Mechanosensitive Piezo channels and their potential roles in peripheral auditory perception DOI Creative Commons
Zhan‐Miao Yi,

Ge Yin,

Chunjiang Wei

et al.

Brain‐X, Journal Year: 2024, Volume and Issue: 2(3)

Published: Sept. 1, 2024

Abstract Hearing sound and responding to external internal mechanical stimuli requires specific proteins as mechanotransducers that convert forces into biological signals. However, our understanding of the mechanotransduction process in inner ear is still incomplete. Mechanically activated ion channels, PIEZO1 PIEZO2, are widely distributed throughout body play essential roles. Recent studies have discovered Piezo channels expressed hair cells, suggesting their potential involvement auditory perception. This review summarizes existing discoveries about including structure, mechanogating mechanisms, general physiological roles, explicitly focusing on systems. roles ultrasound perception, generation anomalous current, cell development, potentially normal mechanoelectrical transduction cells. Collectively, this aims provide a new perspective channel its

Language: Английский

The Alteration of Microglial Calcium Homeostasis in Central Nervous System Disorders: A Comprehensive Review DOI Creative Commons
ATM Hasibul Hasan, Faria Tasnim, Md. Aktaruzzaman

et al.

Neuroglia, Journal Year: 2024, Volume and Issue: 5(4), P. 410 - 444

Published: Oct. 21, 2024

Microglia, the unique and motile immune cells of central nervous system (CNS), function as a security guard in maintaining CNS homeostasis, primarily through calcium signaling. The dynamics microglia control important functions such phagocytosis, cytokine release, migration. Calcium dysregulation has been linked to several disorders, like Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), ischemic stroke (IS). entering channels voltage-gated (VGCCs), store-operated entry (SOCE), transient receptor potential (TRP) is essential for microglial activation pro-inflammatory responses. Under pathological conditions, formation amyloid-β plaques AD, aggregation α-synuclein PD, oxidative stress MS, exacerbates neuroinflammation, mitochondrial dysfunction, neurodegeneration. Therapeutic strategies targeting signaling pathways, using channel blockers antioxidant interventions, show promise alleviating slowing down progression. This review summarizes underlying mechanisms therapeutic benefits restoring balance disorders.

Language: Английский

Citations

9
Ca2+ excitability of glia to neuromodulator octopamine in Drosophila living brain is greater than that of neurons DOI Creative Commons

Urška Černe,

Anemari Horvat,

Ena Sanjković

et al.

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(2)

Published: Jan. 13, 2025

Octopamine in the Drosophila brain has a neuromodulatory role similar to that of noradrenaline mammals. After release from Tdc2 neurons, octopamine/tyramine may trigger intracellular Ca We expressed Octopamine-stimulated In optic lobes, astrocytes, not appear be sole responders low concentration octopamine signals, and therefore likely drive synaptic plasticity visual processing. Given interconnectivity lobes with other regions, octopaminergic signals acting through lobe astrocytes also influence higher-order functions including learning memory.

Language: Английский

Citations

1
Targeting Microglia in Alzheimer’s Disease: Pathogenesis and Potential Therapeutic Strategies DOI Creative Commons

Zhongqing Sun,

Xin Zhang, Kwok‐Fai So

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 833 - 833

Published: July 11, 2024

Microglia, as resident macrophages in the central nervous system, play a multifunctional role pathogenesis of Alzheimer’s disease (AD). Their clustering around amyloid-β (Aβ) deposits is core pathological feature AD. Recent advances single-cell RNA sequencing (scRNA-seq) and single-nucleus (snRNA-seq) have revealed dynamic changes microglial phenotypes over time across different brain regions during aging AD progression. As advances, microglia primarily exhibit impaired phagocytosis Aβ tau, along with release pro-inflammatory cytokines that damage synapses neurons. Targeting has emerged potential therapeutic approach for Treatment strategies involving can be broadly categorized into two aspects: (1) enhancing function: This involves augmenting their phagocytic ability against cellular debris (2) mitigating neuroinflammation: Strategies include inhibiting TNF-α signaling to reduce neuroinflammatory response triggered by microglia. Clinical trials exploring microglia-related approaches treatment garnered attention. Additionally, natural products show promise beneficial effects suppressing inflammatory responses. Clarifying dynamics, understanding roles, novel will advance our fight

