International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114281 - 114281
Published: Feb. 12, 2025
Language: Английский
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(19)
Published: Feb. 22, 2023
Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to enhance neurogenesis angiogenesis have appeared be promising direction. However, the current treatments failed coordinate simultaneously, leading an increased disability rate caused by DWs. Herein, whole-course-repair system introduced hydrogel concurrently achieve mutually supportive cycle of neurogenesis-angiogenesis under favorable immune-microenvironment. This can first one-step packaged syringe for later situ local injections cover wounds long-termly accelerated healing via synergistic effect magnesium ions (Mg2+ ) engineered small extracellular vesicles (sEVs). The self-healing bio-adhesive properties make it ideal physical barrier At inflammation stage, formulation recruit bone marrow-derived mesenchymal stem cells sites stimulate them toward neurogenic differentiation, while providing immune microenvironment macrophage reprogramming. proliferation stage repair, robust occurs newly differentiated neural released Mg2+ , allowing regenerative take place at site. provides novel platform combined DW therapy.
Language: Английский
Citations
209
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Jan. 1, 2024
Abstract Combining existing drug therapy is essential in developing new therapeutic agents disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established treating extensive human diseases. Attributed to synergistic effects by targeting various pathways advantages, such as reduced administration dose, decreased toxicity, alleviated resistance, combinatorial treatment now being pursued delivering combat major clinical illnesses, cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders neurodegenerative Combinatorial involves combining or co-delivering two more for a specific disease. Nanoparticle (NP)-mediated delivery systems, i.e., liposomal NPs, polymeric NPs nanocrystals, are great interest wide range due targeted delivery, extended release, higher stability avoid rapid clearance at infected areas. This review summarizes targets diseases, clinically approved combinations the development multifunctional emphasizes strategies based on severe Ultimately, we discuss challenging NP-codelivery translation provide potential approaches address limitations. offers comprehensive overview recent cutting-edge NP-mediated combination
Language: Английский
Citations
125
Hippocampus, Journal Year: 2023, Volume and Issue: 33(4), P. 307 - 321
Published: Feb. 7, 2023
Abstract Alzheimer's disease (AD) is the most common form of age‐related dementia, characterized by progressive memory loss and cognitive disturbances. The hippocampus, where adult hippocampal neurogenesis (AHN), a relatively novel brain plasticity that refers to birth new neurons, occurs, one first regions be affected in AD patients. Recent studies showed AHN persists throughout life humans, but it drops sharply Next questions consider would whether impairment contributing factor learning restoring could ameliorate or delay dysfunction. Here, we outline discuss current knowledge about state patients, as potentially relevant mechanism underlying deficits AD, therapeutic potential activating mechanisms AD.
Language: Английский
Citations
37
Clinical Nutrition, Journal Year: 2023, Volume and Issue: 43(1), P. 1 - 10
Published: Nov. 15, 2023
Language: Английский
Citations
25
Cell Reports, Journal Year: 2023, Volume and Issue: 42(9), P. 113022 - 113022
Published: Aug. 22, 2023
Cognitive impairment has been associated with an age-related decline in adult hippocampal neurogenesis (AHN). The molecular basis of declining the aging hippocampus remains to be elucidated. Here, we show that pleiotrophin (PTN) expression is decreased neural stem and progenitor cells (NSPCs). Mice lacking PTN exhibit impaired AHN accompanied by poor learning memory. Mechanistically, find engages protein tyrosine phosphatase receptor type Z1 (PTPRZ1) promote NSPC proliferation differentiation activating AKT signaling. overexpression or pharmacological activation signaling mice restores alleviates relevant memory deficits. Importantly, also improves senescence-accelerated mouse prone 8 (SAMP8) mice. We further confirm required for enriched environment-induced increases AHN. These results corroborate significance reveal a possible therapeutic intervention targeting PTN.
