Bridging the gap between theory and treatment: Transition metal complexes as successful candidates in medicine
Sara Abdolmaleki,
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Alireza Aliabadi,
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Samad Khaksar
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et al.
Coordination Chemistry Reviews,
Journal Year:
2025,
Volume and Issue:
531, P. 216477 - 216477
Published: Feb. 8, 2025
Language: Английский
Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment
Zui Tian,
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Xudong Wang,
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Shuai Chen
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et al.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 1509 - 1528
Published: Feb. 1, 2025
Abstract:
Macrophage
immunotherapy
is
an
emerging
therapeutic
approach
designed
for
modulating
the
immune
response
to
alleviate
disease
symptoms.
The
balance
between
pro-inflammatory
and
anti-inflammatory
macrophages
plays
a
pivotal
role
in
progression
of
inflammatory
diseases.
Mitochondria,
often
referred
as
"power
plants"
cell,
are
essential
organelles
responsible
critical
functions
such
energy
metabolism,
material
synthesis,
signal
transduction.
functional
state
mitochondria
closely
linked
macrophage
polarization,
prompting
interest
strategies
that
target
regulate
this
process.
To
end,
biomaterials
with
excellent
targeting
capabilities
effective
properties
have
been
developed
influence
mitochondrial
function
polarization.
However,
comprehensive
summary
biomaterial-driven
modulation
control
phenotypes
still
lacking.
This
review
highlights
polarization
discusses
mediated
by
biomaterials,
including
mitochondria-targeted
biomaterials.
Finally,
prospects
challenges
use
these
explored,
emphasizing
their
potential
be
translated
clinic.
It
anticipated
will
serve
valuable
resource
materials
scientists
clinicians
development
next-generation
Keywords:
macrophages,
Language: Английский
Association between metallic implants and stroke in US adults from NHANES 2015–2023 a cross-sectional study
Kaichun Wu,
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Liang Pang,
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Pingping Su
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et al.
Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
16
Published: Dec. 20, 2024
Metal
implants
play
a
vital
role
in
orthopedic
treatment
and
are
widely
used
fracture
repair,
joint
replacement
spinal
surgery.
Although
these
often
contain
key
elements
such
as
chromium
(Cr),
their
potential
health
effects,
particularly
association
with
stroke
risk,
have
not
been
fully
elucidated.
This
study
aimed
to
evaluate
the
between
metallic
stroke.
Language: Английский