Empagliflozin ameliorates renal and metabolic derangements in obese type 2 diabetic mice by blocking advanced glycation end product–receptor axis
Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
31(1)
Published: March 6, 2025
Language: Английский
Association of Klotho Gene Polymorphisms with Type 2 Diabetes Mellitus
Sahar Mudassar,
No information about this author
Abubakar Sarfraz,
No information about this author
Amina Shahid
No information about this author
et al.
Pakistan Journal of Health Sciences,
Journal Year:
2025,
Volume and Issue:
unknown, P. 295 - 301
Published: Jan. 31, 2025
Genetic
variants
in
the
Klotho
gene
could
influence
way
β-cells
function
and
effectively
glucose
functions,
this
might
development
of
Type
2
Diabetes
Mellitus.
Objectives:
To
investigate
association
between
polymorphisms
rs677332
to
determine
risk
developing
type
II
diabetes
a
case-control
study.
Methods:
This
study
was
conducted
from
Feb
2024
July
at
Department
Pathology,
Rashid
Latif
Medical
College,
Lahore.
The
total
number
participants
n=586,
sample
n=293
case
diabetics
293
controls.
DNA
extracted
blood
samples
genotyped
using
Polymerase
Chain
Reaction
followed
by
restriction
digestion
validated
through
Sanger
sequencing.
evaluate
genetic
clinical
data,
statistical
tests
were
performed
with
SPSS
version
25.0
PLINK
(v1.07).
Logistic
regression
analysis,
adjusted
for
age,
sex,
region,
used
associations
Fasting
levels
as
reference
variable
multiple
nominal
regression.
Results:
SNPs
polymorphism
significantly
correlated,
underscoring
importance
BMI,
heredity
risk.
confirmed
that
individuals
AA
genotype
linked
73%
rise
likelihood
(OR=1.73,
p=0.004).
Conclusions:
may
serve
potential
protective
factor
against
outcomes
report
significance
metabolic
health
indicate
possible
advantages
screening
early
treatment
Language: Английский
Environmental Chemical-Induced Cardiometabolic Disorders: Combined Epidemiological and Experimental Evidence
Environmental Science & Technology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 20, 2025
Screening
environmental
pollutants
that
are
harmful
to
the
cardiometabolic
status
and
understanding
their
key
toxic
pathways
crucial
for
effective
clinical
intervention.
Based
on
exposure
data
of
46
chemicals
in
a
nationally
representative
13,286
people,
logistic
regression
mixture
modeling
were
used
preliminarily
identify
with
significant
impacts
12
indicators
disorders.
A
total
15
found
be
associated
integrated
latent
class,
among
which
four
(perfluorononanoic
acid
[PFNA],
perfluorooctanoic
[PFOA],
thiocyanate,
thallium)
also
contributed
significantly
effect.
We
constructed
adverse
outcome
(AOPs)
nine
toxicants
both
models
individual
each
disorder.
Notably,
fluoroalkyl
substances
affect
multiple
aspects
hyperlipidemia
by
activating
PPARα.
performed
molecular
docking
vitro
experiments
verify
supplement
toxicological
mechanism
PFNA.
Through
binding
PPARα,
PFNA
increased
levels
downstream
molecules
including
CD36
(fatty
transfer),
ACSL1
activation),
CPT1a
(intracellular
transfer
β-oxidation)
ultimately
promoted
accumulation
triglycerides
lipid
droplets
HepG2
cells.
These
markers,
together
events
other
metabolic
phenotypes,
may
potential
targets
scientific
research
or
treatment.
Language: Английский
Exploring the Micro- and Nanoplastics–Diabetes Nexus: Shattered Barriers, Toxic Links, and Methodological Horizons
Environmental Pollution,
Journal Year:
2025,
Volume and Issue:
375, P. 126319 - 126319
Published: April 26, 2025
Language: Английский
Impact of bedroom light exposure on glucose metabolic markers and the role of circadian-dependent meal timing: A population-based cross-sectional study
Qi Li,
No information about this author
Yu-xiang Xu,
No information about this author
Xiaoting Lu
No information about this author
et al.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
290, P. 117589 - 117589
Published: Dec. 26, 2024
Language: Английский