Neuronal heterogeneity in the medial septum and diagonal band of Broca: classes and continua DOI Creative Commons
F. E. Kuhn, Petra Mocellin,

Stéfano Pupe

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

SUMMARY The medial septum and diagonal band of Broca (MSDB) is known for its diverse populations cholinergic, GABAergic, glutamatergic neurons, each contributing to various cognitive processes. However, cell-specific manipulations within this region often result in incongruous behavioral outcomes reach conflicting conclusions, likely because a hitherto unknown molecular complexity cellular landscape. In study, we employed single-cell RNA sequencing thoroughly describe the heterogeneity MSDB neurons. We confirmed previously established neuronal classes, found gene expression gradients them revealed genetically defined subclusters. Moreover, characterized genetic profiles these subclusters mapped their spatial distribution. Our analysis presents comprehensive description provides marker genes target them, explains previous paradoxical results, opens unexplored avenues study impact neuromodulators basal forebrain.

Language: Английский

Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice DOI Creative Commons

Gaifen Li,

Qiong Wu, Chao Wang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 7, 2025

Following prolonged exposure to hypoxic conditions, for example, due ascent high altitude, aging or stroke, cognitive deficits can develop. The exact nature and genesis of hypoxia-induced remain unresolved. Curcumin has been reported stimulate neurogenesis reduce neuronal degeneration. This study aimed investigate the effect curcumin on in hypoxic-brain injury mice its potential mechanism. Eight-week-old male C57BL/6J were normobaric-hypoxia (13%O2) 14 days establish models. Morris water maze novel object recognition used detect function each mouse. Immunofluorescence assays, including Fluoro-Jade C (FJC) bromodeoxyuridine (BrdU), degeneration neurogenesis. Thy1-YFP transgenic synapse plasticity. Our results showed that administration rescued impaired cognition mice, shown as enhanced BrdU+ dendritic spine hippocampus. At molecular level, was found promote expression brain-derived neurotrophic factor (BDNF) postsynaptic density protein 95 (PSD95). primary hippocampal neuron detection could growth. In conclusion, our indicates curcumin, increased BDNF PSD95 contacted with interneurons, salvaged interneurons may normalize ambient neuroplasticity, resulting preservation processes well contributing improve performance.

Language: Английский

Citations

1
Shared Molecular Signature in Alzheimer's Disease and Schizophrenia: A Systematic Review of the Reelin Signaling Pathway DOI Creative Commons

Ana Isabel Valderrama-Mantilla,

Celia Martín-Cuevas, Ana Gómez-Garrido

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 169, P. 106032 - 106032

Published: Jan. 31, 2025

Language: Английский

Citations

0
Biomarkers in glioblastoma and degenerative CNS diseases: defining new advances in clinical usefulness and therapeutic molecular target DOI Creative Commons
Fan Bu, Jian Zhong, Ruiqian Guan

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: March 18, 2025

Discovering biomarkers is central to the research and treatment of degenerative nervous system (CNS) diseases, playing a crucial role in early diagnosis, disease monitoring, development new treatments, particularly for challenging conditions like CNS diseases glioblastoma (GBM). This study analyzed gene expression data from public database, employing differential analyses Gene Co-expression Network Analysis (WGCNA) identify modules associated with GBM. Machine learning methods, including Random Forest, Least Absolute Shrinkage Selection Operator (LASSO), Support Vector - Recursive Feature Elimination (SVM-RFE), were used case-control differentiation, complemented by functional enrichment analysis external validation key genes. Ninety-five commonly altered genes related GBM identified, RELN GSTO2 emerging as significant through machine screening. Receiver operating characteristic (ROC) confirmed their diagnostic value, which was further validated externally, indicating elevated controls. The study's integration WGCNA uncovered potential GBM, suggesting utility diagnostics therapeutic targets. contributes perspectives on pathogenesis these complex conditions.

Language: Английский

Citations

0
The Role of Genetic, Environmental, and Dietary Factors in Alzheimer’s Disease: A Narrative Review DOI Open Access
Beyza Mertaş, İffet İpek Boşgelmez

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1222 - 1222

Published: Jan. 30, 2025

Alzheimer’s disease (AD) is one of the most common and severe forms dementia neurodegenerative disease. As life expectancy increases in line with developments medicine, elderly population projected to increase next few decades; therefore, an prevalence some diseases, such as AD, also expected. a result, until radical treatment becomes available, AD expected be more frequently recorded top causes death worldwide. Given current lack cure for only treatments available being ones that alleviate major symptoms, identification contributing factors influence incidence crucial. In this context, genetic and/or epigenetic factors, mainly environmental, disease-related, dietary, or combinations/interactions these are assessed. review, we conducted literature search focusing on environmental air pollution, toxic elements, pesticides, infectious agents, well dietary including various diets, vitamin D deficiency, social (e.g., tobacco alcohol use), variables affected by both behavior gut microbiota. We evaluated studies beneficial effects antibiotics Mediterranean-DASH Intervention Neurodegenerative Delay (MIND) Mediterranean diets.

Language: Английский

Citations

0
Radiomics features of FDG PET images predict ApoE4 DOI Creative Commons
Ramin Rasi, Albert Güveniş

Published: Feb. 1, 2025

Language: Английский

Citations

0
Discovery of novel butyrylcholinesterase inhibitors for treating Alzheimer’s disease DOI Creative Commons
Zhipei Sang, Shuheng Huang,

Wanying Tan

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Neuronal heterogeneity in the medial septum and diagonal band of Broca: classes and continua DOI Creative Commons
F. E. Kuhn, Petra Mocellin,

Stéfano Pupe

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

SUMMARY The medial septum and diagonal band of Broca (MSDB) is known for its diverse populations cholinergic, GABAergic, glutamatergic neurons, each contributing to various cognitive processes. However, cell-specific manipulations within this region often result in incongruous behavioral outcomes reach conflicting conclusions, likely because a hitherto unknown molecular complexity cellular landscape. In study, we employed single-cell RNA sequencing thoroughly describe the heterogeneity MSDB neurons. We confirmed previously established neuronal classes, found gene expression gradients them revealed genetically defined subclusters. Moreover, characterized genetic profiles these subclusters mapped their spatial distribution. Our analysis presents comprehensive description provides marker genes target them, explains previous paradoxical results, opens unexplored avenues study impact neuromodulators basal forebrain.

Language: Английский

Citations

0