AJP Renal Physiology,
Journal Year:
2024,
Volume and Issue:
327(3), P. F363 - F372
Published: Sept. 1, 2024
Epithelial-to-mesenchymal
transition
(EMT)
is
considered
one
of
the
senescence
processes.
Antisenescence
therapies
may
effectively
reduce
EMT
in
peritoneal
dialysis
models.
Human
mesothelial
cells
treated
with
glucose
show
an
increase
and
markers;
however,
empagliflozin
attenuates
these
changes.
Mice
undergoing
exhibit
increased
markers,
which
are
decreased
by
empagliflozin.
These
findings
suggest
that
emerge
as
a
novel
strategy
for
prevention
or
treatment
fibrosis.
World Journal of Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
14(2)
Published: June 13, 2024
Mitochondrial
dysfunction
is
a
key
driver
of
cardiovascular
disease
(CVD)
in
metabolic
syndrome
and
diabetes.
This
promotes
the
production
reactive
oxygen
species
(ROS),
which
cause
oxidative
stress
inflammation.
Angiotensin
II,
main
mediator
renin-angiotensin-aldosterone
system,
also
contributes
to
CVD
by
promoting
ROS
production.
Reduced
activity
sirtuins
(SIRTs),
family
proteins
that
regulate
cellular
metabolism,
worsens
stress.
Reduction
energy
mitochondria
common
feature
all
disorders.
High
SIRT
levels
5’
adenosine
monophosphate-activated
protein
kinase
signaling
stimulate
hypoxia-inducible
factor
1
beta,
ketosis.
Ketosis,
turn,
increases
autophagy
mitophagy,
processes
clear
cells
debris
protect
against
damage.
Sodium-glucose
cotransporter-2
inhibitors
(SGLT2i),
class
drugs
used
treat
type
2
diabetes,
have
beneficial
effect
on
these
mechanisms.
Randomized
clinical
trials
shown
SGLT2i
improves
cardiac
function
reduces
rate
renal
events.
increase
mitochondrial
efficiency,
reduce
inflammation,
strengthen
tissues.
These
findings
suggest
hold
great
potential
for
treatment
CVD.
Furthermore,
they
are
proposed
as
anti-aging
drugs;
however,
rigorous
research
needed
validate
preliminary
findings.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(22), P. 6972 - 6972
Published: Nov. 19, 2024
Background:
Chronic
obstructive
pulmonary
disease
(COPD)
is
commonly
associated
with
ageing,
the
prevalence
and
severity
increasing
by
age.
Smoking-induced
premature
ageing
thought
to
contribute
COPD,
particularly
lung
emphysema.
This
study
aimed
explore
relationship
between
function
impairment
skin
texture,
as
a
marker
of
biological
or
in
COPD
patients.
Methods:
A
subcohort
from
COSYCONET
COPD-study
was
analyzed,
where
skin-relief
replicas
eye’s
outer
corner
mid-lower
inner
arm
were
collected,
along
semi-quantitative
facial
photographs.
We
examined
correlation
parameters
function,
diffusing
capacity
(TLCO)
an
indicator
Results:
Among
46
patients
(69
±
8
years,
52%
female),
texture
forearm,
but
not
eye
corner,
significantly
TLCO%
predicted,
higher
roughness
correlating
lower
TLCO
(p
=
0.015).
persisted
after
adjusting
for
age,
BMI,
sex,
pack
smoking
status.
No
significant
associations
found
Conclusions:
These
findings
suggest
that
systemic
reflected
linked
Skin
markers
may
be
valuable
future
interventional
studies
involving
anti-ageing
treatments.
AJP Renal Physiology,
Journal Year:
2024,
Volume and Issue:
327(3), P. F363 - F372
Published: Sept. 1, 2024
Epithelial-to-mesenchymal
transition
(EMT)
is
considered
one
of
the
senescence
processes.
Antisenescence
therapies
may
effectively
reduce
EMT
in
peritoneal
dialysis
models.
Human
mesothelial
cells
treated
with
glucose
show
an
increase
and
markers;
however,
empagliflozin
attenuates
these
changes.
Mice
undergoing
exhibit
increased
markers,
which
are
decreased
by
empagliflozin.
These
findings
suggest
that
emerge
as
a
novel
strategy
for
prevention
or
treatment
fibrosis.
