Carbon microelectrodes for the measurement of neurotransmitters with fast-scan cyclic voltammetry: methodology and applications
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 7, 2025
Carbon
microelectrodes
(CMEs)
have
emerged
as
pivotal
tools
in
the
field
of
neurochemical
sensing,
enabling
precise,
real-time
monitoring
neurotransmitters
both
research
and
clinical
contexts.
The
current
review
explores
design,
fabrication,
application
CMEs,
emphasizing
recent
advancements
material
science
electrochemical
techniques
that
enhance
their
sensitivity,
selectivity,
biocompatibility.
Innovations
such
incorporation
nanomaterials,
including
graphene
carbon
nanotubes,
adoption
advanced
fabrication
methods
like
three-dimensional
(3D)
printing
chemical
vapor
deposition,
are
discussed
detail.
These
developments
led
to
significant
improvements
electrode
performance,
reduction
biofouling
interferants,
while
detection
low
concentrations
neurochemicals
complex
biological
systems.
This
further
highlights
potential
CMEs
address
challenges
diagnosing
neurological
disorders
Parkinson's
Disease
depression.
By
integrating
surface
modifications,
polymer
coatings,
method
development
strategies,
demonstrate
high
durability,
reduced
fouling,
enhanced
specificity.
Despite
these
advancements,
remain
related
long-term
vivo
stability,
batch
reproducibility,
thus
necessitating
optimization.
transformative
therapeutic
applications,
providing
a
comprehensive
overview
state
future
directions.
addressing
existing
limitations
leveraging
emerging
technologies,
sensing
contribute
breakthroughs
neuroscience
biomedical
science.
Language: Английский
The Role of Genetic, Environmental, and Dietary Factors in Alzheimer’s Disease: A Narrative Review
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1222 - 1222
Published: Jan. 30, 2025
Alzheimer’s
disease
(AD)
is
one
of
the
most
common
and
severe
forms
dementia
neurodegenerative
disease.
As
life
expectancy
increases
in
line
with
developments
medicine,
elderly
population
projected
to
increase
next
few
decades;
therefore,
an
prevalence
some
diseases,
such
as
AD,
also
expected.
a
result,
until
radical
treatment
becomes
available,
AD
expected
be
more
frequently
recorded
top
causes
death
worldwide.
Given
current
lack
cure
for
only
treatments
available
being
ones
that
alleviate
major
symptoms,
identification
contributing
factors
influence
incidence
crucial.
In
this
context,
genetic
and/or
epigenetic
factors,
mainly
environmental,
disease-related,
dietary,
or
combinations/interactions
these
are
assessed.
review,
we
conducted
literature
search
focusing
on
environmental
air
pollution,
toxic
elements,
pesticides,
infectious
agents,
well
dietary
including
various
diets,
vitamin
D
deficiency,
social
(e.g.,
tobacco
alcohol
use),
variables
affected
by
both
behavior
gut
microbiota.
We
evaluated
studies
beneficial
effects
antibiotics
Mediterranean-DASH
Intervention
Neurodegenerative
Delay
(MIND)
Mediterranean
diets.
Language: Английский
Role of OX/OXR cascade in insomnia and sleep deprivation link Alzheimer’s disease and Parkinson’s disease: Therapeutic avenue of Dual OXR Antagonist (DORA)
Biochemical Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 116794 - 116794
Published: Feb. 1, 2025
Language: Английский
A comprehensive review of neurotransmitter modulation via artificial intelligence: A new frontier in personalized neurobiochemistry
Jaleh Bagheri Hamzyan Olia,
No information about this author
Arasu Raman,
No information about this author
Chou‐Yi Hsu
No information about this author
et al.
Computers in Biology and Medicine,
Journal Year:
2025,
Volume and Issue:
189, P. 109984 - 109984
Published: March 14, 2025
Language: Английский
Disruption in the human microbiome causing behavioural changes in bipolar disorder
International review of neurobiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Language: Английский
Decoding serotonin: the molecular symphony behind depression
Yue Shu,
No information about this author
Lei Tian,
No information about this author
Xing Wang
No information about this author
et al.
Frontiers in Cellular Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: April 24, 2025
The
serotonin
(5-hydroxytryptamine)
system
represents
a
crucial
neurotransmitter
network
that
regulates
mood,
behavior,
and
cognitive
functions,
playing
significant
role
in
the
pathogenesis
progression
of
depression.
Although
this
perspective
faces
challenges,
continues
to
exert
substantial
modulatory
effects
on
specific
aspects
psychological
functioning
actively
contributes
multiple
pathological
processes
depression
development.
Therefore,
review
systematically
integrates
interdisciplinary
research
advances
regarding
relationship
between
5-hydroxytryptamine
(5-HT)
By
focusing
core
biological
including
biosynthesis
metabolism,
SERT
gene
regulatory
networks,
protein
molecular
modifications,
it
aims
elucidate
how
5-HT
dysregulation
development
depression,
while
providing
novel
perspectives
therapeutic
targets
for
innovative
antidepressant
drug
Language: Английский