Language: Английский
Citations
24
Neurosciences, Journal Year: 2025, Volume and Issue: 30(1), P. 5 - 19
Published: Jan. 1, 2025
The hippocampus, noted as (HC), plays a crucial role in the processes of learning, memory formation, and spatial navigation. Recent research reveals that this brain region can undergo structural functional changes due to environmental exposures, including stress, noise pollution, sleep deprivation, microgravity. This review synthesizes findings from animal human studies, emphasizing HC's plasticity response these factors. It examines volume, architecture, neurogenesis, synaptic plasticity, gene expression highlights critical periods vulnerability influences impacting cognition behavior. also investigates underlying mechanisms such glucocorticoid signaling, epigenetic alterations, neural circuit adaptations. Understanding how HC reacts various exposures is vital for developing strategies enhance cognitive resilience mitigate negative effects on region. Further needed identify protective risk factors create effective interventions.
Language: Английский
Citations
1
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0313486 - e0313486
Published: Jan. 16, 2025
1-Methylxanthine (1-MX) is the major metabolite of caffeine and paraxanthine might contribute to their activity. 1-MX an adenosine receptor antagonist increases release survivability neurotransmitters; however, no study has addressed potential physiological effects ingestion. The aim this was compare effect on memory related biomarkers in rats compared control. Memory (escape latency Morris water maze test), neurotransmitters (acetylcholine, dopamine, gamma-amino butyric acid (GABA)), neurochemicals (BDNF, catalase, glutathione, Amyloid Beta cyclic GMP) were analyzed from whole brain samples young (8-weeks-old) aged (16-months-old) following 12 days supplementation (100 mg/d HED [UPLEVEL®, Ingenious Ingredients L.P., Lewisville, TX, USA]) via oral gavage. reduced escape by 39% animals 27% controls (both p<0.001). Additionally, increased levels acetylcholine, GABA, GMP (all Furthermore, led amyloid beta higher BDNF glutathione concentrations (p<0.001). Collectively, our findings suggest that may have cognitive-enhancing neuroprotective properties.
Language: Английский
Citations
1
Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 24, 2025
Enriched environment (EE), as a non-pharmacological intervention, has garnered considerable attention for its potential to ameliorate neurodegenerative diseases (NDs). This review delineated the impact of EE on biological functions associated with NDs, emphasizing role in enhancing neural plasticity, reducing inflammation, and bolstering cognitive performance. We discussed molecular underpinnings effects EE, including modulation key signaling pathways such extracellular regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinases (MAPK), AMPK/SIRT1, which were implicated neuroprotection synaptic plasticity. Additionally, we scrutinized influence epigenetic modifications autophagy, processes pivotal ND pathogenesis. Animal models, encompassing both rodents larger animals, offer insights into disease-modifying underscoring complementary approach pharmacological interventions. In summary, emerges promising strategy augment function decelerate progression NDs.
Language: Английский
Citations
1
Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 83, P. 101791 - 101791
Published: Nov. 17, 2022
Language: Английский
Citations
30
Marine Drugs, Journal Year: 2023, Volume and Issue: 21(12), P. 643 - 643
Published: Dec. 16, 2023
Decreased adult neurogenesis, or the gradual depletion of neural stem cells in neurogenic niches, is considered a hallmark brain aging. This review provides comprehensive overview intricate relationship between aging, and potential neuroregenerative properties astaxanthin, carotenoid principally extracted from microalga Haematococcus pluvialis. The unique chemical structure astaxanthin enables it to cross blood–brain barrier easily reach brain, where may positively influence neurogenesis. Astaxanthin can affect molecular pathways involved homeostasis, through activation FOXO3-related genetic pathways, growth, regeneration neurons, enhancing cell proliferation potency progenitor cells. Furthermore, appears modulate neuroinflammation by suppressing NF-κB pathway, reducing production pro-inflammatory cytokines, limiting associated with aging chronic microglial activation. By modulating these along its potent antioxidant properties, contribute restoration healthy microenvironment, thereby preserving activity niches during both normal pathological
Language: Английский
Citations
21