Associations between stroke and vascular dementia combing Mendelian randomization with network pharmacology

Medicine, Journal Year: 2025, Volume and Issue: 104(8), P. e41686 - e41686

Published: Feb. 21, 2025

Background: Stroke and vascular dementia (VaD) are major causes of death disability worldwide, there is a complex interplay between them. In this study, we applied the method Mendelian randomization (MR) network pharmacology to uncover elucidate these mechanisms. Methods: We employed single nucleotide polymorphisms that exhibit strong associations with stroke VaD as instrumental variables for MR analysis. Our bidirectional analyses were conducted using 3 robust methods: inverse variance weighting, weighted median, Weighted mode MR-Egger regression. Additionally, performed sensitivity assess heterogeneity, sensitivity, stability levels. Furthermore, curated screened targets relevant subsequently carried out gene ontology KEGG pathway enrichment analyses. Finally, approaches utilized explore potential mechanisms underlying VaD. Results: The results analysis demonstrate significant positive causal relationship (OR = 2.06, 95% confidence interval [CI] 1.17–3.61, P .01). Conversely, no evidence suggests increases risk stroke. Network reveals total 222 common shared by both conditions, particular emphasis on peptide tyrosine phosphorylation pathways, including those associated resistance EGFR kinase inhibitors AGE-RAGE signaling pathway. Conclusions: based available summary statistics from genome-wide association studies support may contribute through phosphorylation-related biological processes.

Language: Английский

The role of obesity in increasing the risk of hypertension in the elderly

Jurnal Edukasi Ilmiah Kesehatan, Journal Year: 2024, Volume and Issue: 2(3), P. 86 - 93

Published: Nov. 22, 2024

Introduction: Obesity has been identified as one of the main risk factors contributing to increase in hypertension cases, particularly among elderly. This study aims analyze role obesity increasing elderly by examining relationship between body mass index (BMI) and blood pressure. Methods: research uses a cross-sectional design, an analytical that studies causes incidents or incidents. Data collection questionnaire. The sample this was 64 hypertensive patients working data analysis using chi-square test. Results: study's results indicate (p=0.000) incidence working. showed with obese status had significantly higher compared average weight. Conclusions: These findings underscore importance preventing treating reduce other health complications. is expected contribute formulating policies prevention programs through practical weight management approach

Language: Английский