A machine learning approach identifies cellular senescence on transcriptome data of human cells in vitro DOI

Shamsed Mahmud,

Zheng Chen, Fernando E. Santiago

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Language: Английский

A nutrigeroscience approach: Dietary macronutrients and cellular senescence DOI
Mariah F. Calubag, Paul D. Robbins, Dudley W. Lamming

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(9), P. 1914 - 1944

Published: Aug. 23, 2024

Language: Английский

Citations

5
Analysis of cellular senescence-related genes in calcified aortic valve disease and the potential therapeutic role of β-Carotene DOI Creative Commons
Yijing Tao, Chengjie Gao, Juan Wang

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0318574 - e0318574

Published: March 10, 2025

Objective Calcific aortic valve disease (CAVD) is a progressive, age-related degenerative characterized by the accumulation of calcium deposits in valve. We aim to screen key genes associated with cellular senescence (CS) CAVD. Methods The GSE12644 and GSE51472 datasets from GEO database was utilized this study, differentially expressed (DEGs) were identified using “ limma ” R package. CS-related DEGs (CS-DEGs) determined through CellAge database. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses performed on CS-DEGs. A protein–protein interaction (PPI) network constructed STRING cytoHubba plug-in Cytoscape used identify hub genes. noncoding-RNA-mRNA regulatory established. DSigDB drugs potentially be useful for treating Results total 16 CS-DEGs identified. These primarily collagen metabolic process, catabolic process external side plasma membrane. 10 as regulators CAVD: LPAR1, PTPN6, CD28, ID1, MEIS2, FGFR3, KDR, MMP7, AR, HIF1A. Noncoding RNA-mRNA indicated that may regulated noncoding RNAs. β-Carotene, naturally occurring carotenoid antioxidant properties, potential therapeutic agents interacting MMP9, CTSB. Conclusion This study provides insights into pathways related CAVD (MMP9, CTSB) highlights role β-Carotene treatment

Language: Английский

Citations

0
Peptide from tempeh-like fermented Chenopodium formosanum counters senescence while enhancing antioxidant ability in non-replicative aging DOI Creative Commons

Chen‐Che Hsieh,

Hui‐Wen Lin,

Hsiao-Chu Huang

et al.

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117641 - 117641

Published: March 1, 2025

Language: Английский

Citations

0
A machine learning approach identifies cellular senescence on transcriptome data of human cells in vitro DOI

Shamsed Mahmud,

Zheng Chen, Fernando E. Santiago

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Language: Английский

Citations

1