Editorial: Genetics and epigenetics in ovarian aging

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 11, 2025

begins in a mid-30s, with menopause usually occurring between the 24 ages of 48 and depletion oocyte stock (ovarian aging) being an inevitable process 25 during woman's lifetime, ultimately influencing lifespan health outcomes. Ovarian aging is 26 multidimensional characterized by progressive decline follicle number 27 quality that accelerates around 37 years age, leading to increased infertility congenital 28 disabilities offspring 1

Language: Английский

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A High-resolution N-Glycoproteome Landscape of Aging Mouse Ovary

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103584 - 103584

Published: March 7, 2025

Ovarian aging typically precedes the decline of other organ systems, yet its molecular mechanisms remain poorly understood. Glycosylation as one most important protein modifications has been especially unexplored in this context. Here, we present first high-resolution glycoproteomic landscape mouse ovaries, uncovering site-specific N-glycan signatures across subcellular components such high proportions complex glycans, core fucosylation, and LacdiNAc branches at zone pellucida. We report three major glycosylation alterations aged ovaries: frequently changed core-fucosylation associated with cell adhesion immune responses, decreased glycans on zona pellucida (ZP) responsible for fertility decline, increased sialylated modified by Neu5Ac Neu5Gc playing different roles activation responses. Integrated multi-omic analyses further highlight unique role glycosylation, distinct from phosphorylation, regulating key signaling pathways, antigen processing presentation, complement coagulation cascades, ROS biosynthetic metabolic processes, well death. This study offers a novel glycobiological perspective ovarian aging, broadening our understanding beyond traditional approaches.

Language: Английский

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Pathological and Inflammatory Consequences of Aging

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 404 - 404

Published: March 12, 2025

Aging is a complex, progressive, and irreversible biological process that entails numerous structural functional changes in the organism. These affect all bodily systems, reducing their ability to respond adapt environment. Chronic inflammation one of key factors driving development age-related diseases, ultimately causing substantial decline abilities older individuals. This persistent inflammatory state (commonly known as “inflammaging”) characterized by elevated levels pro-inflammatory cytokines, an increase oxidative stress, perturbation immune homeostasis. Several factors, including cellular senescence, contribute this milieu, thereby amplifying conditions such cardiovascular disease, neurodegeneration, metabolic disorders. Exploring mechanisms chronic aging essential for developing targeted interventions aimed at promoting healthy aging. review explains strong connection between inflammation, highlighting potential therapeutic approaches like pharmacological treatments, dietary strategies, lifestyle changes.

Language: Английский

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Multi-omics approaches for biomarker discovery and precision diagnosis of prediabetes

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

Recent advancements in multi-omics technologies have provided unprecedented opportunities to identify biomarkers associated with prediabetes, offering novel insights into its diagnosis and management. This review synthesizes the latest findings on prediabetes from multiple omics domains, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, radiomics. We explore how these elucidate molecular cellular mechanisms underlying analyze potential predictive value disease progression. Integrating data helps address limitations of traditional diagnostic methods, enabling early detection, personalized interventions, improved patient outcomes. However, challenges such as integration, standardization, clinical validation translation remain be resolved. Future research leveraging artificial intelligence machine learning is expected further enhance power technologies, contributing precision tailored management prediabetes.

Language: Английский

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Metabolomics and transcriptomics analyses reveal the complex molecular mechanisms by which the hypothalamus regulates sexual development in female goats

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 28, 2025

The hypothalamus is a critical organ that regulates sexual development in animals. However, current research on the hypothalamic regulation of maturation female goats remains limited. In this study, we conducted metabolomic and transcriptomic analyses tissues Jining grey at different stages (1 day old (neonatal, D1, n = 5), 2 months (prepuberty, M2, 4 (sexual maturity, M4, 6 (breeding period, M6, 5)). A total 418 differential metabolites (DAMs) were identified among which abundance such as anserine, L-histidine, carnosine, taurine, 4-aminobutyric gradually increased with progression development. These may regulate neuronal hormone secretion processes by influencing metabolism histidine phenylalanine. Through combined analyses, differentially expressed genes mitogen-activated protein kinase 9 (MAP3K9), prune homolog BCH domain (PRUNE2), potassium voltage-gated channel interacting 4(KCNIP4) jointly energy Gonadotropin-releasing neurons conjunction DAMs, including LPC22:5, 2-Arachidonyl Glycerol ether, LPE22:5, Lysops22:5. Additionally, elucidated molecular mechanism through glutathione goats. summary, study illustrates dynamic changes mRNA within tissue during postnatal This provide significant scientific insights for future animal breeding.

