Tauopathy after long‐term cervical lymphadenectomy DOI Creative Commons
Chenrui Wu, Jiangyuan Yuan, Yu Tian

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(4)

Published: April 1, 2025

Abstract INTRODUCTION This study examined the effects of long‐term cervical lymphadenectomy (cLE) on cognitive and Alzheimer's disease (AD)–like tauopathy changes. METHODS Male C57BL/6 mice were used to assess cLE impacts sleep, brain pathways, pathologies. RNA sequencing proteomics analyzed gene/protein changes, with results verified by western blotting immunofluorescence. RESULTS CLE led sleep psychiatric disorders, linked mitogen‐activated protein kinase/extracellular signal‐regulated kinase (ERK) pathway activation. Activation ERK may interfere autophagy is associated phosphorylated tau accumulation. Peripheral blood analysis shows decreased waste in peripheral post‐cLE, implicating impaired lymphatic drainage build‐up. DISCUSSION These findings suggest a potential connection between AD‐like tauopathy, potentially influencing surgical decisions. Highlights Cervical cornerstone head neck cancers, affecting millions people each year. We provide first evidence mildly functioning significant anxiety–depressive disorders after cLE. Long‐term not only directly impairs wastes (amyloid beta, [p‐tau]) drainage, but also activates Erk1/2 signaling leading attenuation autophagy. found for time that accelerated deposition p‐tau young mice. Patients clinical lymph node dissection showed reduced consistent mouse models. suggests need further evaluation neurologic dissection, procedure affects

Language: Английский

Mitophagy in Neurodegenerative Diseases: Mechanisms of Action and the Advances of Drug Discovery DOI
Panpan Yang,

Shuai Wen,

Xin Wang

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Neurodegenerative diseases (NDDs), such as Parkinson's disease (PD) and Alzheimer's (AD), are devastating brain incurable at the moment. Increasing evidence indicates that NDDs associated with mitochondrial dysfunction. Mitophagy removes defective or redundant mitochondria to maintain cell homeostasis, whereas deficient mitophagy accelerates accumulation of damaged mediate pathologies NDDs. Therefore, targeting has become a valuable therapeutic pathway for treatment Several modulators have been shown ameliorate neurodegeneration in PD AD. However, it remains be further investigated other Here, we describe mechanism key signaling summarize roles on pathogenesis Further, underline development advances AD therapy, discuss challenges limitations existing modulators, provide guidelines exploration drug design.

Language: Английский

Citations

0
Gallic acid alleviates Alzheimer's disease by inhibiting p38/MAPK signaling pathway DOI
Jiaxin Wang, Qingling Wang,

Xiao Tu

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 127, P. 106745 - 106745

Published: March 21, 2025

Language: Английский

Citations

0
Tauopathy after long‐term cervical lymphadenectomy DOI Creative Commons
Chenrui Wu, Jiangyuan Yuan, Yu Tian

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(4)

Published: April 1, 2025

Abstract INTRODUCTION This study examined the effects of long‐term cervical lymphadenectomy (cLE) on cognitive and Alzheimer's disease (AD)–like tauopathy changes. METHODS Male C57BL/6 mice were used to assess cLE impacts sleep, brain pathways, pathologies. RNA sequencing proteomics analyzed gene/protein changes, with results verified by western blotting immunofluorescence. RESULTS CLE led sleep psychiatric disorders, linked mitogen‐activated protein kinase/extracellular signal‐regulated kinase (ERK) pathway activation. Activation ERK may interfere autophagy is associated phosphorylated tau accumulation. Peripheral blood analysis shows decreased waste in peripheral post‐cLE, implicating impaired lymphatic drainage build‐up. DISCUSSION These findings suggest a potential connection between AD‐like tauopathy, potentially influencing surgical decisions. Highlights Cervical cornerstone head neck cancers, affecting millions people each year. We provide first evidence mildly functioning significant anxiety–depressive disorders after cLE. Long‐term not only directly impairs wastes (amyloid beta, [p‐tau]) drainage, but also activates Erk1/2 signaling leading attenuation autophagy. found for time that accelerated deposition p‐tau young mice. Patients clinical lymph node dissection showed reduced consistent mouse models. suggests need further evaluation neurologic dissection, procedure affects

Language: Английский

Citations

0