Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 239, P. 113938 - 113938
Published: May 3, 2024
Language: Английский
Biomarkers in Neuropsychiatry, Journal Year: 2023, Volume and Issue: 8, P. 100063 - 100063
Published: April 18, 2023
Alzheimer's disease (AD) is an age-related neurodegenerative and the leading cause of dementia worldwide. AD associated with several neuropathologic changes including progressive accumulation extracellular amyloid-β (Aβ) plaques, intracellular neurofibrillary tau tangles, neuroinflammation, cerebral small vessel neurodegeneration, many which are known to begin years before onset clinical symptoms. As such, there a growing interest in developing biomarkers that can be used detect these brains at-risk individuals facilitate earlier more accurate diagnosis. This may allow for intervention disease-modifying therapies slow progression irreversible neurodegeneration improve quality life. The current review seeks provide concise overview neuropathology genetics underlying AD, then summarize most promising clinically available experimental AD. These include structural neuroimaging, functional magnetic resonance imaging (fMRI), positron emission tomography (PET), cerebrospinal fluid (CSF), blood-based assays. Multiple potential uses described, screening populations disease, aiding differential diagnosis mild cognitive impairment (MCI), monitoring impact lifestyle modifying therapies, identification treatment neuropsychiatric symptoms dementia, planning end life care. Finally, additional areas future research discussed, replication biomarker studies diverse patient cohorts, characterization real-world psychological impacts testing, as well novel currently under investigation.
Language: Английский
Citations
15
Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: April 27, 2023
Being isolated from the peripheral system by blood–brain barrier, brain has long been considered a completely impervious tissue. However, recent findings show that gut microbiome (GM) influences gastrointestinal and disorders such as Alzheimer’s disease (AD). Despite several hypotheses, neuroinflammation, tau hyperphosphorylation, amyloid plaques, neurofibrillary tangles, oxidative stress, being proposed to explain origin progression of AD, pathogenesis remains incompletely understood. Epigenetic, molecular, pathological studies suggest GM AD development have endeavored find predictive, sensitive, non-invasive, accurate biomarkers for early diagnosis monitoring progression. Given growing interest in involvement current research endeavors identify prospective both preclinical clinical diagnoses, well targeted therapy techniques. Here, we discuss most on changes microbiome-based biomarkers, diagnostic uses, approaches. Furthermore, addressed herbal components, which could provide new venue research.
Language: Английский
Citations
15
Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15
Published: March 23, 2023
Alzheimer's disease (AD) is a common neurodegenerative disease. The concealment of the difficulty its prevention and treatment. Previous studies have shown that mitophagy crucial to development AD. However, there lack research on identification clinical significance mitophagy-related genes in Therefore, purpose this study was identify with diagnostic potential for AD establish model
Language: Английский
Citations
13
TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 172, P. 117546 - 117546
Published: Jan. 17, 2024
Language: Английский
Citations
5
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 239, P. 113938 - 113938
Published: May 3, 2024
Language: Английский
Citations
5