Vasant Kusumakar Rasa Ameliorates Diabetic Encephalopathy by Reducing Oxidative Stress and Neuroinflammation and Improving Neurotransmitter Levels in Experimental Animals DOI Open Access

Alok D Singh,

Mukesh Chawda, Yogesh A. Kulkarni

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Diabetic encephalopathy (DE) is one of the complications diabetes that affects brain. In Ayurveda system medicine, Vasant Kusumakar Rasa (VKR) cited as a classical herbo-mineral formulation for diabetes. However, role VKR in DE still unclear. High-fat diet and streptozotocin (35 mg/kg, i.p.) were used to induce type 2 Sprague Dawley rats. at doses 28 mg/kg 56 was given via intragastric route diabetic rats 16 weeks. Estimation plasma glucose, serum insulin, glycohemoglobin, C-reactive protein (C-RP) analyzed. Furthermore, Morris water maze test performed assess cognitive behavior. Pro-inflammatory, such TNF-α, IL-1β, IL-6, measured brain tissue homogenate. Antioxidant enzyme assays estimate levels malondialdehyde, reduced glutathione, superoxide dismutase, catalase tissue. Histopathology sections using hematoxylin eosin (H & E) staining. Neurotransmitters (viz., serotonin (5-HT), dopamine (DA), norepinephrine (NE)) estimated by high-performance liquid chromatography (HPLC). The data analyzed ANOVA, followed Dunnett's multiple comparison test. treatment, dose glucose level significantly (236.7±17.08 221.8±17.50, respectively; p<0.001) when compared with control (461.7±13.03). treatment also insulin glycated hemoglobin improved escape latency VKR-treated animals animals. Brain pro-inflammatory marker reduced, oxidative stress enzymes showed positive marks treated VKR. demonstrated reduction neuronal damage 5-HT (1.78±0.11 1.72±0.18, respectively) (0.91±0.08) (p<0.01). DA (p<0.01) increased weeks NE result study indicates has significant therapeutic potential management DE.

Language: Английский

Identifying Specificity Protein 2 as a key marker for diabetic encephalopathy in the context of predictive, preventive, and personalized medicine DOI

Guorong Tao,

Xuebao Wang, Jian Wang

et al.

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Language: Английский

Citations

0
Addressing cognitive impairment in hypertensive patients: Risk factors and clinical implications DOI
Yetty Morelent,

Santi Tri Meilina,

Hidayati Azkiya

et al.

Journal of Clinical Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 111105 - 111105

Published: Feb. 1, 2025

Language: Английский

Citations

0
Cognitive Impairment and Synaptic Dysfunction in Cardiovascular Disorders: The New Frontiers of the Heart–Brain Axis DOI Creative Commons
Teresa Soda, Teresa Pasqua, Giovambattista De Sarro

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2387 - 2387

Published: Oct. 18, 2024

Within the central nervous system, synaptic plasticity, fundamental to processes like learning and memory, is largely driven by activity-dependent changes in strength. This plasticity often manifests as long-term potentiation (LTP) depression (LTD), which are bidirectional modulations of efficacy. Strong epidemiological experimental evidence show that heart-brain axis could be severely compromised both neurological cardiovascular disorders. Particularly, disorders, such heart failure, hypertension, obesity, diabetes insulin resistance, arrhythmias, may lead cognitive impairment, a condition known cardiogenic dementia. Herein, we review available knowledge on molecular mechanisms dementia arise describe how LTP and/or LTD induction maintenance CA1 region hippocampus metabolic syndrome, arrhythmias. We also discuss emerging endothelial dysfunction contribute directly altering hippocampal impairing synaptically induced activation nitric oxide synthase. A better understanding CV disorders impact proper function synapses will shed novel light underpinnings dementia, thereby providing new perspective for more specific pharmacological treatments.

