Revitalizing osteoporotic bone repair via multilevel ROS scavenging and osteoimmune regulating hydrogel

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112305 - 112305

Published: Feb. 1, 2025

Language: Английский

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Nat10-mediated N4-acetylcytidine modification enhances Nfatc1 translation to exacerbate osteoclastogenesis in postmenopausal osteoporosis

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(15)

Published: April 7, 2025

Increased differentiation or activity of osteoclasts is the key pathogenic factor postmenopausal osteoporosis (PMOP). N4‐acetylcytidine (ac4C) modification, catalyzed by Nat10, a novel posttranscriptional mRNA modification related to many diseases. However, its impact on regulating osteoclast activation in PMOP remains uncertain. Here, we initially observed that Nat10-mediated ac4C positively correlates with monocytes and low bone mass PMOP. The specific knockout Nat10 remodelin, inhibitor, alleviates ovariectomized (OVX)-induced loss downregulating differentiation. Mechanistically, epitranscriptomic analyses reveal nuclear activated T cells cytoplasmic 1 (Nfatc1) downstream target during Subsequently, translatomic results demonstrate enhances translation efficiency (TE) Nfatc1, thereby inducing Nfatc1 expression consequent maturation. Cumulatively, these findings promotive role from field RNA modifications suggest can be epigenetic therapy for preventing

Language: Английский

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Bioengineered bacterial extracellular vesicles for targeted delivery of an osteoclastogenesis-inhibitory peptide to alleviate osteoporosis

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113751 - 113751

Published: April 1, 2025

Language: Английский

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Scoping review exploring the impact of hip fracture in older adults with cognitive impairment or dementia

BMJ Open, Journal Year: 2025, Volume and Issue: 15(4), P. e093893 - e093893

Published: April 1, 2025

Objectives This review summarises the impact of hip fractures on health outcomes including subsequent falls, hospitalisation, length hospital stay (LOS), functional status, quality life and mortality in older adults with cognitive impairment or dementia. It also explores risk institutionalisation following a fracture this population. Design A scoping Arksey O’Malley framework guided by Joanna Briggs Institute methodology adheres to Preferred Reporting Items for Systematic Reviews Meta-analyses extension Scoping guidelines. Data sources comprehensive search strategy was developed MEDLINE, EMBASE, CINAHL grey literature, additional references identified through citation searching Web Science. Eligibility criteria Studies were included if they examined dementia who experienced reported related life, institutionalisation. extraction synthesis Study selection data conducted independently two reviewers using Covidence software. narrative approach employed summarise findings identify key themes, patterns gaps literature. Results We 30 studies reporting fracture. Overall, indicated that individuals have higher hospitalisation rates, poorer walking ability outcomes, as well reduced posthip The LOS inconsistent across studies, some shorter others indicating longer LOS. Individuals consistently exhibit rates at days, 90 days 1-year postfracture compared those without found 21 evaluated Older significantly more likely be institutionalised fracture, nearly five times failing return home increased persists up is particularly pronounced severe impairment, nursing placement observed among fractures. Conclusion experience worse fractures, mortality, postfracture. Future research should focus developing effective strategies prevention, optimising osteoporosis treatment high-risk population, targeted interventions improve reduce vulnerable

Language: Английский

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Body Composition and Alzheimer’s Disease: A Holistic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9573 - 9573

Published: Sept. 4, 2024

Alzheimer’s disease (AD) represents a significant global health challenge and affects approximately 50 million people worldwide. This overview of published reviews provides comprehensive understanding the intricate correlations between AD body composition, focusing particularly on obesity. We used systematic approach to collect analyze relevant topic obesity disease. A search electronic databases, including PubMed, MEDLINE, Google Scholar, was conducted. searched keywords such as “Alzheimer’s disease”, “body composition”, “lean mass”, “bone “fat mass”. considered only written within past 5 years in English. Fifty-six were identified that shed light multiple connections composition. The review involves several aspects, impact lean mass, bone endocrinological factors related obesity, well inflammation, neuroinflammation, molecular/genetic factors. findings highlight complex interplay these elements development AD, underscoring need for holistic approaches reduce risk explore innovative strategies diagnosis, prevention, treatment.

Language: Английский

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Gut microbiome and bone health: update on mechanisms, clinical correlations, and possible treatment strategies

Osteoporosis International, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 7, 2024

Language: Английский

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Impact of dementia and mild cognitive impairment on bone health in older people

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 37(1)

Published: Dec. 27, 2024

Mild cognitive impairment, dementia and osteoporosis are common diseases of ageing and, with the increasingly global population, increasing in prevalence. These conditions closely associated, shared risk factors, underlying biological mechanisms potential direct causal pathways. In this review, epidemiological mechanistic links between mild skeletal health explored. Discussion will focus on how changes brain bone signalling can underly associations these conditions, consider molecular cellular drivers context inflammation gut microbiome. There is a complex interplay nutritional changes, which may precede or follow onset impairment (MCI) dementia, health. Polypharmacy patients MCI there difficult prescribing decisions to be made due elevated falls associated many drugs used for problems, consequently increase fracture risk. Some medications prescribed directly impact addition, have difficulty remembering medication without assistance, meaning that but not taken. Cognitive improved delayed by physical activity exercise, evidence additional benefits fractures. Research gaps priorities aim reducing burden fractures people also discussed.