Language: Английский

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Role of mitochondrial homeostasis in female reproductive system aging

Science Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Exploring the causal association between epigenetic clocks and menopause age: insights from a bidirectional Mendelian randomization study

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 23, 2024

Background Evidence suggests a connection between DNA methylation (DNAm) aging and reproductive aging. However, the causal relationship DNAm age at menopause remains uncertain. Methods Employing established epigenetic clocks, such as Hannum acceleration (Hannum), Intrinsic (IEAA), DNAm-estimated granulocyte proportions (Gran), GrimAge (GrimAgeAccel), PhenoAge (PhenoAgeAccel), plasminogen activator inhibitor-1 levels (DNAmPAIadjAge), bidirectional Mendelian randomization (MR) study was carried out to explore potential causality menopausal age. The primary analytical method used inverse variance weighted (IVW) estimation model, supplemented by various other techniques. Results or deceleration, indicated Hannum, IEAA, Gran, GrimAgeAccel, PhenoAgeAccel, DNAmPAIadjAge, did not exhibit statistically significant effect on according forward MR analysis. there suggestive positive association Gran (Beta = 0.0010; 95% confidence interval (CI): 0.0004, 0.0020) in reverse Conclusion observed increase relation could potentially serve valuable indicator for evaluating physiological status onset of menopause.

Language: Английский

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Nur77 improves ovarian function in reproductive aging mice by activating mitophagy and inhibiting apoptosis

Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 23, 2024

Abstract Reproductive aging not only affects the fertility and physical mental health of women but also accelerates process other organs. There is an urgent need newfor novel mechanisms, targets, drugs to break vicious cycle mitochondrial dysfunction, redox imbalance, germ cell apoptosis associated with ovarian aging. Autophagy, recognized as a longevity mechanism, has recently become focal point in anti-aging research. Although mitophagy type autophagy, its role regulatory mechanisms aging, particularly age-related function decline, remain unclear. Nerve growth factor inducible gene B (Nur77) early response that can be stimulated by oxidative stress, DNA damage, metabolism, inflammation. Recent evidence recommends decreased expression Nur77 myocardial fibrosis, renal Parkinson's disease; however, association been studied yet. We herein identified regulator senescence, apoptosis, found overexpression activate mitophagy, improve reduce ultimately enhance reserve aged mice ovaries. Furthermore, we discovered between AKT pathway through String molecular docking analyses. Experimental confirmation revealed AKT/mTOR signaling involved regulation function. In conclusion, our results suggest promising target for preventing treating decline related reproductive

Language: Английский

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Age-related uterine changes and its association with poor reproductive outcomes: a systematic review and meta-analysis

Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 30, 2024

The decline in women's fertility becomes clinically relevant between 35–40 years old, when there is insufficient ovarian activity, and it more difficult to achieve pregnancy naturally through artificial reproductive technologies. A competent endometrium required for establishing maintaining a term, however, experts the field underestimate contribution of endometrial age its impact on outcomes remains unclear. systematic search full-text articles available PubMed was conducted retrieve studies published until March 2023. Search terms included: endometrium, uterus, age, aging, pregnancy, oocyte donation. Terms related pathologies were excluded. Eligibility criteria included original, rigorous, accessible peer-reviewed work, English effect uterus endometrium. From 11,354 records identified, 142 review, 59 eligible meta-analysis thickness (n = 7), rate 22), implantation 10), live birth 10) loss 11). Studies only transfers embryos from ovum donation (ovum donors < 36 old). Age shrinks uterus; depletes blood supply narrow uterine veins progressive spiral arteries; disrupts architecture cellular composition; alters hormone production, shortening menstrual cycle length impeding progression secretory stage; dysregulates key functions such as adhesion, proliferation, apoptosis, receptivity, among others. Women over old had significantly thinner (MD 0.52 mm). Advanced maternal associated with lower odds achieving (27%) clinical (20%), or higher experiencing (44%). Due reported this managing patients advanced may require considering factor potential tissue treat anti-aging strategies. This review provides researchers clinicians an updated in-depth summary topic, encouraging development new tailored preventive strategies precision medicine infertility. PROSPERO 2023 (CRD42023416947).

Language: Английский

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Kinderwunsch nach Vasektomie

Deleted Journal, Journal Year: 2024, Volume and Issue: 63(11), P. 1111 - 1121

Published: Oct. 16, 2024

The vasectomy is a safe and effective method of contraception for men. Up to 6% men who underwent have renewed child wish. Microsurgical reversal (VR) in men, microsurgical epididymal sperm aspiration (MESA), or testicular extraction (TESE) plus assisted reproductive technology (ART) the female partner as well combination VR MESA/TESE ART represent established therapeutic strategies. Various factors may impact success VR, defined by patency pregnancy rate following including partner's age, obstructive interval, surgical technique. There no difference live birth ART. However, ART, time shorter compared with VR. Overall, more cost-effective than allows lower burden, especially partner. In addition, combined TESE plus-if necessary-ART alone, even partners advanced age. For successful counseling regarding different therapy options wish after vasectomy, it important evaluate underlying individual situation couple.

Language: Английский

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