Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(5), P. 937 - 938
Published: Sept. 22, 2023
Language: Английский
Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(2), P. 900 - 907
Published: Sept. 5, 2023
Language: Английский
Citations
25
Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 7, 2025
Cognitive impairment (CI) is a condition in which an individual experiences noticeable thinking abilities. Long-term exposure to aluminum (Al) can cause CI. This study aimed determine the relationship between CI and MRI-related changes postroom workers exposed Al. Thirty patients with 25 healthy controls were recruited. Plasma levels measured using inductively coupled plasma-mass spectrometry. function was assessed Montreal Assessment (MoCA) auditory-verbal learning test (AVLT). All participants underwent magnetic resonance imaging scans. 3D T1-weighted anatomical images resting-state functional data acquired, voxel-based morphometry ROI-based FC used for analysis. A mediation analysis also conducted. significantly higher group than normal control group. The gray matter (GM) volume left caudate bilateral hippocampus lower positively correlated cognitive scale scores. There no significant difference connectivity (FC) whole brain two groups. Significant alterations hippocampal observed certain areas, mainly cerebellar vermis, middle frontal gyrus (BA9), right superior relative supplementary motor area (BA6). coefficients associated Furthermore, plasma Al concentration negatively score, GM volume, coefficient vermis. Mediation showed alteration of vermis could explained 19.80-32.07% effect MoCA scores change related exposure, besides acted as indirect mediator (68.75%) association AVLT delayed recall Our indicates that structure special domain, especially hippocampus, are Al-induced These regions partly explain on impairment.
Language: Английский
Citations
1
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 29, 2025
Language: Английский
Citations
1
Health & Place, Journal Year: 2024, Volume and Issue: 89, P. 103330 - 103330
Published: Aug. 16, 2024
Language: Английский
Citations
4
Environmental Science and Pollution Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 8, 2025
Abstract Exposome represents one of the most pressing issues in environmental science research field. However, a comprehensive summary worldwide human exposome is lacking. We aimed to explore bibliometric characteristics scientific publications on exposome. A analysis from 2005 December 2024 was conducted using Web Science accordance with PRISMA guidelines. Trends/hotspots were investigated keyword frequency, co-occurrence, and thematic map. Sex disparities terms citations examined. From 2024, 931 published 363 journals written by 4529 authors 72 countries. The number tripled during last 5 years. Publications females (51% as first 34% authors) cited fewer times (13,674) than males (22,361). Human studies mainly focused air pollution, metabolomics, chemicals (e.g., per- polyfluoroalkyl substances (PFAS), endocrine-disrupting chemicals, pesticides), early-life exposure, biomarkers, microbiome, omics, cancer, reproductive disorders. Social built environment factors, occupational multi-exposure, digital exposure screen use), climate change, late-life received less attention. Our results uncovered high-impact countries, institutions, journals, references, authors, key trends/hotspots. use technologies sensors, wearables) data artificial intelligence) has blossomed overcome challenges could provide valuable knowledge toward precision prevention. risk scores represent promising avenue.
Language: Английский
Citations
0
npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)
Published: May 7, 2025
Language: Английский
Citations
0
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: May 11, 2025
Endocrine-disrupting chemicals (EDCs) are widespread environmental contaminants that interfere with hormonal regulation, affecting metabolism, reproduction, neurodevelopment, and overall health. This review presents an overview of recent evidence on the health effects biological mechanisms EDCs, a focus their impact balance quality life. An integrative literature was conducted using 28 peer-reviewed articles published between 2020 2025, retrieved from databases such as PubMed, Scopus, ScienceDirect. The selected studies explored physiological pathological EDCs in humans. Compounds, bisphenol A, phthalates, polychlorinated biphenyls (PCBs), can mimic or block hormones, disrupt endocrine signaling pathways, bioaccumulate tissues. Exposure, especially during critical developmental windows, is linked to metabolic disorders, infertility, neurodevelopmental delays, hormone-sensitive cancers. Common exposure sources include food, air, household dust, water, personal care products. Key action involve receptor binding interference, oxidative stress, epigenetic alterations. pose significant growing threat public health, warranting urgent regulatory measures, increased awareness, continued research mitigate long-term consequences.
Language: Английский
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: May 18, 2023
Extracellular vesicles (EVs or exosomes) are well described for bacterial pathogens associated with our gastrointestinal system, and more recently as a novel mechanism environmental persistence, dissemination infection human enteric viruses. However, the roles played by EVs in ancient arms race that continues between amoebae one of their prey, Legionella pneumophila, is poorly understood. At best we know intracellular containing mix prey species, which also provides an enhanced niche bacteriophage infection/spread. Free-living amoeba-associated have been recognized to resistance disinfection stressors, adding previously understood (but relatively few species of) bacteria sequestered within amoebal cysts. focus current work review likely impacts large numbers respiratory-sized numerous L. pneumophila cells studied pure biofilm systems mixed species. These encapsulated orders magnitude resistant than free cells, engineered residual disinfectants could promote evolution (including AMR), virulence EV release. All these key features dead-end pathogen post lung infection. Traditional single-hit models used estimate probability infection/disease critical concentrations via quantitative microbial risk assessments may need change. In short, recognizing EV-packaged highly virulent units transmission legionellae, modulate/avoid host immune responses. Key data gaps raised previous conceptual model expanded upon clarify where play role promoting inform wholistic management program proactively control legionellosis.
Language: Английский
Citations
8
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 946, P. 174313 - 174313
Published: July 2, 2024
Language: Английский
Citations
2
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116960 - 116960
Published: Aug. 28, 2024
Accumulating observational studies have linked particulate air pollutants to neurodegenerative diseases (NDDs). However, the causal links and direction of their associations remain unclear. Therefore, we adopted a two-sample Mendelian randomization (TSMR) design using GWAS-based genetic instruments (PM
Language: Английский
Citations
1