Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metanálisis DOI Creative Commons
Gustavo Díaz, Luís García Rairán, Valentina Corredor

et al.

Revista Española de Nutrición Humana y Dietética, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 3, 2023

Introducción: el declive cognitivo es un marcador de la aparición y avance enfermedad Alzheimer (EA). Actualmente, modificación factores riesgo, como nutrición, son promisorios para tratamiento EA. El objetivo fue Identificar efecto suplementación vitaminas del complejo B sobre en pacientes con daño o Materiales métodos: Revisión sistemática metaanálisis literatura cinco buscadores (PROSPERO CRD42021247743). Se incluyeron experimentos controlados, adultos 60 más años, medición estado (ADAS-Cog, Clinical dementia ratin-CDR y/o Mini Mental State Examination-MMSE) uso suplementos manera individual combinada otras fármacos. La evaluación calidad se hizo herramienta RoB-2. selección, extracción por tres investigadores independiente. empleo diferencia media modelos efectos aleatorios. Resultados: búsqueda arrojo 247 referencias finalmente 12 metaanálisis. No encontraron sesgos publicación. los estudios adecuada. suplemento vitamina no mostró medido ADAS-Cog (DM 0.01 IC95% -0.7 a 0.72), CDR –0.06 -0.48 0.36) MMSE 0.3 -0.01 0.61). Conclusiones: invariable ante Enfermedad Alzheimer. Futuras investigaciones deben enfocarse hacia estrategias multi intervención. Palabras claves: Alzheimer; cognitivo; B; Financiación: Los autores/as declaran que ha existido financiación realizar este estudio. Registro: PROSPERO CRD42021247743

Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI) DOI Creative Commons
Jie Liu,

Heleen van Beusekom,

Xian‐Le Bu

et al.

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2023, Volume and Issue: 1(2), P. 84 - 98

Published: Sept. 21, 2023

Abstract The global trend toward aging populations has resulted in an increase the occurrence of Alzheimer's disease (AD) and associated socioeconomic burdens. Abnormal metabolism amyloid‐β (Aβ) been proposed as a significant pathomechanism AD, supported by results recent clinical trials using anti‐Aβ antibodies. Nonetheless, cognitive benefits current treatments are limited. etiology AD is multifactorial, encompassing Aβ tau accumulation, neuroinflammation, demyelination, vascular dysfunction, comorbidities, which collectively lead to widespread neurodegeneration brain impairment. Hence, solely removing from may be insufficient combat preserve cognition. To attain effective treatment for it necessary (1) conduct extensive research on various mechanisms that cause neurodegeneration, including advances neuroimaging techniques earlier detection more precise characterization molecular events at scales ranging cellular full system level; (2) identify neuroprotective intervention targets against different mechanisms; (3) discover novel optimal combinations strategies maintain function patients. Disease Neuroprotection Research Initiative's objective facilitate coordinated, multidisciplinary efforts develop systemic AD. aim achieve mitigation spectrum pathological processes underlying with goal halting or even reversing decline.

Language: Английский

Citations

10
Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer’s disease DOI Creative Commons
Takuya Seike, Che‐Hong Chen, Daria Mochly‐Rosen

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Aug. 24, 2023

Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that plays a central role alcohol and aldehyde metabolism. A common ALDH2 polymorphism East Asians descent (called ALDH2*2 or E504K missense variant, SNP ID: rs671), present approximately 8% of world’s population, has been associated with variety diseases. Recent meta-analyses support relationship between this Alzheimer’s disease (AD). And AD-like pathology observed –/– null mice overexpressing transgenic indicate deficiency important pathogenesis AD. Recently, worldwide increase consumption drawn attention to heavy Of potential clinical significance, chronic administration ALDH2*2/*2 knock-in exacerbates symptoms. Therefore, likely play onset progression Here, we review data on polymorphism, alcohol, AD, summarize what currently known about inactivating mutation, ALDH2*2,

Language: Английский

Citations

9
Metabolic Reprogramming toward Aerobic Glycolysis and the Gut Microbiota Involved in the Brain Amyloid Pathology DOI Creative Commons
Toshiyuki Murai, Satoru Matsuda

