Cyclodextrin‐Derived Macromolecular Therapies for Inflammatory Diseases DOI

Yige Tang,

Tao Guo,

X.D. Wang

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Inflammation is an essential physiological defense mechanism against harmful stimuli, yet dysregulated inflammatory responses are closely associated with the pathogenesis of numerous acute and chronic diseases. Recent advances highlight remarkable anti‐inflammatory potential bioactive macromolecules, particularly cyclodextrins (CDs) their engineered derivatives, which emerging as promising therapeutic agents. This review systematically introduces different CDs CD‐derived macromolecules that demonstrate properties, emphasis on molecular mechanisms action. Native exhibit direct effects through host‐guest interactions, enabling selective sequestration pathogenic components such cholesterol crystals proteins drive cascades. Moreover, chemically modified CD derivatives incorporating functional groups enhanced capabilities in neutralizing mediators modulating immune cell responses. work further discusses expanding applications these across diverse conditions, ranging from tissue injuries to autoimmune disorders. Finally, this critically analyzes crucial challenges opportunities translating CD‐based macromolecular therapies into clinical practice, addressing key considerations biocompatibility, targeted delivery, efficacy optimization.

Language: Английский

Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges. DOI Creative Commons
Great Iruoghene Edo, Alice Njolke Mafe, Patrick Othuke Akpoghelie

et al.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

Citations

2
Exploring the Role of GLP-1 Receptor Agonists in Alzheimer’s Disease: A Review of Preclinical and Clinical Evidence DOI Creative Commons
Lívia Cristina Ribeiro Teixeira, Marcelo R. Luizon, Karina Braga Gomes

et al.

Receptors, Journal Year: 2025, Volume and Issue: 4(1), P. 2 - 2

Published: Jan. 26, 2025

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), including dulaglutide, liraglutide, semaglutide, and exenatide, are effective treatments for type 2 diabetes mellitus (T2DM) obesity. These agents mimic the action of endogenous incretin glucagon-like (GLP-1) by enhancing insulin secretion, inhibiting glucagon release, promoting weight loss through appetite suppression. GLP-1RAs have recently been suggested to neuroprotective effects, suggesting their potential as treatment neurodegenerative disorders, such Alzheimer’s disease (AD). AD T2DM share several common pathophysiological mechanisms, resistance, chronic inflammation, oxidative stress, mitochondrial dysfunction. shared mechanisms suggest that therapeutic targeting metabolic dysfunction may also be beneficial conditions. Preclinical studies on in models, both vitro vivo, demonstrated promising reductions amyloid-beta accumulation, decreased tau hyperphosphorylation, improved synaptic plasticity, enhanced neuronal survival. Despite encouraging results from preclinical challenges need addressed before can widely used treatment. Ongoing clinical trials investigating cognitive benefits patients, aiming establish role a option AD. This review aimed examine current literature GLP-1

Language: Английский

Citations

1
Network Diffusion-Constrained Variational Generative Models for Investigating the Molecular Dynamics of Brain Connectomes Under Neurodegeneration DOI Open Access
Jiajia Xie, Raghav Tandon, Cassie S. Mitchell

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1062 - 1062

Published: Jan. 26, 2025

Alzheimer’s disease (AD) is a complex and progressive neurodegenerative condition with significant societal impact. Understanding the temporal dynamics of its pathology essential for advancing therapeutic interventions. Empirical anatomical evidence indicates that network decoupling occurs as result gray matter atrophy. However, scarcity longitudinal clinical data presents challenges computer-based simulations. To address this, first-principles-based, physics-constrained Bayesian framework proposed to model time-dependent connectome during neurodegeneration. This diffusion segments pathological progression into discrete time windows optimizes distributions biomarker regression, conceptualized learning problem. The employs variational autoencoder-like architecture computational enhancements stabilize improve training efficiency. Experimental evaluations demonstrate meta-models outperform traditional static models. models were evaluated using both synthetic real-world MRI PET datasets measure amyloid beta, tau, glucose metabolism. successfully distinguishes normative aging from AD pathology. Findings provide novel support “decoupling” hypothesis reveal eigenvalue-based destabilization in AD. Future optimization model, integrated data, expected applications personalized medicine other diseases.

