Clinical Epigenetics,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Nov. 19, 2024
In
recent
years,
epigenetic
modifications
have
been
strongly
linked
to
tumor
development,
with
histone
representing
a
key
mechanism.
addition,
non-coding
RNAs
(ncRNAs)
play
critical
role
in
regulating
cancer-related
pathways.
The
abnormal
interaction
between
and
ncRNAs,
both
pivotal
regulators,
has
widely
observed
across
various
cancer
types.
Here,
we
systematically
explore
the
molecular
mechanisms
through
which
ncRNAs
contribute
pathogenesis
of
digestive
system
cancers,
aberrant
ncRNA-mediated
manipulate
biological
behaviors
cells
including
proliferation,
migration,
angiogenesis,
etc.
provide
new
insights
into
diagnostic,
prognostic
markers,
therapeutic
targets
chemoradiation
resistance
for
cancers
from
perspective.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(9), P. 1062 - 1062
Published: Aug. 30, 2024
Neurodegenerative
diseases
encompass
a
spectrum
of
disorders
marked
by
the
progressive
degeneration
structure
and
function
nervous
system.
These
conditions,
including
Parkinson's
disease
(PD),
Alzheimer's
(AD),
Huntington's
(HD),
Amyotrophic
lateral
sclerosis
(ALS),
Multiple
(MS),
often
lead
to
severe
cognitive
motor
deficits.
A
critical
component
neurodegenerative
pathologies
is
imbalance
between
pro-oxidant
antioxidant
mechanisms,
culminating
in
oxidative
stress.
The
brain's
high
oxygen
consumption
lipid-rich
environment
make
it
particularly
vulnerable
damage.
Pro-oxidants
such
as
reactive
nitrogen
species
(RNS)
(ROS)
are
continuously
generated
during
normal
metabolism,
counteracted
enzymatic
non-enzymatic
defenses.
In
diseases,
this
balance
disrupted,
leading
neuronal
This
systematic
review
explores
roles
stress,
gut
microbiota,
epigenetic
modifications
aiming
elucidate
interplay
these
factors
identify
potential
therapeutic
strategies.
We
conducted
comprehensive
search
articles
published
2024
across
major
databases,
focusing
on
studies
examining
relationships
redox
homeostasis,
changes
neurodegeneration.
total
161
were
included,
comprising
clinical
trials,
observational
studies,
experimental
research.
Our
findings
reveal
that
stress
plays
central
role
pathogenesis
with
microbiota
composition
significantly
influencing
balance.
Specific
bacterial
taxa
markers
identified
modulators
suggesting
novel
avenues
for
intervention.
Moreover,
recent
evidence
from
human
animal
supports
emerging
concept
targeting
homeostasis
through
therapies.
Future
research
should
focus
validating
targets
settings
exploring
personalized
medicine
strategies
based
individual
profiles.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 13, 2024
Autoimmune
diseases
comprise
a
large
group
of
conditions
characterized
by
complex
pathogenesis
and
significant
heterogeneity
in
their
clinical
manifestations.
Advances
sequencing
technology
have
revealed
that
addition
to
genetic
susceptibility,
various
epigenetic
mechanisms
including
DNA
methylation
histone
modification
play
critical
roles
disease
development.
The
emerging
field
epigenetics
has
provided
new
perspectives
on
the
development
autoimmune
diseases.
Aberrant
modifications
can
be
used
as
biomarkers
for
diagnosis
prognosis.
Exploration
human
profiles
patients
with
exhibit
markedly
altered
compared
healthy
individuals.
Targeted
cutting-edge
therapies
are
emerging.
For
example,
inhibitors
rectify
dysregulation
relieve
patients.
Histone
deacetylase
such
vorinostat
affect
chromatin
accessibility
further
regulate
gene
expression,
been
treating
hematological
malignancies.
Epigenetic
opened
avenues
precise
treatment
offer
opportunities
improved
therapeutic
outcomes.
