Proteomic and ubiquitinome analysis reveal that microgravity affects glucose metabolism of mouse hearts by remodeling non-degradative ubiquitination DOI Creative Commons
Xin Zhang, Xuemei Zhou, Zhiwei Tu

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(11), P. e0313519 - e0313519

Published: Nov. 14, 2024

Long-term exposure to a microgravity environment leads structural and functional changes in hearts of astronauts. Although several studies have reported mechanisms cardiac damage under conditions, comprehensive research on at the protein level these is still lacking. In this study, proteomic analysis microgravity-exposed identified 156 differentially expressed proteins, ubiquitinomic 169 proteins with differential ubiquitination modifications. Integrated revealed that caused by transcription affect immune response hearts. Additionally, modifications conditions excessively activated certain kinases, such as hexokinase phosphofructokinase, leading metabolic disorders. These findings provide new insights into conditions.

Language: Английский

Histone deacetylase in inflammatory bowel disease: novel insights DOI Creative Commons
Chunxiao Li,

Shaobo Gu,

Yihong Zhang

et al.

Therapeutic Advances in Gastroenterology, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 1, 2025

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is characterized by chronic nonspecific intestinal inflammation. Despite considerable efforts, IBD remains a heavy burden on society human health, with increasing morbidity. Posttranslational modification, especially histone acetylation, key process in controlling DNA transcriptional activity. Histone deacetylases (HDACs) play vital role the mechanism of pathogenesis through nonhistone protein deacetylation. Herein, we present summary different categories HDACs as well HDAC inhibitors (HDACis) analyze inhibition alleviating along its mechanism, clinical potential HDACis treatment.

Language: Английский

Citations

0
UBC9 ameliorates diabetic cardiomyopathy by modulating cardiomyocyte mitophagy through NEDD4/RUNX2/PSEN2 axis DOI

Hanlin Wu,

Zheming Yang, Ting Zhou

et al.

Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156264 - 156264

Published: April 1, 2025

Language: Английский

Citations

0
Proteomic and ubiquitinome analysis reveal that microgravity affects glucose metabolism of mouse hearts by remodeling non-degradative ubiquitination DOI Creative Commons
Xin Zhang, Xuemei Zhou, Zhiwei Tu

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(11), P. e0313519 - e0313519

Published: Nov. 14, 2024

Long-term exposure to a microgravity environment leads structural and functional changes in hearts of astronauts. Although several studies have reported mechanisms cardiac damage under conditions, comprehensive research on at the protein level these is still lacking. In this study, proteomic analysis microgravity-exposed identified 156 differentially expressed proteins, ubiquitinomic 169 proteins with differential ubiquitination modifications. Integrated revealed that caused by transcription affect immune response hearts. Additionally, modifications conditions excessively activated certain kinases, such as hexokinase phosphofructokinase, leading metabolic disorders. These findings provide new insights into conditions.

Language: Английский

Citations

0