Excessive or sustained endoplasmic reticulum stress: one of the culprits of adipocyte dysfunction in obesity DOI Creative Commons

Yu Jiang,

Jiaqi Guo,

Ya Wu

et al.

Therapeutic Advances in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 1, 2024

As the prevalence of obesity continues to rise globally, research on adipocytes has attracted more and attention. In presence nutrient overload, are exposed pressures such as hypoxia, inflammation, mechanical stress, metabolite, oxidative stress that can lead organelle dysfunction. Endoplasmic reticulum (ER) is a vital for sensing cellular pressure, its homeostasis essential maintaining adipocyte function. Under conditions excess nutrition, ER (ERS) will be triggered by gathering abnormally folded proteins in lumen, resulting activation signaling response known unfolded protein responses (UPRs), which system relieve ERS restore homeostasis. However, if UPRs fail rescue homeostasis, activate pathways damage cells. Studies have shown role disturbed pathophysiology complications. Prolonged or excessive aggravate lipolysis, insulin resistance, apoptosis affect bioactive molecule production. addition, also impacts expression some important genes. view fact influences function through various mechanisms, targeting may viable strategy treat obesity. This article summarizes effects during

Language: Английский

Deciphering the Mechanistic Impact of Acupuncture on the Neurovascular Unit in Acute Ischemic Stroke: Insights From Basic Research in a Narrative Review DOI
Hailun Jiang, Chao Zhang,

Mengxuan Lin

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102536 - 102536

Published: Oct. 9, 2024

Language: Английский

Citations

6
Novel Imaging Biomarkers for Brain PET Imaging DOI Creative Commons
Anne M. Landau

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 517 - 517

Published: April 1, 2025

Positron emission tomography (PET) is a critical tool in the study of neurological diseases, providing non-invasive insights into brain's complex molecular and functional processes [...].

Language: Английский

Citations

0
Excessive or sustained endoplasmic reticulum stress: one of the culprits of adipocyte dysfunction in obesity DOI Creative Commons

Yu Jiang,

Jiaqi Guo,

Ya Wu

et al.

Therapeutic Advances in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 1, 2024

As the prevalence of obesity continues to rise globally, research on adipocytes has attracted more and attention. In presence nutrient overload, are exposed pressures such as hypoxia, inflammation, mechanical stress, metabolite, oxidative stress that can lead organelle dysfunction. Endoplasmic reticulum (ER) is a vital for sensing cellular pressure, its homeostasis essential maintaining adipocyte function. Under conditions excess nutrition, ER (ERS) will be triggered by gathering abnormally folded proteins in lumen, resulting activation signaling response known unfolded protein responses (UPRs), which system relieve ERS restore homeostasis. However, if UPRs fail rescue homeostasis, activate pathways damage cells. Studies have shown role disturbed pathophysiology complications. Prolonged or excessive aggravate lipolysis, insulin resistance, apoptosis affect bioactive molecule production. addition, also impacts expression some important genes. view fact influences function through various mechanisms, targeting may viable strategy treat obesity. This article summarizes effects during

Language: Английский

Citations

2