THE THERAPIST (Journal of Therapies & Rehabilitation Sciences),
Journal Year:
2024,
Volume and Issue:
unknown, P. 02 - 10
Published: Dec. 31, 2024
Parkinson’s
Disease
(PD)
is
a
progressive
neurodegenerative
disorder
that
affects
motor
and
non-motor
functions,
including
cognitive,
emotional
autonomic
systems,
severely
impacting
quality
of
life.
The
symptoms
PD
are
successfully
treated
by
traditional
physiotherapy,
but
such
treatments
often
fail
to
address
the
complexity
variety
PD.
Advancements
in
exercise-based
neuro-physiotherapy
reviewed,
with
focus
on
innovative
multimodal
approaches
combining
cognitive
rehabilitation.
Technology
driven
interventions
like
virtual
reality,
robotics
AI
add
real
time
feedback
personalized
care
therapy,
while
strategies
dual
task
training
mindfulness
practice
impairments.
Comprehensive
benefits
exercise
programs
include
aerobic,
strength
flexibility
exercises
targeted
achieve
both
physical
mental
health.
Comparative
analysis
traditional,
emerging
shows
their
strengths
weaknesses,
highlights
need
for
tailored
interventions.
Future
directions
directed
at
longitudinal
research,
combination
pharmacological
surgical
treatments,
use
biomarkers
design
therapy
enhance
outcomes
life
patients
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
Abstract
Gait
detection
is
essential
for
the
assessment
of
human
health
status
and
early
diagnosis
diseases.
The
current
gait
analysis
systems
are
bulky,
limited
in
scope
use,
cause
interference
with
movement
measured
person.
Hence,
it
necessary
to
develop
a
wearable
system
that
soft,
breathable,
lightweight,
self‐powered.
Here,
plantar
pressure
sensor
array
based
on
flexible
triboelectric
(FTPS)
developed.
Soft,
electrospinning
nanofiber
film
excellent
properties
used
as
sensor,
achieving
high
sensitivity
45.1
mV
kPa
−1
range
40–200
19.4
200–400
kpa.
32
FTPSs
integrated
into
an
intelligent
insole,
which
has
characteristics
easy
production,
good
air
permeability,
long‐time
stability,
no
external
power
supply,
etc.
Based
long
short‐term
memory
artificial
neural
network
deep
learning
model,
accuracy
judgment
can
reach
94.23%.
This
work
provides
feasible
solution
real‐time
detection,
will
have
potential
applications
disease.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1759 - 1759
Published: Feb. 1, 2024
Parkinson’s
disease
(PD)
is
associated
with
various
deficits
in
sensing
and
responding
to
reductions
oxygen
availability
(hypoxia).
Here
we
summarize
the
evidence
pointing
a
central
role
of
hypoxia
PD,
discuss
relation
dependence
pathological
hallmarks
including
mitochondrial
dysfunction,
dopaminergic
vulnerability,
alpha-synuclein-related
pathology,
highlight
link
cellular
systemic
sensing.
We
describe
cases
suggesting
that
may
trigger
Parkinsonian
symptoms
but
also
emphasize
endogenous
systems
protect
from
can
be
harnessed
PD.
Finally,
provide
examples
preclinical
clinical
research
substantiating
this
potential.
AIMS neuroscience,
Journal Year:
2024,
Volume and Issue:
11(2), P. 76 - 102
Published: Jan. 1, 2024
<abstract>
<p>Stress
has
emerged
as
a
prominent
and
multifaceted
health
concern
in
contemporary
society,
manifesting
detrimental
effects
on
individuals'
physical
mental
well-being.
The
ability
to
accurately
predict
stress
levels
real
time
holds
significant
promise
for
facilitating
timely
interventions
personalized
management
strategies.
increasing
incidence
of
stress-related
issues
highlights
the
importance
thoroughly
understanding
prediction
mechanisms.
Given
that
is
contributing
factor
wide
array
problems,
objectively
assessing
crucial
behavioral
physiological
studies.
While
numerous
studies
have
assessed
controlled
environments,
objective
evaluation
everyday
settings
still
needs
be
explored,
primarily
due
contextual
factors
limitations
self-report
adherence.
This
short
review
explored
emerging
field
real-time
prediction,
focusing
utilizing
data
collected
by
wearable
devices.
Stress
was
examined
from
comprehensive
standpoint,
acknowledging
its
both
synthesized
existing
research
development
application
models,
underscoring
advancements,
challenges,
future
directions
this
rapidly
evolving
domain.
Emphasis
placed
examining
critically
evaluating
literature
analysis,
devices
monitoring.
synthesis
findings
aimed
contribute
better
potential
technology
predicting
time,
thereby
informing
design
effective
approaches.</p>
</abstract>
Science Advances,
Journal Year:
2025,
Volume and Issue:
11(7)
Published: Feb. 12, 2025
Parkinson’s
disease
(PD)
is
a
neurodegenerative
disorder
characterized
by
the
progressive
accumulation
of
abnormal
α-synuclein
(α-syn)
within
dopaminergic
neurons
in
substantia
nigra
region
brain.
Despite
excessive
α-syn
being
key
to
pathogenesis
PD,
mechanisms
governing
its
clearance
remain
elusive.
In
this
study,
we
found
that
endosomal
sorting
complex
required
for
transport
(ESCRT)
system
plays
crucial
role
capturing
and
facilitating
degradation
ubiquitinated
α-syn.
The
E3
ubiquitin
ligase
Listerin
was
promote
K27-linked
polyubiquitination
α-syn,
directing
it
endosome
subsequent
degradation.
We
showed
deletion
gene
exacerbates
progression
mouse
model
whereas
overexpression
effectively
mitigates
PD
mice.
Consequently,
our
study
reveals
mechanism
identifies
as
promising
therapeutic
target
treatment
PD.
