The impact of medication regimen complexity on patient-related and clinical outcomes in kidney failure: a systematic review
Expert Opinion on Pharmacotherapy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 9
Published: Jan. 7, 2025
Introduction
Kidney
failure
is
a
life-limiting
condition
that
profoundly
impacts
an
individual's
quality
of
life.
The
significant
medication
burden
on
patients
required
to
manage
the
comorbidities
and
complications
kidney
can
have
implications
for
patient-reported
clinical
outcomes.
Language: Английский
Medicine Optimisation and Deprescribing Intervention Outcomes for Older People with Dementia or Mild Cognitive Impairment: A Systematic Review
Drugs & Aging,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 11, 2025
Polypharmacy
is
common
amongst
older
people
with
dementia
or
mild
cognitive
impairment
(MCI),
increasing
the
risk
of
medication-related
harm.
Medicine
optimisation
and
deprescribing
to
reduce
polypharmacy
considered
feasible,
safe
can
lead
improved
health.
However,
for
those
living
MCI,
this
be
challenging.
This
systematic
review
aimed
summarise
evidence
on
outcomes
medicine
interventions
MCI.
Literature
was
searched
using
CINAHL,
Embase,
Medline,
PsychINFO,
Web
Science
Cochrane
Library
from
database
inception
January
2024.
Papers
reporting
data
specific
MCI
interventional
research
studies
any
design
in
setting
were
included.
A
narrative
synthesis
conducted
owing
heterogeneity
study
designs
outcomes.
Quality
assessed
Mixed
Methods
Appraisal
Tool.
total
32
papers
28
included,
samples
ranging
29
17,933
patients
a
mean
patient
age
74
88
years.
Of
studies,
60%
undertaken
long-term
care
settings.
Involvement
and/or
carers
limited.
grouped
as
either
incorporating
medication
component
(n
=
13),
education
5)
both
14).
Studies
primarily
focussed
outcomes,
generally
showing
positive
effect
decreasing
number
improving
appropriateness
medications.
Fewer
reported
clinical
(behavioural
psychological
symptoms
dementia,
falls,
quality
life
cognition)
mixed
findings.
reduction
no
change
mortality
hospital
attendance
demonstrated
safety
few
these
The
mixed.
reduced
increased
medications,
although
less
frequently
reported,
seemed
showed
an
absence
worsening
highlights
need
further
research,
particularly
at
home,
more
focus
greater
involvement
informal
carers.
protocol
published
International
Prospective
Register
Systematic
Reviews
(PROSPERO)
[Ref:
CRD42023398139].
Language: Английский
The effect of deprescribing interventions on mortality and health outcomes in older people: An updated systematic review and meta‐analysis
British Journal of Clinical Pharmacology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 20, 2024
Abstract
Aims
Previous
systematic
reviews
suggest
that
deprescribing
may
improve
survival,
particularly
in
frail
older
people.
Evidence
is
rapidly
accumulating,
suggesting
a
need
for
an
updated
review
of
the
literature.
Methods
We
2016
and
meta‐analysis
to
include
studies
published
from
inception
26
April
2024
specified
databases.
Studies
which
people
had
at
least
one
medication
deprescribed
were
included
grouped
by
study
designs
targeted
medications.
The
risk
bias
was
assessed
using
Cochrane
tool
Newcastle‐Ottawa
tool.
Odds
ratios
(OR)
or
mean
differences
calculated
as
effect
measures
either
Mantel–Haenszel
generic
inverse‐variance
method
with
fixed‐
random‐effects
meta‐analyses.
primary
outcome
mortality.
Secondary
outcomes
adverse
drug
withdrawal
events,
physical
health,
cognitive
function,
quality
life
on
regimen.
Subgroup
analyses
performed
based
age
intervention
types.
Results
A
total
259
(reported
286
papers)
this
review.
Deprescribing
polypharmacy
did
not
result
significant
reduction
mortality
both
randomized
(OR
0.96,
95%
confidence
interval
[CI]
0.84–1.09)
non‐randomized
0.70,
CI
0.36–1.38).
Further
subgroup
demonstrated
young
old
(aged
65–79)
0.71,
0.51–0.99)
when
patient‐specific
interventions
applied
0.79,
0.63–0.99).
Conclusions
can
be
achieved
potentially
important
benefits
terms
improved
are
initiated
early
old.
Language: Английский
Deprescribing in DGPPN S3 guidelines—a systematic analysis
Der Nervenarzt,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 17, 2024
Polypharmacotherapy: the Use of Artificial Intelligence to Reduce Risk of Adverse Drug Reactions (Review)
В. В. Береговых,
No information about this author
V I Panteleev,
No information about this author
Nikolay L. Shimanovsky
No information about this author
et al.
Annals of the Russian academy of medical sciences,
Journal Year:
2024,
Volume and Issue:
79(4), P. 346 - 352
Published: Oct. 10, 2024
Artificial
intelligence
(AI)
in
healthcare
can
be
used
to
solve
a
wide
range
of
tasks,
such
as
diagnosis,
treatment
and
self-monitoring
patients.
This
review
is
devoted
the
problem
polypharmacotherapy,
development
adverse
drug
reactions
consequence
it
use
AI
this
field.
allows
analyze
interactions,
identify
possible
suggest
optimal
combinations
drugs
regimen.
The
clinical
decision
support
systems,
which
are
developed
various
countries,
has
shown
improved
efficiency
doctor’s
work
increased
patient’s
safety
with
help
AI.
polypharmacotherapy
requires
further
research
improve
software
products
that
would
allow
evaluating
not
only
paired,
but
also
multiple
interactions.
Language: Английский
Polypharmacy in Older Adults: The Hazard of Hospitalization and Mortality is Mediated by Potentially Inappropriate Prescriptions, Findings From the Moli-sani Study
International Journal of Public Health,
Journal Year:
2024,
Volume and Issue:
69
Published: Oct. 24, 2024
Language: Английский