Biology, Journal Year: 2023, Volume and Issue: 12(8), P. 1081 - 1081

Published: Aug. 3, 2023

Alzheimer’s disease (AD) is characterized by the formation of senile plaques consisting fibrillated amyloid-β (Aβ), dystrophic neurites, and neurofibrillary tangles tau. The oligomers/fibrillar Aβ damages neurons or initiates an intracellular signaling cascade for neuronal cell death leading to toxicity. a 4 kDa molecular weight peptide originating from C-terminal region amyloid precursor protein via proteolytic cleavage. Apart typical AD hallmarks, certain deficits in metabolic alterations have been identified. This study describes emerging features aspect reprogramming main pathway carbohydrate metabolism human brain. Particularly, patients with favor glycolysis despite normal mitochondrial function indicating Warburg-like effect. In addition, dietary patterns are well known their properties preventing AD. Among those, ketogenic diet may substantially improve symptoms An effective therapeutic method treatment, mitigation, prevention has not yet established. Therefore, researchers pursue development establishment novel therapies suppressing elucidation underlying protective mechanisms against neurodegeneration aiming therapy near future.

Language: Английский

Citations

6
Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention DOI Creative Commons
Qiuyi Lu,

Anqi Yu,

Juncai Pu

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: May 23, 2024

Post-stroke cognitive impairment (PSCI) is a major stroke consequence that has severe impact on patients’ quality of life and survival rate. For this reason, it especially crucial to identify intervene early in high-risk groups during the acute phase stroke. Currently, there are no reliable efficient techniques for diagnosis, appropriate evaluation, or prognostication PSCI. Instead, plenty biomarkers patients have progressively been linked recent years. High-throughput omics generate large amounts data process high used screen PSCI order investigate molecular mechanisms disease. These include metabolomics, which explores dynamic changes organism, gut microbiomics, studies host–microbe interactions, genomics, elucidates deeper disease mechanisms, transcriptomics proteomics, describe gene expression regulation. We looked through electronic databases like PubMed, Cochrane Library, Embase, Web Science, common each find might be connected pathophysiology As all, we found 34 studies: 14 field 5 4 transcriptomics, 7 proteomics. discovered neuroinflammation, oxidative stress, atherosclerosis may primary causes development, metabolomics play role In study, summarized existing issues across technologies discuss latest discoveries context omics, with goal investigating post-stroke impairment. also potential therapeutic utility platforms intervention promote area’s advancement towards precision treatment.

Language: Английский

Citations

1
Impact of Nut Consumption on Cognition across the Lifespan DOI Creative Commons
Stephanie Nishi, Aleix Sala‐Vila, Jordi Júlvez

et al.

Published: Aug. 8, 2024

<p>Cognitive health is a life-long concern affected by modifiable risk factors, including lifestyle choices, such as dietary intake, with serious implications for quality of life, morbidity, and mortality worldwide. In addition, nuts are nutrient-dense food that contain number potentially neuroprotective components, monounsaturated polyunsaturated fatty acids, fiber, B-vitamins, non-sodium minerals, highly bioactive polyphenols. However, increased nut consumption relates to lower cardiovascular burden factors shared neurodegenerative disorders, which why have been hypothesized be beneficial brain health. The present narrative review discusses up-to-date epidemiological, clinical trial, mechanistic evidence the effect exposure on cognitive performance. While limited inconclusive, available suggests possible role in maintenance prevention decline individuals across lifespan, particularly older adults those at higher risk. Walnuts, rich source plant-based omega-3 acid alpha-linolenic acid, type most promising Given definitive date, especially regarding biomarkers hard outcomes, future studies needed better elucidate impact health, well management dementia, Alzheimer disease.</p>

Language: Английский

Citations

1
Aggregation-induced emission-based covalent-organic framework fluorescent probes for clinical detection of aluminum and daily prevention of Alzheimerʼs disease by naked-eye DOI
Yun Zhao,

Enpeng Xi,

Ziwei Wang

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Language: Английский

Citations

1
Impact of Nut Consumption on Cognition across the Lifespan DOI Creative Commons
Stephanie Nishi, Aleix Sala‐Vila, Jordi Júlvez

et al.

