Mitigating cellular aging and enhancing cognitive functionality: visual arts-mediated Cognitive Activation Therapy in neurocognitive disorders DOI Creative Commons
Manuela Campisi, Luana Cannella, Dilek Celik

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: March 8, 2024

The growing phenomenon of population aging is redefining demographic dynamics, intensifying age-related conditions, especially dementia, projected to triple by 2050 with an enormous global economic burden. This study investigates visual arts-mediated Cognitive Activation Therapy (CAT) as a non-pharmacological CAT intervention targets both biological [leukocyte telomere length (LTL), DNA methylation age (DNAmAge)] and cognitive functionality. Aligning broader trend integrating approaches into dementia care. longitudinal involved 20 patients mild moderate neurocognitive disorders. functional assessments, markers -i.e., LTL DNAmAge- were analyzed before after intervention. Change in was positively correlated days treatment ( p =0.0518). significantly elongated =0.0269), men =0.0142), correlating younger =0.0357), higher education =0.0008). DNAmAge remained instead stable post-treatment. improvements observed for Copy complex geometric figure, Progressive Silhouettes, Position Discrimination, Communication Activities Daily Living—Second edition, Direct Functional Status < 0.0001) Object decision =0.0594), but no correlations found between gains. Visual effectively mitigates cellular aging, men, elongating LTL. These findings underscore the potential interventions enhancing status general well-being Further research larger longer-term studies essential validation.

Language: Английский

Senescent Slowing DOI

Steven C. Hertler,

Aurelio José Figueredo, Mateo Peñaherrera‐Aguirre

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Myriad Forms of Memory DOI

Steven C. Hertler,

Aurelio José Figueredo, Mateo Peñaherrera‐Aguirre

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Aging Brains and Bodies: Evidence and Evolutionary Context DOI

Steven C. Hertler,

Aurelio José Figueredo, Mateo Peñaherrera‐Aguirre

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 8-Week Pilot Study of Tuna-Byproduct-Derived Novel Supplements for Managing Cellular Senescence and Cognitive Decline in Perimenopausal and Postmenopausal Women DOI Creative Commons
Jintanaporn Wattanathorn, Wipawee Thukham-mee, Terdthai Tong-un

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 520 - 520

Published: April 27, 2025

Due to the lack of clinical data, we aimed assess anti-cellular senescence and cognition-enhancing effects mechanisms novel tuna-byproduct-derived supplements. An 8-week, three-arm, randomized, double-blind, placebo-controlled parallel study was performed. A total 60 female perimenopausal postmenopausal women (45–60 years old) were randomly assigned placebo, low (2600 mg/day), high (6000 mg/day) doses supplement. The N100 P300 brain waves, working memory, serum levels MDA, SOD, CAT, GPx TNF-α, IL-6, eNOS, AChE, MAO, GABA-T, SIRT1, density Lactobacillus Bifidobacterium spp. in feces assessed before consumption every 4 weeks throughout period. telomere length phenolic compound DHA at end study. dose increased amplitude, length, whereas improved amplitudes N00 P300, latency, memory; suppressed GABA-T; GPx, IL-6 serum, further exhibiting an increase DHA. Therefore, supplement could be a potential remedy for managing cellular cognitive decline women; however, studies with larger sample sizes are required.

Language: Английский

Citations

0
Reverse causal relationship between periodontitis and shortened telomere length: Bidirectional two-sample Mendelian random analysis DOI Creative Commons

Jiaxin Hu,

Jukun Song,

Zhu Chen

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 19, 2022

Observational studies have demonstrated a link between shortened telomere lengths(TL) and chronic periodontitis. However, whether the TL is cause or result of periodontitis unknown.Therefore, our objective was to investigate bidirectional causal relationship using two-sample Mendel randomized (MR) study.A MR analysis publicly available genome-wide association study (GWAS) data used. As primary analysis, inverse variance weighting (IVW) employed. To identify pleiotropy, we used leave-one-out MR-Egger, Weighted median, Simple mode, pleiotropy residual sum outlier (MR-PRESSO).In reverse results, genetic prediction short causally associated with higher risk (IVW: odds ratio [OR]: 1.0601, 95% confidence interval [CI]: 1.0213 1.1002; P =0.0021) other complementary methods. In forward shown no significant effect on p = 0.7242), consistent results for remaining MR. No detected in sensitivity (all P>0.05).Our showed relationship, shorten being linked periodontitis, rather than that TL. Future research needed cell senescence disease.

Language: Английский

Citations

17
The Executive Functioning of the Chief Executive DOI

Steven C. Hertler,

Aurelio José Figueredo, Mateo Peñaherrera‐Aguirre

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Arousal, Attention, and Executive Functioning DOI

Steven C. Hertler,

Aurelio José Figueredo, Mateo Peñaherrera‐Aguirre

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Toward a Consolidated Understanding of Intelligence DOI

Steven C. Hertler,

Aurelio José Figueredo, Mateo Peñaherrera‐Aguirre

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Shorter Telomere Length in Individuals with Neurocognitive Disorder and APOE ε4 Genotype DOI Open Access

Paola Mejía-Ortiz,

Alma Delia Genis‐Mendoza,

Ronald Villanueva

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4577 - 4577

Published: May 10, 2025

Neurocognitive disorders (NCD) are neurodegenerative diseases characterized by decline or loss of cognitive functions. Aging and the APOE genotype have been identified as major risk factors. Telomere length (TL) has proposed a biomarker aging, with shorter TL associated decline. This study investigated relationship between in individuals impairments (CIs). A total 170 participants aged >55 years were included. Cognitive function was assessed using MMSE MoCA tests. Relative telomere quantification determined real-time PCR. significant association observed an increased CI (p < 0.001). Although ε4 is known genetic factor, its less clear this population, considerable proportion carriers did not present impairment 0.05). However, tended to than those non-cognitive (NCI-SMC). Furthermore, fewer education strongly correlated higher 0.0001). Overall, both telomeres lower educational levels exhibited highest CI. may contribute shortening.

Language: Английский

Citations

0
Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression DOI Creative Commons
Ryan Rampersaud, Gwyneth W. Y. Wu, Victor I. Reus

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: June 23, 2023

Abstract Telomere length (TL) is a marker of biological aging, and shorter telomeres have been associated with several medical psychiatric disorders, including cardiometabolic dysregulation Major Depressive Disorder (MDD). In addition, studies shown TL to be poorer response certain psychotropic medications, our previous work suggested higher telomerase activity (TA) predicts Selective Serotonin Reuptake Inhibitor (SSRI) treatment. Using new group unmedicated medically healthy individuals MDD (n = 48), we sought replicate prior findings demonstrating that peripheral blood mononuclear cell (PBMC) TA predict SSRI treatment identify associations between stress mediators risk indices. Our results demonstrate longer pre-treatment was better ( β .407 p .007). Additionally, observed had negative relationship allostatic load − .320 .017) score (β .300 .025). suggest PBMC reflects, in part, the cumulative effects physiological cardiovascular may biomarker for predicting response.

Language: Английский

Citations

9