The Complex Relationship Between Gut Microbiota and Alzheimer’s Disease: A Systematic Review DOI Creative Commons

Xuan-Peng Zhou,

Lei Sun, Wenhao Liu

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102637 - 102637

Published: Dec. 1, 2024

Alzheimer's disease (AD) is a progressive, degenerative disorder of the central nervous system. Despite extensive research conducted on this disorder, its precise pathogenesis remains unclear. In recent years, microbiota-gut-brain axis has attracted considerable attention within field AD. The gut microbiota communicates bidirectionally with system through gut-brain axis, and alterations in structure function can influence progression Consequently, regulating to mitigate AD emerged as novel therapeutic approach. Currently, numerous studies concentrate intrinsic relationship between paper, we summarize multifaceted role present detailed strategies targeting microbiota, including treatment Traditional Chinese Medicine (TCM), which garnered increasing years. Finally, discuss potential for modulating alleviate AD, current challenges area research, provide an outlook future directions field.

Language: Английский

Gut microbiota and atrial cardiomyopathy DOI Creative Commons

Tingting Sun,

Beibei Song, Bo Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 4, 2025

Atrial cardiomyopathy is a multifaceted heart disease characterized by structural and functional abnormalities of the atria closely associated with atrial fibrillation its complications. Its etiology involves number factors, including genetic, infectious, immunologic, metabolic factors. Recent research has highlighted critical role gut microbiota in pathogenesis cardiomyopathy, this consistent gut–heart axis having major implications for cardiac health. The aim work to bridge knowledge gap regarding interactions between particular focus on elucidating mechanisms which dysbiosis may induce remodeling dysfunction. This article provides an overview changes composition effects metabolites. We also discuss how diet exercise affect influencing microbiota, as well possible future therapeutic approaches targeting axis. A healthy can prevent disease, but ecological lead variety symptoms, induction disease. pathophysiological aspects impact structure function, strategies exploring modulation treatment cardiomyopathy. Finally, we fecal transplantation oral probiotics or prebiotics. Our study highlights importance homeostasis cardiovascular health suggests that targeted interventions pave way innovative preventive

Language: Английский

Citations

0
Senile Osteoarthritis Regulated by the Gut Microbiota: From Mechanisms to Treatments DOI Open Access

Yu Fan,

Chenyu Zhu,

Wei Wu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1505 - 1505

Published: Feb. 11, 2025

Osteoarthritis (OA) is a chronic, progressive degenerative joint disease that affects the entire synovial joint, leading to degeneration of articular cartilage. It seriously quality life and global disability patients. OA affected by variety factors; most significant risk factor for age. As individuals age, severity increase due exacerbation cartilage wear tear. In recent years, research has indicated gut microbiota may play role in aging processes. anticipated regulating offer novel approaches treatment OA. The objective this paper examine relationship between senile OA, investigate potential mechanisms involved. This review also summarizes therapeutic strategies related flora management, such as prebiotics probiotics, diet, exercise, traditional Chinese medicine (TCM) modification, fecal transplantation (FMT), highlighting clinical value elucidating current challenges. foundation future directions established through summarization progress.

Language: Английский

Citations

0
AGING THROUGH THE LENS OF THE GUT MICROBIOME: CHALLENGES AND THERAPEUTIC OPPORTUNITIES DOI Creative Commons

N.V. Kanimozhi,

M. Sukumar

Archives of Gerontology and Geriatrics Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100142 - 100142

Published: March 1, 2025

Language: Английский

Citations

0
The Complex Relationship Between Gut Microbiota and Alzheimer’s Disease: A Systematic Review DOI Creative Commons

Xuan-Peng Zhou,

Lei Sun, Wenhao Liu

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102637 - 102637

Published: Dec. 1, 2024

Alzheimer's disease (AD) is a progressive, degenerative disorder of the central nervous system. Despite extensive research conducted on this disorder, its precise pathogenesis remains unclear. In recent years, microbiota-gut-brain axis has attracted considerable attention within field AD. The gut microbiota communicates bidirectionally with system through gut-brain axis, and alterations in structure function can influence progression Consequently, regulating to mitigate AD emerged as novel therapeutic approach. Currently, numerous studies concentrate intrinsic relationship between paper, we summarize multifaceted role present detailed strategies targeting microbiota, including treatment Traditional Chinese Medicine (TCM), which garnered increasing years. Finally, discuss potential for modulating alleviate AD, current challenges area research, provide an outlook future directions field.

Language: Английский

Citations

1