Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(5), P. 535 - 535
Published: April 29, 2025
Peach,
apricot,
chokeberry,
blueberry,
cranberry,
raspberry,
and
wild
strawberry
fruits
were
used
to
create
a
polyphenolic
preparation
(PP)
after
enzyme-assisted
extraction,
ultrafiltration,
concentration.
The
composition
of
PP
was
determined
using
LC-MS.
Gelatin
jellies
produced
with
PP,
as
well
liquid
“digested”
in
an
vitro
model.
entrapment
the
gelatin
matrix
delayed
release
total
polyphenolics,
flavonoids,
flavanols,
condensed
tannins,
anthocyanins
(predominantly
during
“small
intestinal”
phase).
entrapped
jelly
more
effectively
(p
<
0.05)
decreased
activity
acetylcholinesterase,
butyrylcholinesterase,
cyclooxygenase-2
catalase
(during
However,
no
significant
effects
on
superoxide
dismutase,
glutathione
peroxidase,
reductase
activities
observed.
FRAP,
CUPRAC,
HORAC,
oxidation
linoleic
acid,
ABTS-reducing
higher
“intestinal”
phase;
however,
DPPH
test
β-carotene
bleaching
tests
did
not
confirm
these
results.
presented
findings
may
be
useful
for
designing
nutraceuticals
programmed
bioactive
compounds
digestion.
Archiv der Pharmazie,
Journal Year:
2025,
Volume and Issue:
358(1)
Published: Jan. 1, 2025
Abstract
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
cognitive
decline
and
memory
impairments
considered
the
most
prevalent
form
of
dementia.
Among
contributing
factors
to
AD
lies
hyperphosphorylation
microtubule‐associated
protein
tau.
Phosphorylated
tau
reduces
its
affinity
for
microtubules
triggers
other
posttranslational
modifications
that
result
in
aggregation
assembly
into
filaments.
These
structures
progressively
accumulate
within
neurons
leading
neurodegeneration.
While
current
medications
often
involve
undesirable
side
effects,
exploration
natural
products
as
potential
therapeutic
alternative
has
gained
considerable
attention.
Numerous
compounds
have
shown
capacity
reducing
pathology
through
different
mechanisms,
such
inhibiting
kinases
reduce
hyperphosphorylation,
enhancing
phosphatase
activity,
blocking
fibril
formation.
Since
hyperphosphorylation‐induced
pivotal
onset,
this
review
aims
elucidate
modulating
crucial
molecular
mechanism.
Journal of Alzheimer s Disease,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
that
primarily
affects
the
elderly,
leading
to
severe
cognitive
decline
and
loss
of
autonomy.
The
accumulation
amyloid-β
peptides
tau
proteins
in
brain
considered
central
pathogenic
mechanism,
which
results
neuronal
dysfunction
cell
death.
Various
metabolic
disruptions,
such
as
chronic
oxidative
stress
inflammatory
processes,
further
exacerbate
progression
AD.
This
review,
based
on
literature
from
PubMed,
SciELO,
MDPI,
ScienceDirect,
evaluates
role
bioactive
compounds
dietary
patterns,
specifically
Mediterranean
MIND
diets,
mitigating
These
rich
vitamins,
flavonoids,
carotenoids,
omega-3
fatty
acids,
have
shown
potential
reducing
damage
inflammation
brain,
offering
neuroprotective
benefits.
findings
suggest
vitamin
E
isomers
polyphenols
may
delay
decline,
presenting
promising
avenue
for
future
interventions
aimed
at
optimizing
consumption
these
prevent
or
slow
onset
Further
research
needed
determine
optimal
doses
combinations
maximize
their
protective
effects.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(5), P. 535 - 535
Published: April 29, 2025
Peach,
apricot,
chokeberry,
blueberry,
cranberry,
raspberry,
and
wild
strawberry
fruits
were
used
to
create
a
polyphenolic
preparation
(PP)
after
enzyme-assisted
extraction,
ultrafiltration,
concentration.
The
composition
of
PP
was
determined
using
LC-MS.
Gelatin
jellies
produced
with
PP,
as
well
liquid
“digested”
in
an
vitro
model.
entrapment
the
gelatin
matrix
delayed
release
total
polyphenolics,
flavonoids,
flavanols,
condensed
tannins,
anthocyanins
(predominantly
during
“small
intestinal”
phase).
entrapped
jelly
more
effectively
(p
<
0.05)
decreased
activity
acetylcholinesterase,
butyrylcholinesterase,
cyclooxygenase-2
catalase
(during
However,
no
significant
effects
on
superoxide
dismutase,
glutathione
peroxidase,
reductase
activities
observed.
FRAP,
CUPRAC,
HORAC,
oxidation
linoleic
acid,
ABTS-reducing
higher
“intestinal”
phase;
however,
DPPH
test
β-carotene
bleaching
tests
did
not
confirm
these
results.
presented
findings
may
be
useful
for
designing
nutraceuticals
programmed
bioactive
compounds
digestion.
