Diets intervene osteoporosis via gut-bone axis

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 4, 2024

Osteoporosis is a systemic skeletal disease that seriously endangers the health of middle-aged and older adults. Recently, with continuous deepening research, an increasing number studies have revealed gut microbiota as potential target for osteoporosis, research concept gut-bone axis has gradually emerged. Additionally, intake dietary nutrients adoption patterns may affect microbiota, alterations in might also influence metabolic status host, thus adjusting bone metabolism. Based on axis, can participate modulation metabolism by altering abundance, diversity, composition microbiota. Herein, combined emerging literatures relevant studies, this review aimed to summarize impacts different components osteoporosis acting well underlying mechanisms proper recommendations.

Language: Английский

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Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 94, P. 102196 - 102196

Published: Jan. 12, 2024

Language: Английский

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Effect of gut microbiome modulation on muscle function and cognition: the PROMOTe randomised controlled trial

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 29, 2024

Abstract Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut play a role in anabolic resistance of older muscle, cognition. In this placebo controlled double blinded randomised trial 36 twin pairs (72 individuals), aged ≥60, each pair are block to receive either or prebiotic daily for 12 weeks. Resistance exercise branched chain amino acid (BCAA) supplementation is prescribed all participants. Outcomes physical function The carried out remotely using video visits, online questionnaires testing, posting equipment biological samples. supplement well tolerated results changed microbiome [e.g., increased relative Bifidobacterium abundance]. There no significant difference between the primary outcome chair rise time (β = 0.579; 95% CI −1.080-2.239 p 0.494). improves cognition (factor score versus −0.482; CI,−0.813, −0.141; 0.014)). Our demonstrate cheap readily available interventions improve our ageing population. We illustrate feasibility delivered trials people, which could reduce under-representation people clinical trials. ClinicalTrials.gov registration: NCT04309292.

Language: Английский

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Disentangling the Complexity of Nutrition, Frailty and Gut Microbial Pathways during Aging: A Focus on Hippuric Acid

Nutrients, Journal Year: 2023, Volume and Issue: 15(5), P. 1138 - 1138

Published: Feb. 24, 2023

Hippuric acid (HA) is a metabolite resulting from the hepatic glycine conjugation of benzoic (BA) or gut bacterial metabolism phenylalanine. BA generally produced by microbial metabolic pathways after ingestion foods vegetal origin rich in polyphenolic compounds, namely, chlorogenic acids epicatechins. It can also be present foods, either naturally artificially added as preservative. The plasma and urine HA levels have been used nutritional research for estimating habitual fruit vegetable intake, especially children patients with diseases. has proposed biomarker aging, since its influenced presence several age-related conditions, including frailty, sarcopenia cognitive impairment. Subjects physical frailty exhibit reduced HA, despite fact that excretion tends to increase aging. Conversely, subjects chronic kidney disease clearance, retention may exert toxic effects on circulation, brain kidneys. With regard older multimorbidity, interpreting result particularly challenging because at crossroads between diet, microbiota, liver function. Although these considerations not make ideal aging trajectories, study clearance provide valuable information disentangling complex interaction multimorbidity.

Language: Английский

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Bifidobacterium as a Potential Biomarker of Sarcopenia in Elderly Women

Nutrients, Journal Year: 2023, Volume and Issue: 15(5), P. 1266 - 1266

Published: March 3, 2023

Gut microbial dysbiosis influences the development of sarcopenia. This case-control study explored gut microbiota composition in elderly Chinese women with The information from 50 cases and controls was collected. Grip strength, body weight, mass index, skeletal muscle mass, energy intake, total high-quality protein intake were lower than (p < 0.05). metagenomic sequencing showed that phylum Bacteroides significantly reduced case group, whereas genus Prevotella more abundant Linear discriminant analysis (LDA) effect size 9 13 distinct taxa enriched control groups, respectively (LDA > 2, p 0.05), among which copri Bifidobacterium longum different 4, AUC 0.674 (95% CI: 0.539-0.756). Elderly sarcopenia exhibited compositions healthy controls.

Language: Английский

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Gut microbe-derived betulinic acid alleviates sepsis-induced acute liver injury by inhibiting macrophage NLRP3 inflammasome in mice

mBio, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Sepsis-induced acute liver injury (SALI) is a prevalent and life-threatening complication associated with sepsis. The gut microbiota plays crucial role in the maintenance of health development diseases. impact physical exercise on modulation has been well-documented. However, potential microbiome training-induced protection against SALI remains uncertain. Here, we discovered training ameliorated systemic inflammation septic mice. Notably, pre-depletion abolished protective effects Fecal transplantation treatment revealed that training-associated contributed to beneficial effect SALI. Exercise modulated metabolism Ligilactobacillus enriched betulinic acid (BA) levels Functionally, BA conferred by inhibiting hepatic inflammatory response bound inactivated hnRNPA2B1, thus suppressing NLRP3 inflammasome activation macrophages. Collectively, this study reveals involved SALI, microbiota-derived inhibits via hnRNPA2B1-NLRP3 axis, providing therapeutic strategy for Sepsis characterized dysregulated immune an infection leads multiple organ dysfunction. occurrence frequently observed during initial stage sepsis directly linked mortality intensive care unit. preventive well recognized, yet underlying mechanism poorly elucidated. alters mice, increasing abundance promoting generation BA. Additionally, supplementation can suppress macrophages binding thereby mitigating These results highlight response, which represents stride toward implementing microbiome-based strategies clinical management