Language: Английский

Citations

7
Toward an ion‐channel‐centric approach to ultrasound neuromodulation DOI
Martin Loynaz Prieto, Merritt Maduke

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 56, P. 101355 - 101355

Published: Feb. 15, 2024

Language: Английский

Citations

5
GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury DOI Creative Commons
Xin Zhang, Xinyu Liu, Qianxi Li

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317683 - e0317683

Published: Jan. 22, 2025

Motor dysfunction and muscle atrophy are typical symptoms of patients with spinal cord injury (SCI). Exercise training is a conventional physical therapy after SCI, but exercise intervention alone may have limited efficacy in reducing secondary promoting nerve regeneration functional remodeling. Our previous research found that intramedullary pressure SCI one the key factors affecting prognosis. It has been reported GsMTx-4, specific blocker mechanosensitive ion channels Piezo1, can protect integrity neuromuscular junction promote regeneration, thus potential as therapeutic agent for SCI. In this study, we observed combined separate effect GsMTx-4 on structure soleus motor function rats At 42 days post-injury, compared rats, Basso–Beattie–Bresnahan score (P = 0.0007) Gait Symmetry 0.0002) were significantly improved combination therapy. On histology rat muscle, treatment increased wet weight ratio, fiber cross-sectional area acetylcholinesterase (all P<0.0001). tissue, neuron counts BDNF levels, reduced percentage TUNEL-positive cells physiology succinate dehydrogenase expression (P<0.0001), while α-glycerophosphate (P<0.0001) GDF8 protein 0.0008) decreased. Results indicate effectively improves histopathology enhancing function. This study was conducted animal models, it offers insights treatment, advancing understanding lower limb pathology post-SCI. Further needed clinical validation future.

Language: Английский

Citations

0
Emerging roles of mechanically activated ion channels in autoimmune disease DOI

Zhiru Zeng,

Engeng Chen, Jing Xue

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(7), P. 103813 - 103813

Published: April 7, 2025

Language: Английский

Citations

0
Piezo1 in microglial cells: Implications for neuroinflammation and tumorigenesis DOI Creative Commons
Bo Yang, Zhenyu Li, Peiliang Li

et al.

Channels, Journal Year: 2025, Volume and Issue: 19(1)

Published: April 13, 2025

Microglia, the central nervous system (CNS) resident immune cells, are pivotal in regulating neurodevelopment, maintaining neural homeostasis, and mediating neuroinflammatory responses. Recent research has highlighted importance of mechanotransduction, process by which cells convert mechanical stimuli into biochemical signals, microglial activity. Among various mechanosensitive channels, Piezo1 emerged as a key player microglia, influencing their behavior under both physiological pathological conditions. This review focuses on expression role particularly context neuroinflammation tumorigenesis. We explore how mediates responses to changes within CNS, such alterations tissue stiffness fluid shear stress, common conditions like multiple sclerosis, Alzheimer's disease, cerebral ischemia, gliomas. The also discusses potential targeting for therapeutic intervention, given its involvement modulation activity impact disease progression. integrates findings from recent studies provide comprehensive overview Piezo1's mechanistic pathways function. These insights illuminate new possibilities developing targeted therapies addressing CNS disorders with mechanics.

Language: Английский

Citations

0
ω3-PUFA alleviates neuroinflammation by upregulating miR-107 targeting PIEZO1/NFκB p65 DOI
Hailin Liu, Lian Zhou, Pengcheng Yi

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 111996 - 111996

Published: April 4, 2024

Language: Английский

Citations

3
LOX-Mediated ECM Mechanical Stress Induces Piezo1 Activation in Hypoxic-Ischemic Brain Damage and Identification of Novel Inhibitor of LOX DOI Creative Commons

Dongya Jiang,

Jing Zhao, Jie Zheng

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103346 - 103346

Published: Sept. 7, 2024

Language: Английский

Citations

3
Piezo1 is a Pathogenic Gene and Therapeutic Target for Neurological Diseases DOI
Hui Wang,

Zhixian Gou,

Shunrui Chen

et al.

International Journal of Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: April 25, 2025

Piezo1 is a ubiquitously expressed non-selective cation channel protein found across various species. It possesses the ability to detect and respond external mechanical forces, converting cues into intracellular bioelectrical events, thereby facilitating propagation of electrochemical signals. Within nervous system, integral synaptogenesis myelination, modulation pro-inflammatory mediators, neuropathic pain, cognitive processes, angiogenesis, regulation cerebral hemodynamics, consequently impacting pathogenesis progression neurological disorders. This review meticulously summarizes synthesizes existing literature provide an exhaustive overview Piezo1's roles mechanisms in spectrum diseases, including neurodegenerative disorders, cerebrovascular accidents, traumatic brain injuries, gliomas, multiple sclerosis, epilepsy. Additionally, it explores potential therapeutic applications targeting Piezo1. The discussion also encompasses current research limitations, imperative need for future investigations, prospective strategies. Our analysis indicates that susceptibility gene conditions, its expression inhibition may confer benefits. In summary, this comprehensive offers novel insights involvement diseases establishes theoretical groundwork development Piezo1-targeted interventions.

Language: Английский

Citations

0