Published: Aug. 8, 2024

<p>Cognitive health is a life-long concern affected by modifiable risk factors, including lifestyle choices, such as dietary intake, with serious implications for quality of life, morbidity, and mortality worldwide. In addition, nuts are nutrient-dense food that contain number potentially neuroprotective components, monounsaturated polyunsaturated fatty acids, fiber, B-vitamins, non-sodium minerals, highly bioactive polyphenols. However, increased nut consumption relates to lower cardiovascular burden factors shared neurodegenerative disorders, which why have been hypothesized be beneficial brain health. The present narrative review discusses up-to-date epidemiological, clinical trial, mechanistic evidence the effect exposure on cognitive performance. While limited inconclusive, available suggests possible role in maintenance prevention decline individuals across lifespan, particularly older adults those at higher risk. Walnuts, rich source plant-based omega-3 acid alpha-linolenic acid, type most promising Given definitive date, especially regarding biomarkers hard outcomes, future studies needed better elucidate impact health, well management dementia, Alzheimer disease.</p>

Language: Английский

Citations

0
Research Progress on the Correlation between Alzheimer’s Disease and Intestinal Microbiota DOI

璐璐 张

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(08), P. 780 - 786

Published: Jan. 1, 2024

Language: Английский

Citations

0
Alzheimer’s disease. Current evidence on the preventive role of nutrition DOI Creative Commons
Ana María Lorenzo-Mora, María Del Carmen Lozano-Estevan,

Yalda Ghazi

et al.

Nutrición Hospitalaria, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

Introduction: in the last decades, a significant increase incidence of Alzheimer's disease (AD) has been observed. Currently, there are no effective pharmacological treatments available, which makes preventive measures particularly important. Objective: to analyze available scientific evidence on nutritional and dietary factors their association with AD prevention. Methods: review related prevention was conducted. Results: several components have positively associated prevention, including intake complex carbohydrates, fiber, omega-3, plant-based proteins, vitamins (folates, choline, vitamin D, C, B6 B9), zinc, some bioactive compounds such as flavonols probiotics. Following Mediterranean, Dietary Approaches Stop Hypertension (DASH) y Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets lower risk developing disease. Conclusion: nutrition may protective role against AD, although further studies needed this regard.Introducción: en las últimas décadas, se ha observado un incremento significativo la incidencia de enfermedad Alzheimer (EA). En actualidad, dispone tratamientos farmacológicos efectivos, lo que hace medidas preventivas sean particularmente importantes. Objetivo: analizar evidencia científica disponible sobre factores nutricionales dietéticos su asociación con prevención EA. Métodos: llevó cabo una revisión literatura relacionados Resultados: diversos componentes dieta han asociado positivamente Estos incluyen hidratos carbono complejos, fibra, proteínas origen vegetal, vitaminas (folatos, colina, vitamina zinc algunos compuestos bioactivos como los flavonoles, probióticos. El seguimiento dietas mediterránea, menor riesgo desarrollar enfermedad. Conclusión: nutrición podría tener papel protector frente EA, aunque requieren más estudios al respecto.

Citations

1
Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metanálisis DOI Creative Commons
Gustavo Díaz, Luís García Rairán, Valentina Corredor

et al.

Revista Española de Nutrición Humana y Dietética, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 3, 2023

Introducción: el declive cognitivo es un marcador de la aparición y avance enfermedad Alzheimer (EA). Actualmente, modificación factores riesgo, como nutrición, son promisorios para tratamiento EA. El objetivo fue Identificar efecto suplementación vitaminas del complejo B sobre en pacientes con daño o Materiales métodos: Revisión sistemática metaanálisis literatura cinco buscadores (PROSPERO CRD42021247743). Se incluyeron experimentos controlados, adultos 60 más años, medición estado (ADAS-Cog, Clinical dementia ratin-CDR y/o Mini Mental State Examination-MMSE) uso suplementos manera individual combinada otras fármacos. La evaluación calidad se hizo herramienta RoB-2. selección, extracción por tres investigadores independiente. empleo diferencia media modelos efectos aleatorios. Resultados: búsqueda arrojo 247 referencias finalmente 12 metaanálisis. No encontraron sesgos publicación. los estudios adecuada. suplemento vitamina no mostró medido ADAS-Cog (DM 0.01 IC95% -0.7 a 0.72), CDR –0.06 -0.48 0.36) MMSE 0.3 -0.01 0.61). Conclusiones: invariable ante Enfermedad Alzheimer. Futuras investigaciones deben enfocarse hacia estrategias multi intervención. Palabras claves: Alzheimer; cognitivo; B; Financiación: Los autores/as declaran que ha existido financiación realizar este estudio. Registro: PROSPERO CRD42021247743

Citations

0