Language: Английский

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Therapeutic Strategies to Modulate Gut Microbial Health: Approaches for Chronic Metabolic Disorder Management

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 127 - 127

Published: Feb. 13, 2025

Numerous recent studies have suggested that the composition of intestinal microbiota can trigger metabolic disorders, such as diabetes, prediabetes, obesity, syndrome, sarcopenia, dyslipidemia, hyperhomocysteinemia, and non-alcoholic fatty liver disease. Since then, considerable effort has been made to understand link between well role probiotics in modulation microbiota. The aim this review was summarize reviews individual articles on state art regarding ideal therapy with prebiotics order obtain reversion dysbiosis (alteration microbiota) eubiosis during diseases, diseases. This includes 245 eligible studies. In conclusion, a condition dysbiosis, or general, alteration microbiota, could be implicated development disorders through different mechanisms, mainly linked release pro-inflammatory factors. Several already demonstrated potential using treatment condition, detecting significant improvements specific symptoms These findings reinforce hypothesis lead generalized inflammatory picture negative consequences organs systems. Moreover, confirms beneficial effects diseases are promising, but more research is needed determine optimal probiotic strains, doses, administration forms for conditions.

Language: Английский

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Gut Microbiota and Aging: Traditional Chinese Medicine and Modern Medicine

Clinical Interventions in Aging, Journal Year: 2023, Volume and Issue: Volume 18, P. 963 - 986

Published: June 1, 2023

Abstract: The changing composition of gut microbiota, much like aging, accompanies people throughout their lives, and the inextricable relationship between both has recently attracted extensive attention as well. Modern medical research revealed that a series changes in microbiota are involved aging process organisms, which may be because modulates aging-related related to innate immunity cognitive function. At present, there is no definite effective method delay aging. However, Nobel laureate Tu Youyou’s on artemisinin inspired researchers study importance Traditional Chinese Medicine (TCM). TCM, an ancient alternative medicine, unique advantages preventive health care treating diseases it already formed independent understanding system. TCM practitioners believe mechanism mainly deficiency, pathological states such blood stasis, qi stagnation phlegm coagulation can exacerbate involves organs, including brain, kidney, heart, liver spleen. Our current led us realise indeed make some beneficial changes, improvement impairment. due multi-component multi-target nature exploration its action become extremely complex. While analysing this review explores similarities differences treatment methods mechanisms Medicine, order explore new approach combines regulate improve Keywords: traditional microbiota-gut-brain axis

Language: Английский

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High-fat diet induces sarcopenic obesity in natural aging rats through the gut–trimethylamine N-oxide–muscle axis

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

The lack of suitable animal models for sarcopenic obesity (SO) limits in-depth research into the disease. Emerging studies have demonstrated that gut dysbiosis is involved in development SO. As importance microbial metabolites starting to unveil, it necessary comprehend specific associated with microbiota and We aimed investigate whether high-fat diet (HFD) causes SO natural aging are linking HFD Young rats received or control 80 weeks, obesity-related metabolic disorders sarcopenia were measured. 16S rRNA sequencing non-targeted targeted metabolomics methods used detect fecal serum metabolites. Gut barrier function was evaluated by intestinal integrity permeability. Trimethylamine N-oxide (TMAO) treatment further conducted verification. resulted body weight gain, dyslipidemia, impaired glucose tolerance, insulin resistance, systemic inflammation rats. also caused decreases muscle mass, strength, function, fiber cross-sectional area increase fatty infiltration nontargeted analysis indicated contributed dysbiosis, mainly characterized increases deleterious bacteria TMAO. destroyed increased permeability, as reducing levels colonic mucin-2, tight junction proteins, goblet cells elevating level fluorescein isothiocyanate-dextran 4. Correlation showed a positive association between TMAO In addition, aggravated HFD-fed aged through regulating ROS-AKT/mTOR signaling pathway. leads rats, partially gut-microbiota-TMAO-muscle axis.

Language: Английский

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Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2367 - 2367

Published: May 18, 2023

Sarcopenia, the age-related loss of muscle mass and function increasing risk disability adverse outcomes in older people, is substantially influenced by dietary habits. Several studies from animal models aging wasting indicate that intake specific polyphenol compounds can be associated with myoprotective effects, improvements strength performance. Such findings have also been confirmed a smaller number human studies. However, gut lumen, polyphenols undergo extensive biotransformation microbiota into wide range bioactive compounds, which contribute to bioactivity on skeletal muscle. Thus, beneficial effects may consistently vary across individuals, depending composition metabolic functionality bacterial communities. The understanding such variability has recently improved. For example, resveratrol urolithin interaction produce different biological according metabotype. In frequently characterized dysbiosis, overrepresentation opportunistic pathogens, increased inter-individual variability, actions phenolic at level. These interactions should taken great consideration for designing effective nutritional strategies counteract sarcopenia.

Language: Английский

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