Language: Английский

Citations

3
High glucose potentiates Zika virus induced-astroglial dysfunctions DOI
Natalie K. Thomaz, Larissa Daniele Bobermin, Patrícia Sesterheim

et al.

Journal of NeuroVirology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Language: Английский

Citations

1
Mass Spectrometry Imaging Reveals Spatial Metabolic Alterations and Salidroside’s Effects in Diabetic Encephalopathy DOI Creative Commons
Shuohan Cheng,

Xianyue Meng,

Zixuan Wang

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 670 - 670

Published: Dec. 2, 2024

Background: Diabetic encephalopathy (DE) is a neurological complication of diabetes marked by cognitive decline and complex metabolic disturbances. Salidroside (SAL), natural compound with antioxidant neuroprotective properties, has shown promise in alleviating diabetic complications. Exploring the spatial reprogramming DE elucidating SAL’s effects are critical for deepening our understanding its pathogenesis developing effective therapeutic strategies. Methods: Air-flow-assisted desorption electrospray ionization–mass spectrometry imaging (AFADESI-MSI) was employed to investigate alterations brains db/db mice, spontaneous model. The mice were treated SAL (30 150 mg/kg, orally) 12 weeks. Differential metabolites identified characterized using high-resolution mass validated against public databases. Results: Our AFADESI-MSI analysis revealed significant changes 26 compared controls. These indicated disruptions glucose, glutamate-glutamine, nucleotide, lipid, choline, aspartate, L-carnitine metabolism. Notably, glucose 6-phosphate (G6P), glutamine, adenosine, L-carnitine, choline exhibited similar trends both STZ-induced rat models DE, suggesting their potential as reliable biomarkers. Twelve weeks treatment demonstrated positive regulatory effect on metabolism, glutamate–glutamine cycle, lipid Conclusions: This study identifies key demonstrates modulating these disturbances, offering valuable insights targeted interventions

Language: Английский

Citations

0
Vasant Kusumakar Rasa Ameliorates Diabetic Encephalopathy by Reducing Oxidative Stress and Neuroinflammation and Improving Neurotransmitter Levels in Experimental Animals DOI Open Access

Alok D Singh,

Mukesh Chawda, Yogesh A. Kulkarni

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Diabetic encephalopathy (DE) is one of the complications diabetes that affects brain. In Ayurveda system medicine, Vasant Kusumakar Rasa (VKR) cited as a classical herbo-mineral formulation for diabetes. However, role VKR in DE still unclear. High-fat diet and streptozotocin (35 mg/kg, i.p.) were used to induce type 2 Sprague Dawley rats. at doses 28 mg/kg 56 was given via intragastric route diabetic rats 16 weeks. Estimation plasma glucose, serum insulin, glycohemoglobin, C-reactive protein (C-RP) analyzed. Furthermore, Morris water maze test performed assess cognitive behavior. Pro-inflammatory, such TNF-α, IL-1β, IL-6, measured brain tissue homogenate. Antioxidant enzyme assays estimate levels malondialdehyde, reduced glutathione, superoxide dismutase, catalase tissue. Histopathology sections using hematoxylin eosin (H & E) staining. Neurotransmitters (viz., serotonin (5-HT), dopamine (DA), norepinephrine (NE)) estimated by high-performance liquid chromatography (HPLC). The data analyzed ANOVA, followed Dunnett's multiple comparison test. treatment, dose glucose level significantly (236.7±17.08 221.8±17.50, respectively; p<0.001) when compared with control (461.7±13.03). treatment also insulin glycated hemoglobin improved escape latency VKR-treated animals animals. Brain pro-inflammatory marker reduced, oxidative stress enzymes showed positive marks treated VKR. demonstrated reduction neuronal damage 5-HT (1.78±0.11 1.72±0.18, respectively) (0.91±0.08) (p<0.01). DA (p<0.01) increased weeks NE result study indicates has significant therapeutic potential management DE.

Language: Английский

Citations

0