Redox Biology, Journal Year: 2024, Volume and Issue: 79, P. 103473 - 103473
Published: Dec. 19, 2024
Language: Английский
Annals of Neurology, Journal Year: 2023, Volume and Issue: 94(6), P. 1048 - 1066
Published: Aug. 22, 2023
Because the role of white matter (WM) degenerating microglia (DM) in remyelination failure is unclear, we sought to define core features this novel population aging human microglia.
Language: Английский
Citations
29
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102278 - 102278
Published: March 19, 2024
Vascular dementia (VaD) is the second most common type of dementia. VaD synonymous with ageing, and its symptoms place a significant burden on health wellbeing older people. Despite identification substantial number risk factors for VaD, pathological mechanisms underpinning this disease remain to be fully elucidated. Consequently, biogerontological imperative exists highlight modifiable lifestyle which can mitigate against developing VaD. This review will critically examine some have been revealed modulate risk. The survey commences by providing an overview putative are associated pathobiology Next, influence examined. Finally, emerging treatment avenues including epigenetics, gut microbiome, pro-longevity pharmaceuticals discussed. By drawing key evidence together, it our hope that used inform future experimental investigations in field.
Language: Английский
Citations
15
CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)
Published: Feb. 1, 2025
ABSTRACT Background Vascular dementia (VaD) includes a group of brain disorders that are characterized by cerebrovascular pathology.Neuroinflammation, disruption the blood–brain barrier (BBB) permeability, white matter lesions, and neuronal loss all significant pathological manifestations VaD play key role in disease progression. Necroptosis, also known asprogrammed necrosis, is mode programmed cell death distinct from apoptosis closely associated with ischemic injury neurodegenerative diseases. Recent studies have shown necroptosis exacerbates BBB destruction, activates neuroinflammation, promotes loss, severely affects prognosis. Results Conclusions In this review, we outline roles its molecular mechanisms process VaD, particular focus on modulating neuroinflammation exacerbating permeability elaborate regulatory centrally involved cells mediated tumor necrosis factor‐α VaD. We analyze possibility specific strategy targeting would help inhibit destruction With necroptosis, study delved into impact changes prognosis to provide new treatment ideas.
Language: Английский
Citations
1
Biochemical and Biophysical Research Communications, Journal Year: 2023, Volume and Issue: 671, P. 246 - 254
Published: June 3, 2023
Language: Английский
Citations
17
Neurochemical Research, Journal Year: 2023, Volume and Issue: 48(10), P. 3113 - 3128
Published: June 20, 2023
Language: Английский
Citations
17
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Feb. 8, 2024
Vascular dementia (VD) is a prevalent cognitive disorder among the elderly. Its pathological mechanism encompasses neuronal damage, synaptic dysfunction, vascular abnormalities, neuroinflammation, and oxidative stress, others. In recent years, extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have garnered significant attention as an emerging therapeutic strategy. Current research indicates that MSC-derived (MSC-EVs) play pivotal role in both diagnosis treatment of VD. Thus, this article delves into advancements MSC-EVs VD, discussing mechanisms by which EVs influence pathophysiological processes These form theoretical foundation for their neuroprotective effect VD treatment. Additionally, highlights potential applications diagnosis. conclusion, present promising innovative strategy With rigorous ongoing innovation, concept can transition practical clinical treatment, providing more effective options patients.
