Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110441 - 110441
Published: May 1, 2025
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 1, 2025
Extracellular particles (EPs), including extracellular vesicles (EVs) and non-vesicular (NVEPs), are multimolecular biomaterials released by cells that play a crucial role in intercellular communication. Recently, new subtypes of EPs associated with central nervous system (CNS), such as exophers supermeres have been identified. These provide perspectives for understanding the pathological progression CNS disorders confer potential diagnostic value liquid biopsies neurodegenerative diseases (NDs). Moreover, emerged promising drug delivery vehicles targeted platforms CNS-specific therapies. In this review, we delineate landscape EP their roles pathophysiology diseases. We also review recent advances EP-based diagnosis NDs highlight importance analytical single-particle resolution exploitation biomarkers. Furthermore, summarize application engineered EVs treatment outline underexplored NVEPs novel therapeutic agents.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: April 1, 2025
Intervertebral disc degeneration (IVDD) is a prevalent condition contributing to various spinal disorders, posing significant global health burden. Mitophagy plays crucial role in maintaining mitochondrial quantity and quality closely associated with the onset progression of IVDD. Well-documented region-specific mitophagy mechanisms IVDD are guiding development therapeutic strategies. In nucleus pulposus (NP), impaired mitochondria lead apoptosis, oxidative stress, senescence, extracellular matrix degradation synthesis, excessive autophagy, inflammation, instability, pyroptosis, key regulatory targets including AMPK, PGC-1α, SIRT1, SIRT3, Progerin, p65, Mfn2, FOXO3, NDUFA4L2, SLC39A7, ITGα5/β1, Nrf2, NLRP3 inflammasome. annulus fibrosus (AF), damage induces apoptosis stress mediated by while cartilage endplate (CEP), dysfunction similarly triggers stress. These mechanistic insights highlight strategies such as activating Parkin-dependent Ub-independent pathways for NP, enhancing AF, targeting Parkin-mediated CEP. include use natural ingredients, hormonal modulation, gene editing technologies, targeted compounds, manipulation related proteins. This review summarizes different regions intervertebral highlights approaches using modulators ameliorate It discusses complex underscores its potential target. The objective provide valuable scientific basis mitochondrial-targeted drugs anti-IVDD.
Language: Английский
Citations
0
Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)
Published: May 3, 2025
Platelet-derived extracellular vesicles (pEVs) are nanoscale, membrane-bound released by platelets during activation or apoptosis. They contain various bioactive and non-bioactive molecules play significant roles in numerous physiological pathological processes through intercellular communication, thus attracting growing attention biomedical research. This review comprehensively overviews the biogenesis, clearance, molecular characteristics of pEVs. It also covers current methodologies for their isolation characterization. The therapeutic implications pEVs key clinical settings like tissue regeneration, hemostasis, immune modulation, vascular repair, with a focus on cancer progression, wound healing, hemorrhagic shock management, explored. Their role cellular signal transduction is examined, functional properties compared other platelet-derived products such as platelet-rich plasma. show potential both agents diagnostic biomarkers. involved modulating inflammatory responses, promoting angiogenesis, enhancing repair mechanisms. Future research should concentrate optimizing efficacy, refining biomarker applications, exploring targeted delivery strategies to fully utilize regenerative medicine, oncology, hemostasis management.
Language: Английский
Citations
0
Acta Materia Medica, Journal Year: 2025, Volume and Issue: 4(3)
Published: Jan. 1, 2025
Aging impairs adipose tissue function and contributes to metabolic disorders, such as obesity insulin resistance. Chronic inflammation is mediated by cytokines, including IL-6, IL-1β, TNF-α, a pivotal factor in aging that links mitochondrial dysfunction activation of the NLRP3 inflammasome aged tissue. Moreover, distinct depots exhibit complex molecular cellular functions related deterioration conventional regulation pathways. Unraveling these mechanisms crucial for developing therapeutic strategies enhance health promote longevity. This review elucidates current understanding lipid metabolism, resistance, senescence, dysfunction. improve quality control tissue, transplantation, hold promise addressing Finally, novel approach transplantation proposed using exosome cargo sustain healthy metabolism thermogenesis populations. These findings lay groundwork innovative therapies preventive mitigate impact aging.
Language: Английский
Citations
0
Advanced NanoBiomed Research, Journal Year: 2025, Volume and Issue: unknown
Published: May 20, 2025
Kidney stone ranks as one of the most prevalent disorders in urology department, causing substantial personal suffering and healthcare costs globally. However, prediction, early diagnosis, treatment kidney disease are still limited. Extracellular vesicles (EVs), loaded with nucleic acids, proteins, metabolites, lipids, released by a wide variety cell types have potential biomarkers for disease. Meanwhile, some natural EVs derived from plants animals been evidenced to effects on elimination calcium oxalate crystals. More importantly, recent explorations elucidated multifaceted role therapeutic applications. These engineered can be RNAs, oligonucleotides, peptides, small molecules; this approach has shown great promise targeted drug delivery presents solution challenges prevention treatment. This review focuses blood, urine, kidney, gut microbiota, urine bacteria, which contribute crystal elimination. The is significant, offering personalized options. it crucial assess moving EV‐based therapies laboratory settings clinical
Language: Английский
Citations
0
Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110441 - 110441
Published: May 1, 2025
Language: Английский
Citations
0