Our
review
aid
comprehensively
elucidation
targeted
ultimately
benefit
these
conditions.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
Background
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
chronic,
progressive,
fibrosing
interstitial
pneumonia
of
unknown
etiology.
Abnormal
regulation
the
cytoskeleton
key
factor
driving
fibrogenesis.
However,
molecular
mechanisms
remodeling
in
remains
obscure.
Methods
Succinylome
analysis
lung
tissues
from
bleomycin
(BLM)-treated
mice
was
performed.
Key
modified
proteins
and
sites
were
identified
through
Clusters
Orthologous
Groups
(COG)
functional
classification
statistics
liquid
chromatograph-mass
spectrometer
(LC-MS/MS)
analysis.
F-actin-capping
protein
subunit
beta
(CAPZB)
selected
for
further
investigation.
Gain-
loss-of-function
site
mutation
studies
conducted
to
assess
function
CAPZB
effect
succinylation
on
it.
Then,
Co-immunoprecipitation
(Co-IP)
used
identify
desuccinylase
CAPZB.
Finally,
adenoviral
vectors
constructed
evaluate
vivo.
Results
A
total
910
lysine
388
differentially
expressed
between
BLM-treated
sham
group.
COG
showed
that
42
classified
into
cytoskeleton-related
proteins.
Among
these
proteins,
level
significantly
decreased.
And
lysine57
(K57),
lysine95
(K95),
lysine235
(K235)
as
desuccinylation
fibrosis.
revealed
restrained
cytoskeletal
inhibit
The
modification
inhibited
its
capping
barbed
end
F-actin,
resulting
promote
fibroblast
proliferation,
migration,
differentiation.
Further,
histone
deacetylase
enzymes
(HDACs)
inhibitors
Co-IP
demonstrated
HDAC8
Overexpressed
desuccinylated
CAPZB,
led
abnormal
F-actin
polymerization
promoted
therapeutic
succinylated
confirmed
mice.
Conclusions
Collectively,
our
research
HDAC8-mediated
idiopathic
by
enhancing
remodeling,
suggesting
could
be
potential
target
related
Epigenetics & Chromatin,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: March 21, 2025
The
origins
of
many
diseases
can
be
traced
to
the
dynamic
interplay
genetic
predispositions
and
environmental
exposures
post-birth.
Epigenetic
modifications
have
recently
gained
prominence
as
a
significant
mediator
between
information
factors,
influencing
occurrence
progression
disease.
There
is
burgeoning
body
evidence
supports
that
physical
exercise,
acting
an
external
stimulus,
exerts
discernible
impact
on
major
epigenetic
modifications,
including
histone
DNA
methylation,
RNA
non-coding
RNA.
This
effect
assumes
pivotal
role
in
pathogenesis
various
human
diseases.
Exploring
molecular
mechanisms
through
which
exercise
enhances
health
holds
promise
deepening
our
understanding
how
it
improves
physiological
functions,
mitigates
disease
risks,
establishes
theoretical
foundation
for
employing
non-pharmacological
intervention
prevention
treatment.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 28, 2025
Ischemic
stroke
(IS)
remains
a
leading
cause
of
mortality
and
disability
worldwide,
driven
by
genetic
predispositions
environmental
interactions,
with
epigenetics
playing
pivotal
role
in
mediating
these
processes.
Specific
modifying
enzymes
that
regulate
epigenetic
changes
have
emerged
as
promising
targets
for
IS
treatment.
DNA
methyltransferases
(DNMTs),
ten-eleven
translocation
(TET)
dioxygenases,
histone
acetyltransferases
(HATs),
deacetylases
(HDACs)
are
central
to
regulation.
These
maintain
dynamic
balance
between
methylation/demethylation
acetylation/deacetylation,
which
critically
influences
gene
expression
neuronal
survival
IS.
This
review
is
based
on
both
vivo
vitro
experimental
studies,
exploring
the
roles
DNMT/TET
HAT/HDAC
IS,
evaluating
their
potential
therapeutic
targets,
discussing
use
natural
compounds
modulators
develop
novel
treatment
strategies.