Language: Английский
Citations
5
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)
Published: May 1, 2024
Abstract Background Adenosine A3 receptor (ADORA3) belongs to the adenosine families and role of ADORA3 in vascular dementia (VaD) is largely unexplored. The present study sought determine therapeutic antagonist a mouse model VaD. Methods GSE122063 dataset was selected screen differential expression genes pathways between VaD patients controls. A bilateral carotid artery stenosis (BCAS) established. cognitive functions were examined by novel object recognition test, Y maze fear conditioning test. white matter injury (WMI) 9.4 T MRI, western blot, immunofluorescence staining. mechanisms ADORA3‐regulated phagocytosis microglia using qPCR, dual staining, flow cytometry. Results elevated brain tissues indicated as key gene for GSE122063. In BCAS mice, predominantly corpus callosum. promotes microglial myelin debris facilitating cAMP/PKA/p‐CREB pathway thereby ameliorates WMI impairment mice. effect partially reversed inhibition cAMP/PKA pathway. Conclusions alleviates chronic ischemic modulating clearance microglia, which may be potential target treatment
Language: Английский
Citations
5
Synapse, Journal Year: 2023, Volume and Issue: 77(4)
Published: March 21, 2023
Vascular dementia (VaD) is a prevalent cause of after Alzheimer's disease. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hUCMSC-Evs) are critical for VaD treatment. We explored the mechanism hUCMSC-Evs in VaD. rat model was established by bilateral common carotid artery ligation and were extracted. rats injected with Evs through tail vein. Rat neurological scores, neural behaviors, memory learning abilities, brain tissue pathological changes, impairment evaluated Zea-Longa method, Morris water maze tests, HE staining, ELISA (through acetylcholine [ACH] dopamine [DA] assessment). Microglia M1/M2 polarization detected immunofluorescence staining. Pro-/anti-inflammatory factor levels homogenate, oxidative stress-related indicators, p-PI3K, PI3K, p-AKT, AKT, Nrf2 protein determined ELISA, kits, Western blot. jointly treated PI3K phosphorylation inhibitor Ly294002 hUCMSC-Evs. manifested increased function injury decreased cognitive ability, abnormal structure, obvious inflammatory infiltration, diminished ACH DA levels, microglial cells M1-polarized cells, ratio, inflammation, stress. alleviated damage rats, inhibited M1 polarization, stress tissues activated PI3K/AKT/Nrf2 pathway. partially averted effects on Briefly, pathway stress, thus protecting nerve functions.
Language: Английский
Citations
13
Journal of Alzheimer s Disease Reports, Journal Year: 2024, Volume and Issue: 8(1), P. 43 - 56
Published: Jan. 12, 2024
Dementia is a syndrome in which there deterioration memory, behavior, and the ability to perform everyday activities. Alzheimer's disease vascular dementia are most common forms of dementia. There evidence supporting hypothesis that inflammatory immune mechanisms involved Microglia, resident macrophage tissues central nervous system, play significant role neuroinflammation an important amyloid-β clearance brain, impaired microglial has also been shown be pathogenesis disease. However, abundant microglia have harmful actions Once activated, they can mediate uptake at neuronal synapses. They exacerbate tau pathology secrete deleterious factors directly or indirectly damage neurons. Thus, depending on stage disease, act both protectively detrimentally. Therefore, it still necessary continue with studies better understand Currently available drugs only improve cognitive symptoms, no impact progression not curative, so identifying studying new therapeutic approaches important. Considering played by this pathology, pointed out as possible approach. This manuscript aims address relationship between how could used for purposes.
Language: Английский
Citations
4
Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13
Published: Jan. 11, 2024
Background: Cognitive impairment (CI) is one of the major complications in chronic kidney disease patients, especially those with end-stage renal (ESRD). Limited biomarkers have been found that can significantly predict ESRD-associated cognitive decline. Objective: This cohort study aimed to investigate de novo for diagnosis CI. Methods: In this study, qualified samples were divided into control (with an estimated glomerular filtration rate (eGFR) of≥60 mL/min and a Mini-Mental State Examination (MMSE) score > 27), ESRD without CI (eGFR < 15 MMSE 27) groups. Levels plasma amyloid-β (Aβ)1 - 42, serum indoxyl sulfate, hematologic biochemical parameters measured. Results: Compared group, levels blood urea nitrogen, creatinine, sulfate elevated patients both Interestingly, had lowest albumin. contrast, Aβ 1 42 higher group than addition, ratio over albumin was or Importantly, area under receiver operating characteristic curve (AUROC) total population by 0.785 significant (p 0.05). Conclusions: has shown be biomarker prognosis
Language: Английский
Citations
4