Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102577 - 102577
Published: Nov. 10, 2024
Language: Английский
The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 970, P. 179032 - 179032
Published: March 1, 2025
Language: Английский
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Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)
Published: March 5, 2025
Language: Английский
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International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2491 - 2491
Published: March 11, 2025
Exosomes, which are nano-sized natural vesicles secreted by cells, crucial for intercellular communication and interactions, playing a significant role in various physiological pathological processes. Their characteristics, such as low toxicity immunogenicity, high biocompatibility, remarkable drug delivery capabilities—particularly their capacity to traverse the blood–brain barrier—make exosomes highly promising vehicles administration treatment of brain disorders. This review provides comprehensive overview exosome biogenesis isolation techniques, strategies loading functionalization exosomes, exosome-mediated barrier penetration mechanisms, with particular emphasis on recent advances exosome-based Finally, we address opportunities challenges associated utilizing system brain, summarizing barriers clinical translation proposing future research directions.
Language: Английский
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Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Abstract Neurodegenerative diseases (NDs) like Alzheimer’s, Parkinson’s, and ALS rank among the most challenging global health issues, marked by substantial obstacles in early diagnosis effective treatment. Current diagnostic techniques frequently demonstrate inadequate sensitivity specificity, whilst conventional treatment strategies encounter challenges related to restricted bioavailability insufficient blood–brain barrier (BBB) permeability. Recently, exosomes—nanoscale vesicles packed with proteins, RNAs, lipids—have emerged as promising agents potential reshape therapeutic approaches these diseases. Unlike drug carriers, they naturally traverse BBB can deliver bioactive molecules affected neural cells. Their molecular cargo influence cell signaling, reduce neuroinflammation, potentially slow neurodegenerative progression. Moreover, exosomes serve non-invasive biomarkers, enabling precise while allowing real-time disease monitoring. Additionally, engineered exosomes, loaded molecules, enhance this capability targeting diseased neurons overcoming barriers. By offering enhanced reduced immunogenicity, an ability bypass physiological limitations, exosome-based present a transformative advantage over existing approaches. This review examines multifaceted role of NDDs, emphasizing their capabilities, intrinsic functions, advanced vehicles.
Language: Английский
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Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 360 - 360
Published: March 19, 2025
Oxidative stress plays an essential role in neurodegenerative pathophysiology, acting as both a critical signaling mediator and driver of neuronal damage. Hydrogen sulfide (H2S), versatile gasotransmitter, exhibits similarly “Janus-faced” nature, potent antioxidant cytoprotective molecule at physiological concentrations, but becoming detrimental when dysregulated. This review explores the dual roles oxidative H2S normal cellular physiology focusing on disease progression. We highlight potential therapeutic opportunities for targeting redox sulfur-based systems diseases by elucidating intricate balance between these opposing forces.
Language: Английский
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Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 19, 2025
Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s are on the rise pose significant challenges due to lack of effective treatments. This review critically examines neuroprotective effects various natural products derived from plants, marine organisms, fungi. Natural have long been used in traditional medicine gaining attention modern drug discovery for their unique properties. The explains how these can protect neurons by influencing key biological pathways involved neurodegeneration. It discusses mechanisms including antioxidant effects, anti-inflammatory actions, modulation cellular signalling, support mitochondrial function. A systematic literature search was conducted minimize bias ensure rigorous study selection. Preclinical studies using animal models cell cultures show that secondary metabolites like polyphenols, alkaloids, terpenoids significantly reduce neuronal damage. Some clinical trials shown promising results. However, bioavailability, standardization, dosage must be addressed translate findings into practice. also evaluates potential synergy combining with conventional treatments, offering a complementary therapeutic approach. represent avenue developing innovative treatments neurodegenerative diseases. highlights research gaps proposes future directions. Future should focus overcoming existing refining improve efficacy safety settings. application knowledge has enhance quality life individuals affected
Language: Английский
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Neuroscience, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
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Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
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Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13
Published: April 3, 2025
Neurodegenerative diseases (NDs) are intricately linked to the accumulation of various neurotoxins, mainly including toxic proteins, inflammatory mediators, excess metal ions, and viral pathogens. Biological neutralization strategies that use agents competitively bind harmful substances thus inhibit their pathogenic activity hold promise for direct removal neurotoxins but face many limitations challenges in NDs. Nanomaterials provide a potential solution neurotoxin NDs due unique physicochemical biological properties. This review summarizes recent advancements nanomaterial-based approaches NDs, highlighting diverse design principles mechanisms action. We also discuss critical role targeted delivery optimize efficiency advantages combining different or introducing other therapeutic components exert synergistic effects. Furthermore, we reveal current future research directions aimed at paving way nanomedicine development based on treatment
Language: Английский
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Journal of Neuropathology & Experimental Neurology, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Recent research indicates that mesenchymal stem cells (MSCs) can transdifferentiate into neuron-like under specific conditions, offering promise for neuronal regeneration. However, challenges remain in optimizing differentiation protocols to generate neuron types. This study explores the impact of supplementing induction media with dopamine and vitamin E guide MSCs toward subtypes. Human adipose-MSCs were utilized investigate differentiation. The cultured supplemented 2 concentrations (2.5 5 µM) (12.5 25 µM). Immunostaining western blot analysis employed assess sequential expression markers associated various stages maturation development. These included Nestin, MAP2, NeuN, TBR1, SATB2, DAT, DBH, CHAT. results demonstrate, first time, significantly enhances accelerates cells. Furthermore, findings suggest induced are predominantly reprogrammed a cholinergic lineage. For MSCs, our reveals addition reprograms mainly neurons, suggesting promising approaches treating neurodegenerative disorders.
Language: Английский
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0