The impacts of household factors and proxies of human social determinants of health on dog behavior DOI Creative Commons
Lauren Powell, Darko Stefanovski, Nancy A. Dreschel

et al.

Preventive Veterinary Medicine, Journal Year: 2025, Volume and Issue: 239, P. 106520 - 106520

Published: March 30, 2025

Social determinants of health (SDOH) have an enormous impact on human and behavior, although their possible effects canine behavior received limited scientific attention. The goals this observational cohort study were to identify associations between household environments, zip code-level proxies for SDOH, explore longitudinal impacts behavior. We used existing dataset C-BARQ behavioral assessments from 3044 golden retrievers in the United States, including up eight years data per dog collected 2012 2023. analyzed using linear mixed effect models generalized estimating equations. found dogs single-dog homes had increased odds dog-directed fear (OR 1.44, 95 % CI 1.30-1.61) poorer trainability, particularly during early adulthood (F=14.32, p < 0.001). Sleeping owners' bed was associated with aggression towards strangers, a greater reduction trainability (F=20.71, 0.001) energy age (F=8.20, = 0.004). Dogs most densely populated neighborhoods showing strangers compared sparsely 0.78, 0.63-0.95) or moderately 0.73, 0.60-0.90). Together, our findings illustrate how conspecific relationships, interactions, home neighborhood environments affect show, first time, that characteristics ownership behaviors differential across lifespan. Future studies more diverse populations are needed provide further insights about SDOH welfare.

Language: Английский

The multiple roles of life stress in metabolic disorders DOI
Mika Kivimäki, Alessandro Bartolomucci, Ichiro Kawachi

et al.

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 19(1), P. 10 - 27

Published: Oct. 12, 2022

Language: Английский

Citations

130
Association of Race and Poverty Status With DNA Methylation–Based Age DOI Creative Commons

Botong Shen,

Nicolle A. Mode, Nicole Noren Hooten

et al.

JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(4), P. e236340 - e236340

Published: April 7, 2023

Importance The Dunedin Pace of Aging Calculated From the Epigenome (DunedinPACE) measure is a newly constructed DNA methylation (DNAm) biomarker associated with morbidity, mortality, and adverse childhood experiences in several cohorts European ancestry. However, there are few studies DunedinPACE among socioeconomically racially diverse longitudinal assessments. Objective To investigate association race poverty status scores middle-aged cohort African American White participants. Design, Setting, Participants This study used data from Healthy Neighborhoods Diversity Across Life Span (HANDLS) study. HANDLS population-based adults aged 30 to 64 years at baseline Baltimore, Maryland, follow-up approximately every 5 years. current was restricted 470 participants blood samples 2 time points: August 14, 2004, June 22, 2009 (visit 1), 23, 2009, September 12, 2017 2). Genome-wide DNAm assessed visit 1 (chronological age, 30-64 years) 2. Data were analyzed March 18, 2022, February 9, 2023. Main Outcomes Measures estimated for each participant visits. values scaled mean 1, interpretable reference rate year biological aging per chronological aging. Linear mixed-model regression analysis examine trajectories by race, sex, status. Results Among participants, (SD) age 48.7 (8.7) balanced sex (238 [50.6%] men 232 [49.4%] women), (237 [50.4%] 233 [49.6%] White), (236 [50.2%] living below level 234 [49.8%] above level). between visits 5.1 (1.5) Overall, score 1.07 (0.14), representing 7% faster pace than mixed-effects revealed an 2-way interaction (White household income level: β = 0.0665; 95% CI, 0.0298-0.1031; P &amp;lt; .001) significantly higher quadratic (age squared: −0.0113; −0.0212 −0.0013; .03) scores. Conclusions Relevance In this study, These findings suggest that varies as social determinants health. Consequently, measures accelerated should be based on representative samples.

Language: Английский

Citations

29
The impact of life stress on hallmarks of aging and accelerated senescence: Connections in sickness and in health DOI Creative Commons
Carey E. Lyons, Maria Razzoli, Alessandro Bartolomucci

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 153, P. 105359 - 105359

Published: Aug. 15, 2023

Language: Английский

Citations

26
Environmental and genetic predictors of human cardiovascular ageing DOI Creative Commons
Mit Shah, Marco Henrique de Almeida Inácio, Chang Lu

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 21, 2023

Cardiovascular ageing is a process that begins early in life and leads to progressive change structure decline function due accumulated damage across diverse cell types, tissues organs contributing multi-morbidity. Damaging biophysical, metabolic immunological factors exceed endogenous repair mechanisms resulting pro-fibrotic state, cellular senescence end-organ damage, however the genetic architecture of cardiovascular not known. Here we use machine learning approaches quantify age from image-derived traits vascular function, cardiac motion myocardial fibrosis, as well conduction electrocardiograms, 39,559 participants UK Biobank. found be significantly associated with common or rare variants genes regulating sarcomere homeostasis, immunomodulation, tissue responses biophysical stress. Ageing accelerated by cardiometabolic risk also identify prescribed medications are potential modifiers ageing. Through large-scale modelling multiple our results reveal insights into driving premature molecular targets attenuate age-related processes.

