Inflammatory mediators-induced DNA damage in liver and brain injury: Therapeutic approach of 5-Methoy-N-acetyltryptamine DOI Creative Commons
Mai O. Kadry, Hanaa M. Ali

Toxicology Reports, Journal Year: 2024, Volume and Issue: 13, P. 101816 - 101816

Published: Nov. 15, 2024

The pathophysiology of hepatic and cerebral damage includes various molecular signalling pathways. Assessment inflammation-induced DNA is one the principal issues for investigating organ distortion mutation. current study was premeditated to discover prophylactic role 5-Methoy-N-acetyltryptamine (5-MNAT) and/or Quercetin (QR) versus sodium nitrite (NaNO

Language: Английский

Deciphering the Mechanistic Impact of Acupuncture on the Neurovascular Unit in Acute Ischemic Stroke: Insights From Basic Research in a Narrative Review DOI
Hailun Jiang, Chao Zhang,

Mengxuan Lin

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102536 - 102536

Published: Oct. 9, 2024

Language: Английский

Citations

6
Mitochondrial Transplantation in Brain Disorders: Achievements, Methods, and Challenges DOI Creative Commons

Aurélien Riou,

Aline Broeglin,

Amandine Grimm

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 105971 - 105971

Published: Dec. 1, 2024

Mitochondrial transplantation is a new treatment strategy aimed at repairing cellular damage by introducing healthy mitochondria into injured cells. The approach shows promise in protecting brain function various neurological disorders such as traumatic injury/ischemia, neurodegenerative diseases, cognitive disorders, and cancer. These conditions are often characterized mitochondrial dysfunction, leading to impaired energy production neuronal death. review highlights promising preclinical studies where has been shown restore function, reduce inflammation, improve motor functions several animal models. It also addresses significant challenges that must be overcome before this therapy can clinically applied. Current efforts these challenges, including advancements isolation techniques, cryopreservation methods, finding an appropriate source, potential delivery routes, discussed. Considering the rising incidence of limited effectiveness current treatments, offers comprehensive overview state research critically assesses remaining obstacles. provides valuable insights could steer future potentially lead more effective treatments for disorders.

Language: Английский

Citations

2
Inflammatory mediators-induced DNA damage in liver and brain injury: Therapeutic approach of 5-Methoy-N-acetyltryptamine DOI Creative Commons
Mai O. Kadry, Hanaa M. Ali

Toxicology Reports, Journal Year: 2024, Volume and Issue: 13, P. 101816 - 101816

Published: Nov. 15, 2024

The pathophysiology of hepatic and cerebral damage includes various molecular signalling pathways. Assessment inflammation-induced DNA is one the principal issues for investigating organ distortion mutation. current study was premeditated to discover prophylactic role 5-Methoy-N-acetyltryptamine (5-MNAT) and/or Quercetin (QR) versus sodium nitrite (NaNO

Language: Английский

Citations

1