Genes,
Journal Year:
2023,
Volume and Issue:
15(1), P. 16 - 16
Published: Dec. 21, 2023
Biological
clock
technologies
are
designed
to
assess
the
acceleration
of
biological
age
(B-age)
in
diverse
cell
types,
offering
a
distinctive
opportunity
toxicogenomic
research
explore
impact
environmental
stressors,
social
challenges,
and
unhealthy
lifestyles
on
health
impairment.
These
clocks
also
play
role
identifying
factors
that
can
hinder
aging
promote
healthy
lifestyle.
Over
past
decade,
researchers
epigenetics
have
developed
testing
methods
predict
chronological
organisms.
rely
assessing
DNA
methylation
(DNAm)
levels
at
specific
CpG
sites,
RNA
levels,
various
biomolecules
across
multiple
tissues,
entire
Commonly
known
as
‘biological
clocks’
(B-clocks),
these
estimators
hold
promise
for
gaining
deeper
insights
into
pathways
contributing
development
age-related
disorders.
They
provide
foundation
devising
biomedical
or
interventions
prevent,
reverse,
mitigate
This
review
article
provides
concise
overview
epigenetic
explores
their
susceptibility
stressors.
Biological Research For Nursing,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
Purpose:
To
examine
the
association
between
trajectories
of
physical
activity
(PA)
over
12
years
and
epigenetic
age
acceleration
(EAA)
in
3600
middle-aged
older
adults
Health
Retirement
Study.
Methods:
Latent
variable
mixture
modeling
identified
subgroups
with
similar
vigorous,
moderate,
light
PA
from
2004
to
2016.
Six
EAAs,
including
Horvath’s
acceleration,
Hannum’s
GrimAge
PhenoAge
DunedinPoAm
ZhangAA
were
calculated
by
regressing
on
chronological
Linear
regression
models
tested
associations
controlling
for
age,
sex,
race,
education,
smoking,
alcohol
consumption,
depression.
Results:
Five
each
type.
Moderate
stable
or
slightly
changed
time.
In
contrast,
vigorous
either
consistently
low
(27.2%),
increased
at
a
level
(14.9%),
decreased
moderate
levels
(25.9%),
high
(11.9%),
(20.1%).
negatively
associated
EAA
across
six
clocks
(
p
<
.01).
Light
not
any
EAA.
Vigorous
slower
=
.004)
.03).
Participants
that
showed
increasing
had
compared
those
PA.
Conclusion:
but
light,
EAAs.
Frontiers in Public Health,
Journal Year:
2025,
Volume and Issue:
13
Published: April 16, 2025
Background
Cardiometabolic
diseases
are
prevalent
among
ageing
populations
and
have
a
close
association
with
frailty.
However,
the
cumulative
impact
multiple
cardiometabolic
on
frailty
remains
underexplored.
Methods
This
study
used
data
from
four
international
cohorts
–
HRS,
CHARLS,
ELSA
SHARE
to
examine
correlation
between
(CMD).
The
index
was
for
assessing
statistical
analyses
were
performed
as
means
of
analysing
number
conditions
severity.
Linear
regression
models
employed
evaluate
associations
CMD
Results
found
that
increased,
rose
significantly
[one
disease,
β
=
7.80
(95%
CI:
7.70
7.90)
p
<
0.05;
two
diseases,
17.92
17.76
18.08)
three
28.79
28.41
29.17)
0.05].
Stroke
most
pronounced
(
12.34
[95%CI
12.20
12.48]
0.05)
coexistence
served
amplify
symptoms
Conclusion
highlights
compounded
also
emphasizes
necessity
early
intervention.
Nursing Outlook,
Journal Year:
2025,
Volume and Issue:
73(3), P. 102396 - 102396
Published: April 21, 2025
Precision
health
is
a
person-centered
approach
to
and
well-being
that
operationalized
through
evaluating
omics-level
profiles
their
associations
with
the
exposome.
A
precision
addresses
challenge
"one
size
does
not
fit
all"
in
management
of
an
individual's
health.
The
purpose
this
white
paper
introduce
Health
Model
its
application
research
clinical
care.
An
expert
panel
reviewed
synthesized
extant
literature
related
health,
current
state
omics'
science,
common
exposome
factors
influence
health/illness
continuum.
case
study
provides
framework
for
Model.
key
domains
are
defined
serve
as
platform
development
Application
will
provide
inclusive,
equitable,
Neurochemistry International,
Journal Year:
2023,
Volume and Issue:
171, P. 105627 - 105627
Published: Oct. 11, 2023
Changes
in
gene
expression
are
involved
many
brain
functions.
Epigenetic
processes
modulate
by
histone
modification
and
DNA
methylation
or
RNA-mediated
processes,
which
is
important
for
function.
Consequently,
epigenetic
changes
also
a
part
of
diseases
such
as
mental
illness
addiction.
Understanding
the
role
different
factors
on
epigenome
may
help
us
understand
function
brain.
This
review
discussed
effects
caffeine,
lipids,
addictive
substances,
physical
activity,
pollutants
their
modulatory
Genes,
Journal Year:
2023,
Volume and Issue:
15(1), P. 16 - 16
Published: Dec. 21, 2023
Biological
clock
technologies
are
designed
to
assess
the
acceleration
of
biological
age
(B-age)
in
diverse
cell
types,
offering
a
distinctive
opportunity
toxicogenomic
research
explore
impact
environmental
stressors,
social
challenges,
and
unhealthy
lifestyles
on
health
impairment.
These
clocks
also
play
role
identifying
factors
that
can
hinder
aging
promote
healthy
lifestyle.
Over
past
decade,
researchers
epigenetics
have
developed
testing
methods
predict
chronological
organisms.
rely
assessing
DNA
methylation
(DNAm)
levels
at
specific
CpG
sites,
RNA
levels,
various
biomolecules
across
multiple
tissues,
entire
Commonly
known
as
‘biological
clocks’
(B-clocks),
these
estimators
hold
promise
for
gaining
deeper
insights
into
pathways
contributing
development
age-related
disorders.
They
provide
foundation
devising
biomedical
or
interventions
prevent,
reverse,
mitigate
This
review
article
provides
concise
overview
epigenetic
explores
their
susceptibility
stressors.
