The Emerging Roles of Vacuolar-Type ATPase-Dependent Lysosomal Acidification in Cardiovascular Disease DOI Creative Commons
Yanyan Chen, Caixia Liu,

Hai‐Xin Liu

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 525 - 525

Published: April 3, 2025

The vacuolar-type ATPase (V-ATPase) is a multi-subunit enzyme complex that maintains lysosomal acidification, critical process for cellular homeostasis. By controlling the pH within lysosomes, V-ATPase contributes to overall homeostasis, helping maintain balance between degradation and synthesis of components. Dysfunction impairs leading accumulation undigested materials contributing various diseases, including cardiovascular diseases (CVDs) like atherosclerosis myocardial disease. Furthermore, V-ATPase’s role in function suggests potential therapeutic strategies targeting this mitigate disease progression. Understanding mechanisms by which influences pathology essential developing novel treatments aimed at improving outcomes patients with heart vascular diseases.

Language: Английский

Small molecule modulators of Alpha-Synuclein Aggregation and Toxicity: Pioneering an Emerging Arsenal Against Parkinson’s Disease DOI
Ishfaq Ahmad Ahanger, Tanveer Ali Dar

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102538 - 102538

Published: Oct. 9, 2024

Language: Английский

Citations

5
The Emerging Roles of Vacuolar-Type ATPase-Dependent Lysosomal Acidification in Cardiovascular Disease DOI Creative Commons
Yanyan Chen, Caixia Liu,

Hai‐Xin Liu

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 525 - 525

Published: April 3, 2025

The vacuolar-type ATPase (V-ATPase) is a multi-subunit enzyme complex that maintains lysosomal acidification, critical process for cellular homeostasis. By controlling the pH within lysosomes, V-ATPase contributes to overall homeostasis, helping maintain balance between degradation and synthesis of components. Dysfunction impairs leading accumulation undigested materials contributing various diseases, including cardiovascular diseases (CVDs) like atherosclerosis myocardial disease. Furthermore, V-ATPase’s role in function suggests potential therapeutic strategies targeting this mitigate disease progression. Understanding mechanisms by which influences pathology essential developing novel treatments aimed at improving outcomes patients with heart vascular diseases.

Language: Английский

Citations

0