Extracellular Vesicles from hiPSC-derived NSCs Protect Human Neurons against Abeta-42 Oligomers Induced Neurodegeneration, Mitochondrial Dysfunction and Tau Phosphorylation

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

One of the hallmarks Alzheimer's disease (AD) is buildup amyloid beta-42 (Aβ-42) in brain, which leads to various adverse effects. Therefore, therapeutic interventions proficient reducing Aβ-42-induced toxicity AD are great interest. promising approach use extracellular vesicles from human induced pluripotent stem cell-derived neural cells (hiPSC-NSC-EVs) because they carry multiple miRNAs and proteins capable protecting neurons against pathological changes. this

Language: Английский

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Citrus supplementation in subjective cognitive decline: results of a 36-week, randomized, placebo-controlled trial

Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 1, 2024

Developing interventions for older adults with subjective cognitive decline (SCD) has the potential to prevent dementia in this at-risk group. Preclinical models indicate that Citrus-derived phytochemicals could benefit cognition and inflammatory processes, but results from clinical trials are still preliminary. The aim of study is determine effects long-term supplementation Citrus peel extract on performance inflammation individuals SCD.

Language: Английский

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Nutraceuticals: a promising, yet unregulated Frontier in Healthcare

European Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Language: Английский

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