Advances in Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 13(04), P. 95 - 116
Published: Jan. 1, 2024
Language: Английский
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102414 - 102414
Published: July 14, 2024
Language: Английский
Citations
14
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 7, 2025
Language: Английский
Citations
1
Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 165, P. 105867 - 105867
Published: Aug. 28, 2024
Neurodegenerative diseases (NDDs) are a series of disorders characterized by the progressive loss specific neurons, leading to cognitive and locomotor impairment. NDDs affect millions patients worldwide but lack effective treatments. Dysregulation lipids, particularly accumulation lipid droplets (LDs), is strongly implicated in pathogenesis NDDs. How LDs contribute occurrence development NDDs, their potential as therapeutic targets remain be addressed. In present review, we first introduce processes formation, transportation degradation. We then highlight how contributes cell type-specific manner. Moreover, discuss currently available methods for detecting elaborate on LDs-based strategies Lastly, identify gaps that need filled better leverage LD-based theranostics other diseases. hope this review could shed light role facilitate novel
Language: Английский
Citations
7
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: May 29, 2024
Alzheimer's and Parkinson's diseases are among the most prevalent neurodegenerative conditions affecting aging populations globally, presenting significant challenges in early diagnosis management. This narrative review explores pivotal role of advanced neuroimaging techniques detecting managing these at stages, potentially slowing their progression through timely interventions. Recent advancements MRI, such as ultra-high-field systems functional have enhanced sensitivity for subtle structural changes. Additionally, development novel amyloid-beta tracers other emerging modalities like optical imaging transcranial ultrasonography improved diagnostic accuracy capability existing methods. highlights clinical applications technologies diseases, where they shown performance, enabling earlier intervention better prognostic outcomes. Moreover, integration artificial intelligence (AI) longitudinal research is a promising enhancement to refine detection strategies further. However, this also addresses technical, ethical, accessibility field, advocating more extensive use overcome barriers. Finally, we emphasize need holistic approach that incorporates both neurological psychiatric perspectives, which crucial optimizing patient care outcomes management diseases.
Language: Английский
Citations
6
Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(9), P. 104101 - 104101
Published: July 16, 2024
Language: Английский
Citations
4
Journal of Neuroscience Methods, Journal Year: 2025, Volume and Issue: 415, P. 110359 - 110359
Published: Jan. 5, 2025
Language: Английский
Citations
0
Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 98 - 108
Published: Jan. 1, 2025
Language: Английский
Citations
0
International Journal of Community Medicine and Public Health, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Physicians face challenges in diagnosing and managing of neuromuscular neurodegenerative diseases, such as amyotrophic lateral sclerosis Huntington’s disease, they are rare, clinically variable, often misdiagnosed by traditional diagnostic methods. To overcome these challenges, multimodality imaging, combining techniques like magnetic resonance imaging (MRI), computed tomography (CT), positron emission (PET), ultrasound, has emerged to provide complementary structural, functional, molecular data. This review discusses the roles diagnosing, monitoring, rare diseases. Structural changes neural connectivity identified MRI, metabolic abnormalities detected PET. Real time evaluation nerve muscle is provided whereas CT aids respiratory function skeletal structures. These methods combined improve accuracy further understanding disease mechanisms. Emerging multimodal techniques, ultra-high-field MRI hybrid PET-MRI systems, being developed greater resolution efficiency. Multimodality a critical tool improving care patients with disorders. However, its widespread use hindered high costs, limited access, need for standardized protocols validation. Future directions include development biomarkers, integration other methods, artificial intelligence analyze complex
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 9, 2025
Chiral nanomaterials are widely investigated over recent decades due to their biocompatibility and unique chiral effects. These key properties have significantly promoted the rapid development of in bioengineering medicine. In this review, basic principles constructing along with latest progress research comprehensively summarized. Then, application for diagnosis neurodegenerative diseases (NDDs) is systematically described. addition, significant potential broad prospects treatment NDDs highlighted from several aspects, including disaggregation neurofibrils, scavenging reactive oxygen species, regulation microbial-gut-brain axis, elimination senescent cells, promotion directed differentiation neural stem cells. Finally, a perspective challenges future provided.
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 532, P. 216527 - 216527
Published: Feb. 18, 2025
Language: Английский
Citations
0