Language: Английский

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EFFECTIVENESS OF REHABILITATION OF FUNCTIONAL CONSEQUENCES OF OSTEOPOROTIC RADIUS FRACTURE IN ELDERLY WOMEN WITH DEMENTIA

Art of Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 156 - 161

Published: March 28, 2024

Мета: оцінити ефективність впливу реабілітаційної програми на функціональний стан верхньої кінцівки у жінок похилого віку з наслідками перелому дистального метаепіфізу променевої кістки та деменцією. Методи. Обстежено 82 жінки віку. Контрольну групу склали 23 нетравмовані жінки. Групу порівняння переломом кістки, без ознак деменції, які отримували реабілітацію згідно відповідним протоколом. Основну 1 аналогічним переломом, деменцією, 2 за розробленою програмою (терапевтичні вправи, функціональне тренування, «MAPS THERAPY»; PNF; мобілізація променево-зап’ясткового суглоба; масаж кінцівки; кінезіологічне тейпування; тренування додатку «ReHand», когнітивна реабілітація) тривалістю місяці. Ефективність оцінювали Gartland & Werley Score, Nine-hole peg test, ABILIНAND, DASH. Результати. У виявлено задовільний результат лікування (Gartland Score), що призвело до порушення швидкості рухів (Nine-hole test), погіршення функціонування (АBILIHAND, DASH). Стан деменцією АBILIHAND, DASH був статистично значущо гіршим, ніж нормальним когнітивним статусом (р<0,05). Застосування реабілітації, розробленої урахуванням особливостей когнітивного стану із використанням сучасних методів реабілітації продемонструвало кращий усіма досліджуваними параметрами (р<0,05), порівняно групою, яка займалась загальними рекомендаціями клінічного протоколу. Висновки. Програма для створена наявності дефекту, продемонструвала свою через значуще покращення відносно вихідного результату результатів стандартної реабілітації.

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Correction of the fall risk as a cause of the distal metaepiphysis radius fracture in elderly women with dementia by physical therapy means

Published: Jan. 1, 2024

Purpose: to assess the effectiveness of physical therapy program on fall risk parameters in elderly women with dementia and consequences an osteoporotic radius distal metaepiphysis fracture. Materials methods. 76 were examined. The control group consisted without upper limb injuries. comparison fracture signs who received rehabilitation according appropriate medical care protocol. main fracture, MMSE. They divided into two subgroups: first, which clinical protocol, second, taking account (therapeutic exercises, functional training, «MAPS THERAPY»; «Blasepod» simulator; «ReHand» application, PNF therapy; massage; kinesiological taping; cognitive rehabilitation) lasting 2 months. was assessed by Functional Gait Assessment, Short Physical Performance Battery, ABC Scale, Berg Balance Fall efficacy scale. Results. In women, disorders static dynamic balance (Functional Battery), impairment activities daily living (ABC Scale), falling (Berg Scale) fear (Fall scale) found. condition scale statistically significantly worse than normal status (p<0.05). developed revealed a better effect indicators compared initial all studied (р<0.05). Conclusions. Creating for after falls, increases recovery helps reduce risk.

Language: Английский

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Daily consumption of ultra-high hydrostatic pressurized brown rice improves cognitive, mental, and bone health in the elderly: A 12-month, single blind, parallel-group randomized trial

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Purpose Age-related cognitive and psychiatric impairments are related to bone fragility. We reported that ultra-high hydrostatic pressurized brown rice (UBR) consumption helps maintain function mineral density (BMD), but their association remains unexplored. This study evaluated the effects of UBR for 12 months on mental with BMD in elderly. Methods Fortyfour participants (65–85 years) were randomly assigned either white (WR) (n = 22) or group, received 200 g WR 100 daily months, respectively. At baseline 12-month, Mini-Mental State Examination (MMSE) Cognitive Assessment Dementia, iPad version (CADi) measured function. Apathy depression assessed using Starkstein apathy scale Zung’s self-rated (SDS), Calcaneal was an ultrasound densitometer converted percentage Young-Adult Mean (%YAM). Results Twenty each group completed 12-month trial high adherence. Twelve-month intake significantly improved MMSE, CADi, scores, %YAM elderly compared intake. In addition, apathy, SDS scores correlated health index %YAM. No adverse events attributed intervention. Conclusion These results suggest may improve age-related impairments, retained BMD; potentially combating dementia osteoporosis Clinical trials registration: retrospectively registered Februaly 9th 2024, at UMIN Trials Registry as UMIN000053587.

Language: Английский

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