYA, level equivalent across hemispheres. had lower hippocampus. confirmed significant HOA. Lower associated subjective cognitive complaints as measured CCI. Discussion provides insight into neural changes, hippocampus older These findings offer step toward elucidating asymmetrical trajectory glutamatergic alterations their relationship phenotypes.

Language: Английский

Citations

0
The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection DOI Creative Commons
Xu Wang,

Chunshu Rong,

Ping Niu

et al.

Frontiers in Toxicology, Journal Year: 2025, Volume and Issue: 7

Published: Jan. 27, 2025

IAA is a by-product of the water disinfection process and has been found to be neurotoxic. However, role mechanism neurotoxicity remain unclear. In this review, we comprehensively discuss neurotoxic effects mechanisms from molecular level, cellular level neurological manifestations. At causes by reducing mitochondrial membrane potential, aggravating oxidative stress DNA damage. inducing BBB disruption, neuroinflammation, apoptosis. manifestations, can lead neurotransmitter disorders, neurodevelopment dysfunction, even neurodegenerative diseases. Taken together, our review provides insights into that will contribute future studies its protective strategies.

Language: Английский

Citations

0
Predictive value of biliverdin reductase‐A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes DOI Creative Commons
Sheng Li, Xue‐biao Wei, Nan Wang

et al.

Journal of Diabetes Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

ABSTRACT Aims/Introduction To investigate the predictive value of biliverdin reductase‐A (BVR‐A) and homeostasis model assessment for insulin resistance (HOMA‐IR) on mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus, to establish a nomogram model. Materials Methods This study included 140 mellitus. Based Montreal Cognitive Assessment (MoCA) scores, participants were categorized into normal function (T2DM‐NCF) group (65 cases) (T2DM‐MCI) (75 cases). Multivariate logistic regression analysis was performed identify factors associated MCI A prediction developed using R software selected factors, its predictability accuracy verified. Results Compared T2DM‐NCF group, subjects older, had longer duration diabetes, higher HOMA‐IR, lower BVR‐A, education levels (all P < 0.05). showed that (OR = 1.407, 95% CI: 1.163–1.701), HOMA‐IR 1.741, 1.197–2.53), BVR‐A 0.528, 0.392–0.712) significantly development The C‐index 0.863 (95% 0.752–0.937). Conclusions Our findings suggest are incorporating aids predicting risk developing these patients.

Language: Английский

Citations

0
Changes in the Properties of Ethanol-Sensitive Molecular Targets During Maturation and Aging DOI
Luis G. Aguayo, Lorena Armijo‐Weingart, Loreto San Martín

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 299 - 316

Published: Jan. 1, 2025

Language: Английский

Citations

0
Red Panax ginseng root promotes neuronal plasticity in vitro and improves cognitive function in aged animals DOI Open Access
Camille Lelong,

Antoine Mandoux,

Nicolas Houyoux

et al.

Functional Foods in Health and Disease, Journal Year: 2024, Volume and Issue: 14(8), P. 574 - 588

Published: Aug. 8, 2024

Background: Cognitive function declines with aging, primarily due to reduced neuronal plasticity, decreased release of trophic factors, and stress. Genetic environmental factors have been shown impact cognitive function. Diets enriched neuroactive ingredients proposed support functions in humans. Several compounds, including ginsenosides, identified Panax ginseng. Many studies show that the roots this plant promote neuroprotection neuroplasticity. Objective: The aim study was examine red ginseng cultivated an innovative vertical farming technology. effects were investigated determine whether they could (1) plasticity survival during stress vitro (2) improve (short-term memory) vivo. Methods: An extract Botalys root powder tested on primary hippocampal cortical neurons, injured or not, glutamate. Its neuritogenesis synaptogenesis as well its neuroprotective efficacy. Moreover, effect vivo aged animals. Results: results demonstrated prolonged treatment neurons significantly prompts synapse formation neurite elongation cultures neurons. In addition, protected from glutamate-induced excitotoxicity a culture aging mice, oral administration for 7 days improved short-term memory deficit associated aging. Conclusion: Altogether, these indicate promotes models improves deficits Keywords: ginseng, functions, vitro,

Language: Английский

Citations

0
Research progress of metalloporphyrin against neurodegen-erative diseases DOI Creative Commons
Jie Chen, Jing Lu,

Qingyi Wang

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Neurodegenerative disorders are a group of diseases caused by the degeneration and apoptosis neurons in brain spinal cord, which seriously affect human ability motion perception, memory cognition. Peroxynitrite can cause oxidative damage exhibiting neurotoxicity, its excussive accumulation is closely related to neurodegenerative diseases. Therefore, effectively scavenging peroxynitrite may become therapeutic strategy for Due their high ability, some water-soluble metalloporphyrins have recently attracted much attention. Metalloporphyrins such as iron porphyrins manganese certain neuroprotective effects, including inhibiting amyloid plaque accumulation, alleviating stress neuroinflammatory damage, improving mitochondrial function reducing neuronal apoptosis. However, there limitations drugs, metal poor blood-brain barrier penetration. To overcome obstacle, addition traditional synthesis processes, also be prepared into nanoparticles improve bioavailability

Language: Английский

Citations

0