Language: Английский

Citations

24
The ASTCT-NMDP ACCESS Initiative: A Collaboration to Address and Sustain Equal Outcomes for All across the Hematopoietic Cell Transplantation and Cellular Therapy Ecosystem DOI Creative Commons
Jeffery J. Auletta, Brenda M. Sandmaier,

Erica Jensen

et al.

Transplantation and Cellular Therapy, Journal Year: 2022, Volume and Issue: 28(12), P. 802 - 809

Published: Sept. 30, 2022

The American Society for Transplantation and Cellular Therapy (ASTCT) the National Marrow Donor Program (NMDP) have formed ACCESS Initiative to address reduce barriers hematopoietic cell transplantation (HCT) cellular therapy (CT) in an effort ensure equal access outcomes all patients need. In addition physicians, initiative includes program administrators, health policy equity experts, service researchers, participants from commercial payer organizations, federal stakeholders. inaugural ASTCT-NMDP Workshop was held Washington, DC on July 28 29, 2022, wherein committee members met discuss define goals 3 focus areas: awareness, poverty, racial ethnic inequity. This position paper reviews mission, vision, structure of proceedings workshop provides initial roadmap group's efforts at reducing outcome disparities HCT/CT.

Language: Английский

Citations

32
To promote healthy aging, focus on the environment DOI
Daniel W. Belsky, Andrea Baccarelli

Nature Aging, Journal Year: 2023, Volume and Issue: 3(11), P. 1334 - 1344

Published: Nov. 9, 2023

Language: Английский

Citations

22
Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease DOI Creative Commons
Daniel E. Forman, George A. Kuchel, John C. Newman

et al.

Journal of the American College of Cardiology, Journal Year: 2023, Volume and Issue: 82(7), P. 631 - 647

Published: June 28, 2023

Language: Английский

Citations

20
Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals DOI Creative Commons
Anjali M. Byappanahalli, Nicole Noren Hooten,

Mya Vannoy

et al.

Immunity & Ageing, Journal Year: 2023, Volume and Issue: 20(1)

Published: Jan. 30, 2023

Frailty, a clinical syndrome commencing at midlife, is risk for morbidity and mortality. Little known about the factors that contribute to chronic inflammatory state associated with frailty. Extracellular vesicles (EVs) are small, membrane-bound released into circulation mediators of intercellular communication. We examined whether mitochondrial DNA (mtDNA) proteins in EVs may act as damage-associated molecular pattern (DAMP) molecules frailty.To address their mtDNA protein cargo altered frailty, were isolated from non-frail (n = 90) frail 87) middle-aged (45-55 years) participants Healthy Aging Neighborhoods Diversity across Life Span (HANDLS) study. EV concentration was highest White participants. levels significantly higher individuals compared individuals. The presence six (FGF-21, HGF, IL-12B, PD-L1, PRDX3, STAMBP) by frailty status, race, sex, poverty status. Notably, had EV-associated CD5, CD8A, CD244, CXCL1, CXCL6, CXCL11, LAP-TGF-beta-1 MCP-4 African American Frail living below uPA. CCL28 women CXCL1 men. Men LAP-TGF-beta-1, CXCL6 above poverty. There significant correlation between proteins.These data suggest within DAMP molecule Its association chemokines other proteins, phenotype. In addition, social determinant health, poverty, influences midlife.

Language: Английский

Citations

19
Living in poverty and accelerated biological aging: evidence from population-representative sample of U.S. adults DOI Creative Commons
Andrea Dalecká, Anna Bartošková Polcrová, Hynek Pikhart

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 13, 2024

Abstract Background Biological aging reflects a decline in the functions and integrity of human body that is closely related to chronological aging. A variety biomarkers have been found predict biological age. age higher than (biological acceleration) indicates an accelerated state risk premature morbidity mortality. This study investigated how socioeconomic disadvantages influence Methods The data from National Health Nutrition Examination Survey (NHANES) IV, including 10 nationally representative cross-sectional surveys between 1999-2018, were utilized. analytic sample consisted N = 48,348 individuals (20-84 years). We used total 11 for estimating Our main outcome was acceleration, indexed by PhenoAge acceleration (PAA) Klemera-Doubal (KDM-A). Poverty measured as ratio family income poverty thresholds defined U.S. Census Bureau, adjusted annually inflation size (5 categories). PAA KDM-A regressed on levels, age, their interaction, education, sex, race, collection wave. Sample weights make estimates adult population. Results results showed associated with (PAA: unstandardized coefficient B 1.38 p <.001, KDM: 0.96, .026 when comparing highest lowest level categories), above beyond other covariates. association U-shaped. Importantly, there interaction levels ( <.001), effect most pronounced middle-aged categories while it modest younger elderly groups. Conclusion In US population, we positively particularly among persons.

Language: Английский

Citations

8
A scoping review of geriatric emergency medicine research transparency in diversity, equity, and inclusion reporting DOI
Anita Chary, Michelle Suh, Edgardo Ordoñez

et al.

Journal of the American Geriatrics Society, Journal Year: 2024, Volume and Issue: 72(11), P. 3551 - 3566

Published: July 12, 2024

The intersection of ageism and racism is underexplored in geriatric emergency medicine (GEM) research.

Language: Английский

Citations

8