Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

The Lancet, Journal Year: 2024, Volume and Issue: 404(10452), P. 572 - 628

Published: July 31, 2024

Language: Английский

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Associations of modifiable dementia risk factors with dementia and cognitive decline: evidence from three prospective cohorts

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 15, 2025

This study aims to assess the relationship between modifiable dementia risk factors and both cognitive decline. Data were obtained from Health Retirement Study (HRS) [2008-2020], China Longitudinal (CHARLS) [2011-2020], English of Ageing (ELSA) [2010-2020]. After adjusting for confounding factors, multivariable logistic regression was utilized analyze dementia, while linear employed examine these Additionally, Cox proportional hazards model used number factor events, clusters, risk. A total 30,113 participants HRS, CHARLS, ELSA included (44.6% male, mean age 66.04 years), with an average follow-up period 7.29 years. low education level significantly associated increased accelerated decline (Overall, OR = 2.93, 95% CI: 2.70-3.18; Overall, β -0.25, -0.60 to-0.55). The presence multiple correlated a higher risk; Specifically, compared more than 5 having no only one lower HR 0.15, 0.11-0.22, 0.22, 0.18-0.25). Compared group coexistence clusters excessive alcohol, diabetes, vision loss, hearing loss (HR 4.11; CI 3.42-4.95; p < 0.001); smoking, 5.18; 4.30-6.23; obesity, smoking 5.96; 5.11-6.95; 0.001) most strongly Among 11 educational attainment has greatest impact on dose-response exists events is risk, associations vary by cluster.

Language: Английский

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Hearing loss and cognitive decline in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) during eight years of follow-up

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Background Hearing loss (HL) of moderate or higher grades is common in older adults with increasing prevalence as people age, rising from 12% at the age 60 years to over 58% 90 years. HL midlife one main potentially modifiable risk factors for dementia. It estimated that 7% dementia cases globally could be avoided if this factor was eliminated. However, much research conducted has been high-income countries even though low- and middle-income have highest Objective To study association between cognitive decline during eight follow-up a Brazilian sample. Methods Participants São Paulo center Longitudinal Study Adult Health were evaluated three waves (2008–10, 2012–14, 2017–19). defined pure-tone audiometry above 25 dB better ear. Cognitive performance six tests related memory, verbal fluency, trail-making tests. A global z-score derived these The linear mixed-effects models adjusted sociodemographic, lifestyle, clinical factors. Results Of 805 participants (mean 51 ± 9 years, 52% women, 60% White), 62 had HL. During follow-up, associated faster (β = −0.012, 95% CI −0.023; 0.000, p 0.039). Conclusions significantly rate after median sample country.

Language: Английский

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Reflections on The Lancet's Commission on dementia prevention, intervention, and care – Authors' reply

The Lancet, Journal Year: 2025, Volume and Issue: 405(10479), P. 625 - 626

Published: Feb. 1, 2025

Language: Английский

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Joint association of sleep duration and depression with new-onset hearing loss: a national cohort study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 14, 2025

Hearing loss, a global health burden, is closely associated with depression and sleep disorders. However, the combined effects of duration on hearing loss risk remain unclear. Data from China Health Retirement Longitudinal Study (CHARLS) were analyzed, including 6,374 adults aged 45 older. Cox proportional hazards models assessed relationship between depression, duration, loss. Mediation analysis explored potential mediating roles CESD-10 score new-onset Subgroup analyses by age, sex, BMI also conducted. Over 7-year follow-up, 1,422 participants developed Both short high scores independently increased Participants long but had ratio (HR) 1.59 (95% CI: 1.35, 1.87) for showed that mediated 10.1% association while 70.8% This study highlights significant interconnected in development Interventions addressing both may offer more effective strategies preventing managing

Language: Английский

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Cochlear Implantation Is Associated With Reduced Incidence of Dementia in Severe Hearing Loss

Ear and Hearing, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Objectives: Hearing loss is recognized as a potentially modifiable risk factor for dementia in midlife. This study aimed to investigate the association between rehabilitation methods and patients with severe profound hearing loss. Design: Using nationwide population data from South Korea, individuals were identified. Individuals aged 40 79 then divided into 3 groups according type of auditory they received period 2005 2010, namely cochlear implant (CI), aid (HA), or no (NR). No (NHL) group (with normal hearing) consisted without Dementia incidence was followed up 2022. Results: The involved 649 CI group, 35,076 HA, 16,494 NR, 1,280,788 NHL group. that (HA groups) had significantly reduced compared NR showing most pronounced reduction. demonstrated lower than HA similar Conclusions: In loss, rates users users. Moreover, those undergoing surgery comparable hearing.

Language: Английский

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A Non-Randomized Pilot Trial of Brain-WISE: A Group-Based Program for Brain Health and Dementia Risk Reduction in Community Settings

Journal of Geriatric Psychiatry and Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

Background Addressing modifiable risk factors can potentially prevent 45% of cases dementia. Here, we present the development Brain-WISE, a low-intensity, group-based intervention to improve brain health in community settings. We conducted preliminary testing refine materials and procedures, assess acceptability adherence, evaluate effects. Methods 143 community-dwelling adults aged 56-93 completed non-randomized pilot trial. The 6-session included psychoeducation, discussion/activities, screenings. Adherence was measured by attendance with questionnaires. Brain knowledge motivation were assessed before after program. Results Across 6 cohorts, 80% - 97% 96% participants agreed that program worthwhile. Knowledge (d = 0.83, P < .001) 0.43, increased significantly. Conclusions Brain-WISE displayed good adherence evidence an effect on motivation. Further is warranted.

Language: Английский

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Modifiable risk factors for dementia

Neurologie pro praxi, Journal Year: 2025, Volume and Issue: 26(2), P. 163 - 168

Published: May 5, 2025

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Exploring the association between hearing status and suicidal ideation among U.S. adults: An observational study

General Hospital Psychiatry, Journal Year: 2024, Volume and Issue: 92, P. 52 - 59

Published: Dec. 22, 2024

Language: Английский

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Development and verification of a machine learning-driven predictive model for cognitive impairment in Age-related Hearing Loss

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 10, 2024

Objective: The objective is to utilize machine learning algorithms create a predictive model for cognitive impairment in age-relate hearing loss. Methods:For this study, we gathered demographic information, conducted audiometric examinations, assessed abilities, and performed blood biochemical tests using data from NHANES. We then identified patients who fit the criteria based on NHANES criteria. The LASSO regression method was employed identify determinants of age-related Additionally, five different were utilized develop population. Data clinical trials between January 2024 May externally validate model's dependability. Results:The study comprised total 521 elderly adults with loss, out which 140 (26.8%) had impairment. used filter factors: education level, alkaline phosphatase, globulin, creatinine, eosinophil percentage. All these predictors included approach training model.The XGB exhibited consistent performance both set (AUC=0.881) test (AUC=0.868), while also demonstrating moderate level discrimination (AUC=0.706). Conclusion:This successfully developed loss learning. demonstrates satisfactory reliability validity across several datasets. utilization models can serve as potent instrument healthcare providers detecting senior population at an early stage.

Language: Английский

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