Frontiers in Oncology,
Journal Year:
2021,
Volume and Issue:
11
Published: July 29, 2021
Over
decades
of
studies,
accumulating
evidence
has
suggested
that
epigenetic
dysregulation
is
a
hallmark
tumours.
Post-translational
modifications
histones
are
involved
in
tumour
pathogenesis
and
development
mainly
by
influencing
broad
range
physiological
processes.
Histone
deacetylases
(HDACs)
histone
acetyltransferases
(HATs)
pivotal
modulators
regulate
dynamic
processes
the
acetylation
at
lysine
residues,
thereby
transcription
oncogenes
suppressor
genes.
Moreover,
HDACs
mediate
deacetylation
process
many
nonhistone
proteins
thus
orchestrate
host
pathological
processes,
such
as
pathogenesis.
In
this
review,
we
elucidate
functions
cancer.
Clinical Proteomics,
Journal Year:
2025,
Volume and Issue:
22(1)
Published: Feb. 17, 2025
To
investigate
the
association
between
admission
glucose
and
HbA1c
values
inflammatory
plasma
proteins
in
hospitalized
patients
with
acute
ST-elevation
myocardial
infarction
(STEMI).
This
analysis
was
based
on
345
STEMI
recorded
by
population-based
Myocardial
Infarction
Registry
Augsburg
2009
2013.
Using
OLINK
panel,
a
total
of
92
protein
biomarkers
were
measured
arterial
blood
samples,
which
obtained
within
scope
cardiac
catheterization
immediately
after
admission.
The
associations
levels
markers
investigated
using
multivariable
linear
regression
models.
Admission
showed
significantly
positive
IL-10,
IL-8,
IL-6,
FGF-21,
IL-7,
ST1A1,
MCP-1,
4E-BP1,
SIRT2,
STAMBP
IL-18R1
Bonferroni
adjustment.
only
associated
IL-18R1.
In
stratified
analyses,
not
any
diabetes
subgroup,
while
there
several
that
without
known
diabetes,
namely
CCL20,
MCP-1
IL-6.
due
to
an
seems
be
related
immune-related
response,
expressed
increase
inflammation-related
particular
non-diabetic
stress
hyperglycemia.
present
results
may
open
new
avenues
for
development
suitable
as
potential
diagnostic
or
prognostic
clinical
markers.
Frontiers in Oncology,
Journal Year:
2020,
Volume and Issue:
10
Published: Sept. 8, 2020
Sirtuin
2
(SIRT2)
is
a
member
of
the
sirtuin
protein
family.
It
Class
III
histone
deacetylase
(HDACs)
and
predominantly
localized
to
cytosol.
SIRT2
deacetylates
histones
number
non-histone
proteins
plays
pivotal
role
in
various
physiologic
processes.
Previously,
has
been
considered
indispensable
during
carcinogenesis,
however,
there
now
significant
controversy
regarding
whether
an
oncogene
or
tumor
suppressor.
The
purpose
this
review
summarize
physiological
functions
its
mechanisms
cancer.
We
will
focus
on
five
malignancies
(breast
cancer,
non-small
cell
lung
hepatocellular
carcinoma,
colorectal
cancer
glioma)
describe
current
status
research
discuss
clinical
evaluation
expression
use
inhibitors.
Cells,
Journal Year:
2021,
Volume and Issue:
10(8), P. 1930 - 1930
Published: July 29, 2021
In
Alzheimer’s
disease
(AD),
the
contribution
of
pathophysiological
mechanisms
other
than
amyloidosis
and
tauopathy
is
now
widely
recognized,
although
not
clearly
quantifiable
by
means
fluid
biomarkers.
We
aimed
to
identify
protein
biomarkers
reflecting
neuroinflammation
in
AD
using
multiplex
proximity
extension
assay
(PEA)
testing.
Cerebrospinal
(CSF)
samples
from
patients
with
mild
cognitive
impairment
due
(AD-MCI)
controls,
i.e.,
neurological
diseases
(OND),
were
analyzed
Olink
Inflammation
PEA
biomarker
panel.
A
machine-learning
approach
was
then
used
discriminating
AD-MCI
(n:
34)
OND
25).
On
univariate
analysis,
SIRT2,
HGF,
MMP-10,
CXCL5
showed
high
discriminatory
performance
(AUC
0.809,
p
=
5.2
×
10−4,
AUC
0.802,
6.4
0.793,
3.2
10−3,
0.761,
2.3
respectively),
higher
CSF
levels
as
compared
controls.
These
same
proteins
best
contributors
penalized
logistic
regression
model
controls
0.906,
2.97
10−7).
The
biological
processes
regulated
these
include
astrocyte
microglia
activation,
amyloid,
tau
misfolding
modulation,
blood-brain
barrier
dysfunction.
Using
a
high-throughput
analysis
coupled
statistical
approach,
we
identified
novel
AD.
Studies
confirming
results
different
assays
are
needed
validate
technique
for
discovery
field
diseases.
Frontiers in Oncology,
Journal Year:
2021,
Volume and Issue:
11
Published: July 29, 2021
Over
decades
of
studies,
accumulating
evidence
has
suggested
that
epigenetic
dysregulation
is
a
hallmark
tumours.
Post-translational
modifications
histones
are
involved
in
tumour
pathogenesis
and
development
mainly
by
influencing
broad
range
physiological
processes.
Histone
deacetylases
(HDACs)
histone
acetyltransferases
(HATs)
pivotal
modulators
regulate
dynamic
processes
the
acetylation
at
lysine
residues,
thereby
transcription
oncogenes
suppressor
genes.
Moreover,
HDACs
mediate
deacetylation
process
many
nonhistone
proteins
thus
orchestrate
host
pathological
processes,
such
as
pathogenesis.
In
this
review,
we
elucidate
functions
cancer.