Language: Английский

Citations

0
Surface-enhanced Raman scattering for the detection of biomarkers of neurodegenerative diseases: A review DOI
Chentao Li,

Yinglin Wang,

Yafang Wu

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: 185, P. 118173 - 118173

Published: Feb. 3, 2025

Language: Английский

Citations

0
Clinical Importance of Amyloid Beta Implication in the Detection and Treatment of Alzheimer’s Disease DOI Open Access

Justyna Pokrzyk,

Agnieszka Kulczynska‐Przybik, Ewa M. Guzik-Makaruk

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1935 - 1935

Published: Feb. 24, 2025

The role of amyloid beta peptide (Aβ) in memory regulation has been a subject substantial interest and debate neuroscience, because both physiological clinical issues. Understanding the dual nature Aβ is crucial for developing effective treatments Alzheimer's disease (AD). Moreover, accurate detection quantification methods isoforms have tested diagnostic purposes therapeutic interventions. This review provides insight into current knowledge about vivo vitro by fluid tests brain imaging (PET), which allow preclinical recognition disease. Currently, priority development new therapies given to potential changes progression In light increasing amounts data, this was focused on employment

Language: Английский

Citations

0
Molecular Mechanisms of Dietary Bioactive Peptides in Treating Alzheimer’s Disease and Mild Cognitive Impairment by Network Pharmacology and Molecular Docking Analysis DOI
Ruirui Li, Jing Zi, Y. Hu

et al.

Rejuvenation Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Emerging evidence suggests that bioactive peptides from various foods have therapeutic potentials in improving cognitive function Alzheimer's disease (AD) and mild impairment (MCI). We aimed to explore the characteristics of these their mechanisms on AD/MCI using a network pharmacology approach. compiled dataset cognition-enhancing literatures identified shared targets between Swiss Target Predication, PharmMapper, OMIM, GeneCards, TTD, Drugbank databases. then performed functional enrichment analysis constructed gene–gene interaction identify key hub targets. Additionally, we investigated transcription factors (TFs) microRNAs (miRNAs) regulating genes. Molecular docking dynamic simulations were AutoDock Vina GROMACS. 59 oligopeptides, typically short rich arginine. These predicted interact with 222 potential relevant AD/MCI, pathways mainly involving neuroactive ligand-receptor interactions inflammation. 15 targets, regulated by 144 TFs 95 miRNAs. Notably, containing "Trp-Tyr" sequence demonstrated strong binding affinities many especially matrix metalloproteinase-9. The findings provided valuable insights into molecular through which may act against highlight for future exploration natural foods.

Language: Английский

Citations

0
Vascular and glymphatic dysfunction as drivers of cognitive impairment in Alzheimer's disease: Insights from computational approaches DOI Creative Commons

Gehan Fatima,

Akm Ashiquzzaman,

Sang Seong Kim

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106877 - 106877

Published: March 1, 2025

Language: Английский

Citations

0
Advanced Biomarkers: Beyond Amyloid and Tau: Emerging Non-Traditional Biomarkers for Alzheimer’s Diagnosis and Progression DOI

Meher Rijwana Afrin,

P. Upadhyaya,

A. Hashim

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102736 - 102736

Published: March 1, 2025

Language: Английский

Citations

0
Unraveling the Molecular Mechanisms of Vitamin Deficiency in Alzheimer's Disease Pathophysiology DOI Creative Commons

Vipul Sharma,

Khadga Raj Aran

Aging and Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 100226 - 100226

Published: March 1, 2025

Language: Английский

Citations

0
Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk DOI Creative Commons
Shirin Pourteymour, Rakesh Kumar Majhi, Frode Norheim

et al.

Cell Proliferation, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

ABSTRACT Ageing is often accompanied by cognitive decline and an increased risk of dementia. Exercise a powerful tool for slowing brain ageing enhancing function, as well alleviating depression, improving sleep, promoting overall well‐being. The connection between exercise healthy particularly intriguing, with exercise‐induced pathways playing key roles. This review explores the link health, focusing on how skeletal muscle influences through muscle–brain crosstalk. We examine interaction well‐known myokines, including brain‐derived neurotrophic factor, macrophage colony‐stimulating vascular endothelial growth factor cathepsin B. Neuroinflammation accumulates in leads to decline, impaired motor skills susceptibility neurodegenerative diseases. Finally, we evidence effects neuronal myelination central nervous system, crucial maintaining health throughout lifespan.

Language: Английский

Citations

0